Search PubMed⌕ Search

Biomedical subjects

R S Adler

Publications and source records attributed to R S Adler.

At least 19 recordsLinked to original sources
PubMed2003

Ultrasound in the detection and treatment of a painful stump neuroma.

Ultrasound is an established modality for the evaluation of neuromas, particularly Morton's neuromas. It has also had success in the assessment of amputation stump neuromas. While ultrasound localization for steroid injection has proven useful in the conservative treatment of Morton's neuromas, it has not yet been established as a localization technique for steroid injection to successfully treat amputation stump neuromas.

Amputation, Surgical↗
PubMed2001

On the relationship between power mode and pressure amplitude decorrelation.

Estimation of mean transit time, along with tissue blood volume, are important factors in determining soft tissue perfusion. Recently, power mode decorrelation techniques have been successfully used to estimate mean transit time of red blood cells or contrast material through a region-of-interest (ROI) both in laminar flow phantoms and in vivo. The previously described theory for power mode decorrelation derives from a phenomenological stochastic differential equation (Langevin equation) based on conservation of matter, relating the detected signal power to the measured rate of decorrelation. Given the experimental support for power mode decorrelation as a method to estimate mean transit time, it becomes important to determine the relationship between the phenomenological parameters that appear in the corresponding stochastic equation and system parameters, such as the transducer point response function. With this equation as a starting point, and using the fact that the pressure amplitude is a Gaussianly distributed random process, the following stochastic differential equation for the pressure amplitude p(t) is derived, a necessary first step in establishing the relationship between the measured decorrelation rate and system parameters (i.e., point response function): dp(t)/dt = -(v/2+2ik x v)p(t)+f(t), where v/2 represents the rate of decorrelation, 2k x v is the Doppler shift for an insonating wave vector k and particle velocity v.f(t) is a stationary, white noise Gaussian random process.

Blood Pressure↗
PubMed2001

Use of ultrasonographic guidance in interventional musculoskeletal procedures: a review from a single institution.

We have evaluated the utility of ultrasonographic guidance for intervention in the musculoskeletal system. All interventional musculoskeletal procedures using ultrasonographic guidance performed at our institution from July 1998 through November 1999 were reviewed. Examinations were performed using either a linear or curved phased array transducer, based on depth and local geometry. The choice of needle was likewise optimized for specific anatomic conditions. One hundred ninety-five procedures were performed on 167 patients from July 1998 through November 1999. Thirty-one procedures had magnetic resonance correlation within 6 months beforehand. Excluding large-joint aspirations and injections, we found that 180 of the procedures were more readily performed using ultrasonography than any other imaging modality. These included therapeutic injections into tendon sheaths (biceps, flexor digitorum longus, posterior tibial, and iliopsoas), Morton's neuromas, plantar fascia, wrist ganglia, and tarsal tunnel cysts; peritendinous hamstring injections; and synovial cyst and muscle biopsies. In all cases, the target of interest was identified easily with ultrasonography, and needle position was documented readily. Also in all cases, aspiration or medication delivery to the site of interest was observed during real time and was documented on postprocedure images of the area. No significant complications (e.g., bleeding, infection, and neurovascular compromise) were encountered during or immediately after any procedure. Ultrasonography is a readily available imaging modality useful for guiding interventional procedures in the musculoskeletal system. The ability to document exact needle placement in real time confirms accurate placement of therapeutic injections, fluid aspiration, and soft tissue biopsies.

Adolescent↗
PubMed2000

Sonography of the glenoid labrum: a cadaveric study with arthroscopic correlation.

OBJECTIVE: We assessed the usefulness of sonography in evaluating the glenoid labrum in cadaveric specimens using arthroscopy as a standard of reference. MATERIALS AND METHODS: Eighty labral quadrants in 20 cadaveric shoulders were examined by two musculoskeletal radiologists using 5- to 7-MHz linear and curvilinear transducers. Agreement was reached by consensus. After sonography, arthroscopy was performed by an experienced orthopedic surgeon. Each labral quadrant was classified at the time of sonography and arthroscopy as normal, degenerated, or torn. RESULTS: Concordance between sonography and arthroscopy was 86% (69/80 quadrants). In differentiating abnormal labrum (tear or degeneration) from normal labrum using sonography, sensitivity was 63%, specificity was 98%, positive predictive value was 94%, negative predictive value was 86%, and accuracy was 88%. In differentiating labral tears from other labral conditions (degeneration or normality), sensitivity was 67%, specificity was 99%, positive predictive value was 67%, negative predictive value was 99%, and accuracy was 98%. CONCLUSION: Sonography has a promising role in the evaluation of the glenoid labrum, particularly in excluding labral tears when the labra appear normal on sonography. Further studies are required using normal and symptomatic patients to determine the usefulness of sonography in the diagnosis of labral abnormalities.

Aged↗
PubMed2000

Sonography of tears of the distal biceps tendon.

OBJECTIVE. The objective of this study was to describe the sonographic appearance of tears of the distal biceps brachii tendon. CONCLUSION. Sonography can reveal complete and partial tears of the distal biceps tendon, thus providing an alternative technique to MR imaging.

Elbow↗
PubMed2000

Evaluation of bone contusions with fat-saturated fast spin-echo proton-density magnetic resonance imaging.

OBJECTIVE: To evaluate the efficacy of fast spin-echo proton-density magnetic resonance imaging (MRI) with fat saturation sequences in the evaluation of bone contusions at the knee. METHODS: Analysis of 46 consecutive knee MRI examinations performed on patients referred from a sports medicine clinic after knee trauma. All examinations included coronal fast spin-echo proton-density fat saturation, fast spin-echo proton-density and fast spin-echo T2-weighted sequences. All 3 coronal sequences were blindly reviewed independently of each other by 3 experienced musculoskeletal radiologists to identify and grade bone contusions. RESULTS: Thirty-five bone contusions were identified in 24 patients. All bone contusions were identified on fast spin-echo proton-density fat saturation sequences, which was significantly greater than the percentage identified on either fast spin-echo T2-weighted sequences (21/35, 60%, p < 0.001) or fast spin-echo proton-density sequences (10/35, 29%, p < 0.001). Fourteen (40%) of the contusions were identified only on the fast spin-echo proton-density fat saturation sequences. The average grade of contusion for all 35 examinations was also significantly higher on the fast spin-echo proton-density fat saturation sequences than on the fast spin-echo proton-density and fast spin-echo T2-weighted sequences (p < 0.05). CONCLUSION: Fast spin-echo proton-density fat saturation sequences are more sensitive in the detection of bone contusions than fast spin-echo proton-density and fast spin-echo T2-weighted sequences. Assessment of other structures in the knee with fast spin-echo proton-density fat saturation MRI provides good spatial resolution and adequate T2-weighted information. It may have advantages over the more heavily T2-weighted fast spin-echo T2 fat saturation and inversion recovery sequences.

Adult↗
PubMed1999

Future and new developments in musculoskeletal ultrasound.

Improvements in high-resolution gray-scale imaging and clinical expertise performing musculoskeletal ultrasound will undoubtedly continue. Development of digital beam formers, two-dimensional arrays along with exploitation of nonlinear techniques to achieve higher resolution and use of ultrasound contrast to improve flow sensitivity will all contribute to the utility of ultrasound in the musculoskeletal system. It behooves the radiologic community to become familiar with these techniques, not only for economic reasons, but also because of the rich complement of future applications of this modality. The few potential applications mentioned here may only scratch the surface of what is possible. In addition to improved images of tissue morphology, ultrasound may play a role in functional and quantitative assessment of soft tissues. It may likewise play a role in the evaluation of prosthetic implants, bone mineralization, and cartilage integrity. Thus, the role of this modality in future musculoskeletal applications may significantly impact clinical diagnosis and therapy.

Humans↗
PubMed1999

Speckle decorrelation flow measurement with B-mode US of contrast agent flow in a phantom and in rabbit kidney.

PURPOSE: To use speckle decorrelation in the presence of ultrasonographic (US) contrast agent as an alternative flow measurement technique to Doppler US. MATERIALS AND METHODS: In vivo and in vitro studies were performed. A tube with flowing saline solution containing contrast agent was positioned horizontally across a US image. The amount of decorrelation between a series of images was recorded. The flow profile across the tube was generated by averaging the decorrelation values and was compared with a Doppler frequency shift image. In addition, B-mode images of six rabbit kidneys were obtained during and after intravenous injection of contrast agent. Images were analyzed to compute the correlation between successive points in time. RESULTS: The velocity profiles across the tube were parabolic, with the fastest flow rates measured in the center of the tube. In the rabbit kidneys, measurements indicated the largest decorrelation rates occurred in the larger vessels. The cortical decorrelation rates were significantly slower than those for the hilar vessels (P < .05) and were relatively angle independent. CONCLUSIONS: Decorrelation flow measurements can be used to estimate flow in vitro and in vivo similar to measurements obtained with Doppler US but with less angle dependence. These measurements could lead to a US perfusion technique.

Animals↗
PubMed1999

Evaluation of soft-tissue masses using segmented color Doppler velocity images: preliminary observations.

OBJECTIVE: We report our initial experience with segmented color Doppler velocity-based estimates of tumor vascularity for various histogically proven soft-tissue masses. SUBJECTS AND METHODS: Color Doppler sonography of 23 histologically proven masses in 22 patients was performed. Digital color Doppler images were acquired directly off the scanner output or from video recordings and stored on a personal computer as 24-bit gray-scale and color composite images. A color Doppler velocity segmentation and analysis algorithm was applied to the digital images, from which we calculated the normalized percentage of color Doppler area. Normalization was determined by expressing color Doppler area as a percentage of the area enclosed by a preselected region of interest. We also calculated mean percentage, SD, and cumulative distribution of color Doppler area, relative to a fixed threshold, for the acquired image data sets. RESULTS: Estimates of mean percentage of color Doppler area showed a dynamic range of at least two or three orders of magnitude between lowest and highest values obtained. A scatterplot of mean percentage of color Doppler area versus SD of percentage of color Doppler area showed a linear monotonic relationship (r2 = .92), illustrating increasing vascular heterogeneity with mean vascularity. Preliminary data also suggest the presence of at least two distinct groups of masses (p < .0001) based on these vascularity estimates. One group corresponds to high-grade lesions in which tumor angiogenesis is expected to be important in predicting biologic behavior. The second group appeared to have little or no relationship to tumor vascularity or was of an intermediate (or lower) histologic grade. CONCLUSION: Quantitative color Doppler estimates of tumor vascularity can be obtained over a wide dynamic range. Such estimates provide a mechanism to assess vascular heterogeneity of soft-tissue tumors. Preliminary data suggest that two biologically distinct groups of masses may be separable on the basis of quantitative velocity-based estimates of tumor vascularity as obtained from color Doppler sonography.

Adolescent↗
PubMed1998

Pediatric hip effusions: evaluation with power Doppler sonography.

PURPOSE: To determine if power Doppler sonography allows differentiation of infectious from noninfectious hip effusions and thereby obviates joint aspiration. MATERIALS AND METHODS: Twenty-nine consecutive children (30 hips) with sonographically identified hip effusion were prospectively evaluated with power Doppler sonography. Both hips were evaluated in each patient by using identical imaging parameters and were then compared. Medical charts were reviewed to determine the eventual diagnosis. RESULTS: At power Doppler sonography, none of 16 patients with transient synovitis had increased flow in the affected hip compared with the contralateral normal hip. Of 11 patients with septic arthritis, one had asymmetric increased flow, and two others, in whom contralateral comparison images were limited, had probable increased flow. Three patients with miscellaneous diagnoses had symmetric normal flow. CONCLUSION: Because power Doppler sonograms did not depict increased flow in most patients with septic arthritis, normal flow on power Doppler sonograms does not allow exclusion of septic arthritis and should not preclude aspiration when clinically warranted.

Adolescent↗
PubMed1998

Sonographic detection of xanthomas in normal-sized Achilles' tendons of individuals with heterozygous familial hypercholesterolemia.

OBJECTIVE: The objective of this study was to evaluate how well high-frequency linear array sonography reveals xanthomas in the Achilles' tendons of individuals with heterozygous familial hypercholesterolemia before the xanthomas enlarge the tendons enough to become palpable. SUBJECTS AND METHODS: Both Achilles' tendons of 23 individuals (18 female and five male; age range, 16-69 years old) who had heterozygous familial hypercholesterolemia but no clinically apparent Achilles' tendon xanthomas were studied with high-frequency linear array sonography. Hypoechoic areas, consistent with xanthomas, were noted. RESULTS: Xanthomas were revealed in 36 (78%) of 46 tendons and 19 (83%) of 23 individuals. CONCLUSION: Sonography reveals Achilles' tendon xanthomas in many individuals with heterozygous familial hypercholesterolemia before the xanthomas are clinically apparent. Because tendon xanthomas in a hypercholesterolemic individual are essentially pathognomonic of heterozygous familial hypercholesterolemia and are a mainstay in its diagnosis, our study suggests that sonography is useful in the early diagnosis of heterozygous familial hypercholesterolemia.

Achilles Tendon↗
PubMed1998

Power Doppler sonography in tenosynovitis: significance of the peritendinous hypoechoic rim.

The aim of this study was to evaluate the ability of power Doppler sonography to distinguish between hypoechoic fluid and synovium in patients with suspected tenosynovitis. Gray scale sonography and power Doppler sonography were performed on 26 tendons in 24 patients with tenosynovitis and 30 tendons in five asymptomatic volunteers. Peritendinous blood flow was graded on a scale of 0 to 3 and the percentage of the hypoechoic rim that contained blood flow was also noted. In the symptomatic group, flow was demonstrated in more than 50% of the peritendinous hypoechoic rim in 17 of 26 tendons. A positive correlation was found between the power Doppler sonographic grade and the percentage of the rim that had flow. These results suggest that a significant proportion of the hypoechoic rim probably represents vascularized synovium rather than complex fluid.

Adult↗
PubMed1997

Ultrasonic characterization of in vitro osteoarthritic articular cartilage with validation by confocal microscopy.

The majority of adults over the age of 65 y develop osteoarthritis (OA), a joint disease characterized by degeneration of articular cartilage and subchondral sclerosis. Early in the disease, the articular cartilage surface begins to change histologically from a smooth to a rough or fibrillated appearance. A prerequisite for any chondroprotective pharmacological intervention is detection of OA in its preclinical phase. Current diagnostic imaging modalities, such as radiographs or (nuclear) magnetic resonance imaging, either cannot directly image the cartilage surface or lack sufficient resolution to detect surface fibrillations. We have developed an ultrasonic technique that can be used to characterize these surface fibrillations directly. We present our in vitro results with validation by laser-based confocal microscopic imaging.

Adult↗
PubMed1997

Normalizing fractional moving blood volume estimates with power Doppler US: defining a stable intravascular point with the cumulative power distribution function.

PURPOSE: To normalize the power Doppler ultrasound (US) signal to the expected signal from 100% blood in the calculation of a fractional moving blood volume estimate. MATERIALS AND METHODS: To locate the signal from flowing blood with a consistent backscatter coefficient, the authors estimated the knee of the cumulative Doppler power distribution function. They used a flow-tube phantom to test the use of this knee to locate a radial position that would fall into a region of high shear stress and minimal rouleaux formation. They also studied how well the method normalized fractional moving blood volume estimates of the right renal cortex in a volunteer when simulating different body habitus and in a group of six healthy volunteers to estimate variability. RESULTS: Over five flow velocities and over undersaturated to severely oversaturated receiver gains, the calculated flow-tube area was a mean 89% +/- 7 (+/- standard deviation) of a standard. In humans, the technique normalized the fractional moving blood volume estimates over an 8-dB receiver gain variation; the mean +/- standard deviation of fractional moving blood volume estimates for the six volunteers was 37.6% +/- 3.6. CONCLUSION: Vascularity estimates with power Doppler US are feasible with a normalization scheme based on the cumulative Doppler power distribution function.

Adult↗
PubMed1997

Power Doppler sonography: use in measuring alterations in muscle blood volume after exercise.

OBJECTIVE: The purpose of this study was to show the ability of power Doppler sonography (PDS) to evaluate exercise-induced changes in muscle blood volume. SUBJECTS AND METHODS: We evaluated 20 biceps muscles with PDS in 10 healthy volunteers before and after they underwent a standardized exercise protocol. Intramuscular blood volume was qualitatively analyzed using a subjective scoring system to evaluate vascular conspicuity, comparing sonograms obtained before and after exercise. We also collected preliminary data on the quantification of estimated fractional moving blood volume (EFMBV) measured on sonograms obtained in eight biceps muscles of five volunteers. Assessment of significance was calculated using a Wilcoxon signed-rank correlation of significance. The stability of relative changes in EFMBV was also assessed with measurements performed at three different times in five healthy volunteers. RESULTS: With exercise, all 20 biceps muscles showed a significant subjective increase in apparent vascularity (p < .0005). Likewise, preliminary data on EFMBV showed significant increases (p < .01) between baseline and peak exercise values (mean, 470%; range, 180-900%). CONCLUSION: PDS revealed marked increases in intramuscular vascular conspicuity after exercise. EFMBV provided a potentially useful parameter to document such increases quantitatively.

Adult↗
PubMed1997

Technetium-99m-MDP uptake in hilar lymph nodes in sarcoidosis.

We describe a patient with unexplained hypercalcemia who under went bone scintigraphy, which demonstrated marked tracer uptake within the hilar lymph nodes. The pattern strongly suggested sarcoidosis, which was subsequently confirmed by bronchoscopy-directed biopsy.

Adult↗