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Biomedical subjects

R Sakazaki

Publications and source records attributed to R Sakazaki.

At least 91 records · Page 5Linked to original sources
PubMed1978

Two epidemics of diarrhoeal disease possibly caused by Plesiomonas shigelloides.

Two epidemics of water-borne diarrhoeal disease involving a total of 1000 persons are reported. In both epidemics, none of the usual bacterial entero-pathogens were recognized and Plesiomonas shigelloides was the only suspect aetiological agent isolated. The ecology of P. shigelloides was investigated in these outbreaks. It was recognized as an inhabitant of fresh surface water and its presence was closely related to warm weather.

Bacterial Infections↗
PubMed1978

Prevalence of non-cholera vibrios in cavum nasi and pharynx of ducks.

Investigations among ducks on ten different farms showed a high prevalence of Vibrio cholerae in cavum nasi and Pharynx after the ducks were admitted to the open field. In no case was Vibrio cholerae isolated from ducks which had never been outside the houses. At least six serovars were isolated, 0:54 being the most prevalent. All the strains isolated produced a distinctive cytotoxic effect in YI adrenal cells and caused fluid accumulation in rabbit gut loops. Migratory birds were incriminated as the source of initial contamination.

Age Factors↗
PubMed1978

On the serology of Plesiomonas shigelloides.

The serology of 87 strains of Plesiomonas shigelloides was studied. Thirty O antigenic groups and 11 H antigens were defined within the 87 strains, and an antigenic schema consisting of 40 serovars was established. Some O antigens of P. shigelloides were identical or closely related to those of some Shigella serovars.

Agglutination Tests↗
PubMed1976

The total structure of cerexin A (studies on antibiotics from the genus Bacillus. XVI.

The constituent fatty acid of cerexin A was elucidated to be beta-hydroxy isoundecanoic acid by gas chromatography, mass spectrometry and nuclear magnetic resonance. The asparaginyl asparagine linkage in the amino acid sequence of the antibiotic, which has been previously described, was proved to be a normal alpha-carboxylpeptide bond by dehydration-reduction procedure. The three asparagine residues in the sequence were isolated separately and their chiralities were determined. The structure of cerexin A was concluded from the above results.

Amino Acid Sequence↗
PubMed1976

Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX.

A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.

Animals↗
PubMed1976

Isolation of a new antibiotic, laterosporamine. Studies on antibiotics from the genus Bacillus. XIII.

A new antibiotic, named laterosporamine, was isolated from the culture broth of Bacillus laterosporus 340-19. The antibiotic is active against Gram-positive and Gram-negative bacteria in vitro and in vivo. It is a water-soluble basic substance, positive to ninhydrin, SAKAGUCHI'S and DRAGENDORFF'S reagents. A non-peptidic structure with an approximate empirical formula C17H35N7O4 was suggested.

Animals↗
PubMed1976

The constituent amino acids and fatty acid of antibiotic 333-25. (Studies on antibiotics from the genus Bacillus. XII.

Measurement of the optical rotational activities of the constituent amino acids of antibiotic 333-25 identified 2,4-diaminobutyric acid (D-form 1, L-form 4), L-leucine (2) and D-phenylalanine (1). The fatty acid constituent was determined to be beta-hydroxy anteisononanoic acid by gas chromatography, nuclear magnetic resonance and mass spectra. Differentiation from the structure of antibiotic EM 49 is discussed.

Amino Acids↗
PubMed1975

Isolation of galantins I and II, water-soluble basic peptides. Studies on antibiotics from the genus Bacillus. III.

Two water-soluble basic antibiotics named galantins I and II were isolated from a strain resembling Bacillus pulvifaciens. Both antibiotics are peptides containing glycine, alanine, ornithine, lysine and some unknown ninhydrin-positive components. An approximate empirical formula C50 plus and minus H98plus and minus 2O17N16 is indicated for galantin I. These are active against some gram-positive, acid-fast and gram-negative bacteria.

Alanine↗
PubMed1975

Isolation of a new peptide antibiotic complex 61-26. Studies on antibiotics from the geneus Bacillus. V.

A new antibiotic named 61-26 active against gram-positive bacteria and some fungi was isolated from a Bacillus strain. The antibiotic is a weakly basic peptide slightly soluble in aqueous alcohols. An approximate empirical formula of C50H93N11O17 and constituent amino acids of aspartic acid (1 mole), serine(2 moles), alanine (2moles), and sum of valine and isoleucine (2 moles) are indicated.

Alanine↗