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Biomedical subjects

R Richter

Publications and source records attributed to R Richter.

At least 253 records · Page 14Linked to original sources
PubMed1977

Significance of oscillation frequency in intrapartum fetal monitoring.

Until now, no statistical data have been available on the significance of the frequency of FHR oscillations. In order to evaluate the relation between oscillation frequency and neonatal outcome, the last 30 minutes of 812 FHR records were analyzed with respect to the number of 812 FHR records were analyzed with respect to the number of oscillations per minute only. Close correlations were found between slow oscillations below 2 per minute and the arterial cord pH as well as the Apgar scores after 1 and 5 minutes, respectively. No relation could be established between any oscillation frequency above 2 per minute and the measures of the neonatal outcome. In discussing the results, slow oscillations are suggested to be identical with the sinusoidal FHR. Emphasis is made that for an appropriate pattern recognition, true beat-to-beat recording is required, avoiding any averaging procedure.

Apgar Score↗
PubMed1977

Heterologous reactivity of in vitro cultured mouse cells with natural human serum antibodies.

Studies employing the cytotoxic and immunofluorescence tests revealed presence of natural human serum antibodies in the serum of various human donors, which reacted with normal and pathologic mouse cells cultivated in vitro. This reactivity was due to presence on the cell surface of heterologous HMAg antigen incorporated into the cell membrane from calf serum. Immunofluorescence studies demonstrated localization of this antigen on the cell surface. Absorption of human sera with calf serum or with lyophilized cow's milk abolished or markedly weakened the ability of these sera to react with cultured mouse cells.

Animals↗
PubMed1977

The heart rate response as an indicator of changes in activation induced by alcohol.

This experiment was conducted in order to examine different alcohol-induced states of activation as indicated by the acoustic evoked heart rate response (HRR). Twelve healthy male subjects received 0.7 g/kg alcohol in one session of a cross-over designed experiment. In the control session no alcohol was given. The measurements of three parameters of the heart rate response as well as the self-assessments of mood were repeated five times along the course of the venous blood alcohol concentration. Significant depressant alcohol effects were reflected in a decrease in the HRR acceleration as well as in a decrease in vitality, vigilance, and self-estimated startle reaction. Stimulating effects could be observed in an increase of the mean heart rate and the second HRR deceleration. We conclude that different alcohol-induced states of activiation represent different patterns of inhibitory and facilitatory processes, each manifesting itself in different parameters. The results suggest three major components of alcohol action: 1) an inhibition release with immediate onset,2) a slower processing inhitition,3) attention focussing as a compensatory response to inhibition.

Acoustic Stimulation↗
PubMed1976

[The time-course of alcohol induced changes in self-rating-scales of mood (author's transl)].

Alcohol was administered in a dose of 0.77 g per kg bodyweight to 16 healthy male subjects in a cross-over-design. A study was made of a number of psychological and physiological variables to determine the modifications that accompany the alcohol-induced changes in the orienting response to an auditory stimulus. Five determinations were made at intervals following a dose of alcohol and five in a control session when no alcohol was given. The results obtained for the psychological variables (self-ratings of the intensity of intoxication and the degree of being startled by the first stimulus; and self-assessment of mood) show alcohol to have stimulant as well as depressant effects. Some of the variables show stimulant effects, mainly at the beginning of the absorption phase, whereas other variables show depressant effects, both in the absorption phase and the postabsorption phase. Changes in physiological variables (such as parameters of electrodermal activity and of the heart rate response) support these findings. The simultaneous presence of both stimulant and depressant effects is pointed out as well as the difficulties in describing these findings in terms of a unidimensional model of activation.

Adult↗
PubMed1976

AKR mouse leukemic cells in tissue culture. II. Immunologic studies on the AKR 87 cell line.

The continuous AKR 87 cell line was derived from the thymus and spleen of AKR mice with spontaneous leukemia. Previous studies showed that the line has retained the original morphologic features of leukemic cells, reacts positively in the XC test, and produces virus particles of type C morphology. The present paper presents an immunologic characterization of cells of the AKR 87 line and of the virus produced by them, in comparison with the cells of spontaneous leukemia of AKR mice, TGV line productively infected with Gross virus, and normal mouse tissues. Results of the hemagglutination test, immunoprecipitation in agar gel, cytotoxic test and immunofluorescence indicate that the AKR 87 line produces virus antigen of the Gross type.

AKR murine leukemia virus↗
PubMed1976

[The significance of gestational age in evaluating the antepartal cardiotokogram (author's transl)].

The influence of gestational age on the probable meaning of features in the antepartal CTG which are not clearly pathological was investigated in 232 births in 1973/74. The umbilical artery pH was significantly lower among premature infants exhibiting abnormal, than among those exhibiting normal CTG patterns. No similar difference was found in term or overdue births. The clinical diagnosis of neonatal condition using the Apgar scheme confirmed biochemical findings: The frequency of depressed babies is in turn clearly higher in cases with abnormal antepartal CTG patterns. It is assumed that the reason for this is the higher sensitivity of premature babies to haemodynamic disturbances. Thus, it follows that premature babies exhibiting antepartal patterns which are not completely normal require close observation.

Apgar Score↗
PubMed1976

[Personality-specfic action of a tranquilizer (author's transl)].

23 emotionally lable and 22 emotionally stable subjects wefe selected from a total smaple of 147 students by three personality inventories (FPI, GT, MPI). In a 2(3)-factor design the following effects of a single dose of 1.5 mg bromazepam p.o. against placebo were found: whereas the fine-motor activity (tapping, line-tracing) was stabilized independently of personality traits, the performance in attention tests (d2, choice-reaction time) was decreased in the emotionally stable group. In the emotionally lable group, i.e. in those subjects for whom bromazepam could therapeutically be indicated, an advantageous effect on performance in these tests was possible. The following variables were not affected by personality or medication: after-image of spiral rotor, critical flicker fusion (CFF), taking-task

Affect↗
PubMed1975

[The impairment of the ability to drive with blood alcohol concentrations of 0,5 per mille. A review of the literature].

As a contribution to the discussion surrounding reduction of the 0.08% limit, empirical data concerning the influence of blood alcohol levels around 0.05% on driving ability are reviewed. The papers reviewed, all of which satisfy the usual methodological standards, show that in the 500 subjects investigated there was already marked impairment of driving ability below blood alcohol levlels of 0.08%. Marked impairment is particularly apparent in those abilities which, with regard to the complexity of the perceptual and psychomotor patterns involved, are most relevant to the real driving situation: --decreased performance of simple and complex perceptual mechanisms, attention and vigilance; --decreased performance of psychomotor skills, resulting in impaired control of the vehicle in the real traffic situation. It can be concluded that even at these low blood alcohol levels an increased accident risk is to be expected.

Accidents, Traffic↗