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Biomedical subjects

R S Sharma

Publications and source records attributed to R S Sharma.

At least 109 records · Page 6Linked to original sources

Sparganosis.

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Adult↗

Combined effect of hypoxia and cold on the phospholipid composition of lung surfactant in rats.

The phsopholipid composition of lung tissue and lung lavage in rats exposed to acute hypoxia, chronic hypoxia, and acute and chronic hypoxia associated with cold has been estimated and compared with controls. Different fractions of phospholipids were separated by thin layer chromatography. Results showed that acute hypoxia lowered phospholipids in lung lavage but superimposition of cold lowered phospholipids both in lung tissue and lavage. In chronic hypoxia, phospholipid contents of lung tissue and lavage decreased while the addition of cold showed no further reduction in lung tissue phospholipids; on the contrary phosphatidyl choline fraction of lung lavage increased. It is concluded that the effect of hypoxia alone in lowering surfactant is related to the duration of exposure. Cold with hypoxia lowers phospholipids in the acute stage; in the chronic stage; it does not further reduce phospholipids.

Animals↗

Haemoglobin Bart's hydrops fetalis syndrome in an infant of Greek origin and prenatal diagnosis of alpha-thalassaemia.

An unusual case of Bart's hydrops fetalis is reported where the patient was born to parents of Greek origin. An exchange transfusion was given. Adult haemoglobin (HbA) was present in addition to HbBart's and HbPortland. A low level of synthesis of alpha-chains was evident. The mother presented again in a subsequent pregnancy for prenatal diagnosis of thalassaemia. The fetus was diagnosed as an alpha-thalassaemia carrier, a diagnosis which was confirmed at birth. The nature of alpha-thalassaemia in the family is discussed.

Australia↗