Search PubMed⌕ Search

Biomedical subjects

R Rothe

Publications and source records attributed to R Rothe.

At least 37 records · Page 2Linked to original sources
PubMed1981

[The natural course of atrial septal defects].

61 patients at the age of 18 to 70 years with untreated atrial septum defect were examined 7.5 to 21 (on the average 10.5) years after the first recognition. Subjective symptomatology, clinical picture, size of the heart, mean pressure of the pulmonary artery and shunt volume at the beginning and at the end of the period of observation were analysed. The results reveal an above all favourable prognosis of the congenital malformation. In a course without complications an age can be reached adequate to the average life-expectance. After the 40th year of age, however, in 75% of the patients complaints appeared or their number increased. With growing age the size of the heart and the frequency of disturbances of the cardiac rhythm increased. In the small left-to right-shunt (less than 30% of the pulmonary flow) in the majority of the cases (85%) the prognosis proved to be good. Even in shunt volumes of more than 60% in half of the patients no essential deterioration developed in the period of observation. No clear relations were found between the mean pressure of the pulmonary artery and the clinical degree of severity. The indication to the operative correction of the atrial septum defect diagnosed only at the adult age demands a critical individual judgement, in which case apart from the haemodynamic parameters anamnesis and clinical findings within a cardiological observation of the course are of particular importance.

Adolescent↗
PubMed1980

[Determination of delta-aminolevulinic acid dehydratase in venous and capillary blood and delta-aminolevulinic acid in urine of lead-exposed workers].

Delta-aminolaevulinic acid dehydrogenase is a key enzyme in porphyrin synthesis which catalyses the formation of porphobilinogens from two molecules of delta-aminolaevulinic acid. Delta-aminolaevulinic acid dehydratase is a sulphhydryl group enzyme which is inhibited by lead ions and other heavy metal ions. A method has been devised on that basis to determine industrial and ecological lead intoxication. While correlations have been statistically secured between airborne lead concentration, biochemical reactions, inhibition of delta-aminolaevulinic acid dehydratase, and increased discharge of delta-aminolaevulinic acid, determination of enzyme activity cannot be used in situations of high exposure to lead, because inhibition was found to be too strong, and dose-action relationship between actual exposure and biological response were found to provide no information with relevance to industrial medicine. A method less sensitive than determination of delta-aminolaevulinic acid should be preferred for monitoring of higher lead concentrations. Determination of delta-aminolaevulinic acid dehydratase activity is applicable only to low or usual lead exposure.

Adult↗
PubMed1980

Combined action of hepatotoxic substances and increased environmental temperature on the liver of rats.

Male albino rats were orally treated in a single dose with 40 mg allyl alcohol/kg or 50 mg 4,4'-methylenedianilline/kg, or 100 mg 1,1,2,2-tetrachloroethane/kg, or 400 mg carbon tetrachloride/kg, or 800 mg chloroforme/kg, immediately after-wards exposed to increased temperature (35 degrees C, 50% RH, 4 h), and examined 20--22 hours later. Under these conditions, only carbon tetrachloride led to a more intensified changes manifesting themselves in changes of the serum enzymes LAP, ALAT, and GLDH, as well as in liver histology. The liver lesions, caused by the substances mentioned, reacted to an additional thermal strain in a comparable manner as the LD50-values determined under identical exposure conditions. The temperature-dependent enhancement of the carbon tetrachloride hepatotoxicity is ascribed to an intensification of liver peroxidation processes due to increased core temperature.

1-Propanol↗
PubMed1979

[Comparative examination of endocrine ophthalmopathy by means of ultrasonography, computerized tomography and fish bioassay].

In 35 patients with Graves' ophthalmopathy (GO) thyroid function was tested by T3-RIA, T4-RIA, TBI, TRH-test, thyroid scanning, and determination of thyroid autoantibodies. Additional ultrasonography (A-scan), computed tomography (CT) of the orbit, and the determination of an exophthalmogenic serum activity in fish bioassay was performed. Typical alterations for GO were observed in 26 cases with ultrasonography. CT showed an enlargement of medial and/or lateral rectus muscles in 24 of 33 patients, and in 17 cases a region of high density in the apex of the muscle cone. The density of retrobulbar fat after i.v. injection of contrast medium did not differ significantly from that observed in normal men. Characteristic signs of GO were not detected in only 2 cases using both methods together. Exophthalmogenic serum activity was found in the IgG fraction of serum protein. The incidence rate was high (69%), but for diagnostic purpose the fish bioassay cannot be recommended.

Adult↗
PubMed1978

Computerized tomography and nuclear imaging of the liver: a comparative study in 83 cases.

This study was performed to comparatively assess the diagnostic accuracy of computerized tomography (CT) and nuclear liver-scanning in detecting and defining circumscript and diffuse liver diseases in 83 patients. Presence or absence of liver diseases was assessed based on the results of invasive diagnostic procedures such as biopsy, laparoscopy, laparotomy, and/or autopsy. The percentage of true negative diagnoses was 94% for CT and 91% for static gamma-imaging (n = 33). With a rate of 94% true positive diagnoses, CT proved to be superior to gamma imaging with radiocolloids (81% true positives) in diagnosing circumscript liver diseases (n = 31). In addition. CT was superior to nuclear imaging regarding discrimination of number and size of space-occupying lesions within the liver. In contrast to nuclear screening, CT scans were pathognomonic to some circumscript liver diseases such as cysts, metastases, and perhaps echinococciasis. This was also true for obstructive jaundice. Nuclear imaging, because it reflects a sort of liver function, was superior with cirrhosis, whereas CT showed only alterations in the size and shape of the liver and spleen.

Abscess↗
PubMed1978

Diagnostic accuracy of CT in circumscript liver disease.

To evaluate the accuracy of CT in diagnosing circumscript liver disease, CT findings in 105 patients were compared to the results of invasive diagnostic procedures (laparoscopy, laparotomy, and autopsy). In all patients at least one of these procedures was performed in addition to CT. CT proved to be a valuable noninvasive method in detecting and differentiating circumscript liver lesions such us metastases, primary liver tumors, solitary cysts and polycystic disease, abscesses, and echinococciasis. The 10% rate of false positive and false negative diagnoses indicates the limitations of the method.

Autopsy↗
PubMed1977

[Computerised tomography of the trunk-a first report (author's transl)].

One thousand patients have been examined with the body scanner and a preliminary report is presented on the value of this method in the examination of abdomen and the thorax. Unlike other radiological procedures, computerised tomography is often able to demonstrate disease states directly and not only as a result of their effect on neighbouring structures. It provides a non-invasive means for achieving a diagnosis, for therapy planning and for control of treatment of space-occupying lesions within the trunk. Its role can only be defined after a systematic comparision with conventional diagnostic procedures.

Bronchial Neoplasms↗
PubMed1977

[Special indications for using the whole body scanner (author's transl)].

In addition to the role of the body scanner in the diagnosis of diseases of the body cavity and parenchymal organs, the authors review the scope and indications for using whole body computer tomography in special situations. Examples are given of its use in the diagnosis of tumours in the vicinity of the skull base, in the orbits, the facial skeleton, soft tissue tumours, bone diseases and CT-controlled biopsies.

Adult↗