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Biomedical subjects

R Sandyk

Publications and source records attributed to R Sandyk.

At least 307 records · Page 17Linked to original sources
PubMed1987

L-dopa in uremic patients with the restless legs syndrome.

Restless legs syndrome (RLS) is a poorly understood, often distressing condition that is particularly prevalent among patients with chronic renal failure. A wide variety of medications have been used to treat RLS with variable results. In order to evaluate the efficacy of carbidopa/levodopa therapy, eight consecutive uremic patients with RLS on maintenance hemodialysis were treated with doses ranging from 25/100 to 25/250 twice daily. Six of eight patients obtained satisfactory relief which has continued for 3 months follow-up. Carbidopa-levodopa appears to be an effective opinion in management of RLS in patients with chronic rental failure.

Aged↗
PubMed1987

Cerebral cysticercosis presenting as progressive dementia.

Cysticercosis is a parasitic infestation that commonly affects the central nervous system. This is a report of an elderly man who presented with progressive dementia, labelled as Alzheimer's in whom diffuse cerebral cysticercosis was subsequently demonstrated. The dementia responded favorably to treatment with steroids and mebendazole. This report demonstrates the importance of excluding cerebral cysticercosis as a treatable cause of progressive dementia.

Aged↗
PubMed1987

Baclofen responsive posttraumatic epilepsy.

A 21-year-old man with posttraumatic epilepsy was poorly controlled on conventional anticonvulsant agents (phenytoin, carbamazepine). However, co-administration of the GABA mimetic agent baclofen improved significantly his seizure control, suggesting that the latter agent could be useful in the management of refractory epilepsy.

Adult↗
PubMed1987

Acute psychosis in a woman with a prolactinoma.

Changes in dopaminergic activity were inferred in a woman with a known prolactinoma several months prior to an acute psychotic episode. Serum prolactin levels reflected central dopaminergic activity, since both the endocrinologic regulation of prolactinomas and the pathophysiology of acute psychosis have been linked to alterations in dopaminergic activity. Serum prolactin levels fell approximately four months prior to onset of the psychotic episode and thus may have provided a predictive indicator of changing dopamine activity in both the tubero-infundibular and the mesolimbic-mesocortical dopaminergic systems.

Adult↗
PubMed1987

Baclofen in hemifacial spasm.

Six patients with idiopathic hemifacial spasm refractory to the usually employed medications were successfully treated with baclofen. Adverse side effects were found in only 1 patient (memory loss) which was controlled with administration of piracetam. We suggest that there is an association between stress and certain cases of hemifacial spasm and that such stress related cases may respond positively to baclofen.

Adult↗
PubMed1987

Sleep disorders in Tourette's syndrome.

Sleep disorders have been reported in approximately 80% of Tourette's syndrome (TS) patients. Sleep studies in TS patients have demonstrated a 30% reduction in delta-sleep (slow-wave sleep) in nontreated subjects, decreased percentage of REM-sleep and the presence of tics during sleep. A subgroup of young TS patients was reported to have an increased percentage of delta sleep. Although these findings were initially thought to result from deranged dopaminergic and serotoninergic functions in TS, we suggest that abnormalities of hypothalamic-mediated control mechanisms involving the intrinsic opioids may also account for the observed derangements in sleep-wave patterns in TS patients. Evidence for impaired hypothalamic regulation in TS patients includes our preliminary observations of abnormal growth-hormone release to administration of the opiate antagonist naloxone in TS. These data further suggest an interrelationship of neurochemical mechanisms involving opioid-mediated hyperactivity, slow-wave sleep and growth hormone at the level of the hypothalamus.

Biomechanical Phenomena↗
PubMed1987

Amantadine for levodopa resistant parkinsonism.

A 65-year-old woman with stigmata of Parkinsonism was resistant to therapy with levodopa, bromocriptine and anticholinergics. However, administration of amantadine (Symmetrel), (200 mg/day) produced significant improvement in her motor disability as well as in her mental status. The mechanisms of amantadine's therapeutic effects in this unusual case are discussed.

Aged↗
PubMed1987

Spinal dopamine mechanisms and primary sensory symptoms in Parkinson's disease.

Primary sensory symptoms occur in approximately 40% of patients with Parkinson's disease. Although the pathophysiology of these symptoms is poorly understood, the recent discovery of diencephalospinal dopaminergic neuronal pathways potentially implicates this system in the etiology of these symptoms. The possible contribution of the hypothalamus with its connections to descending midbrain structures and the spinal cord to the etiology of primary sensory symptoms in Parkinson's disease are discussed.

Animals↗