Search PubMed⌕ Search

Biomedical subjects

R Richter

Publications and source records attributed to R Richter.

At least 217 records · Page 12Linked to original sources
PubMed1980

Immunological reactivity of glycoprotein antigens from human lung cancers.

Glycoprotein antigens were extracted with perchloric acid (PCA) from the 14 individual lung anaplastic cancers and 4 lung adenocarcinomas and their antigenic activity was compared with carcinoembryonic antigen (CEA) isolated from liver metastases of colon cancer. The studies were performed by double immunodiffusion, immunoelectrophoresis and radioimmunoassay, using the specific immune sera against PCA-extracted glycoproteins of lung anaplastic cancer (anti-80 PCA-CaLu), and also anti-CEA, anti-AFP, and anti-alpha 1-acid glycoprotein sera. The existence of at least three groups of antigens in lung cancers was demonstrated, i. e. CEA-like antigen, group antigen characteristic for most of the lung anaplastic cancers and lung adenocarcinomas non-related to CEA and antigen(s) detectable only in some of anaplastic cancers. Moreover antigen of alpha 1-acid glycoprotein reactivity was detected in all lung cancers studied.

Adenocarcinoma↗
PubMed1980

[The clinical significance of accelerations in intrapartum fetal heart rate monitoring (author's transl)].

Fetuses failing to exhibit accelerations in antepartum fetal heart rate (FHR) testing are considered to be at risk. However, until now the prognostic value of intrapartum FHR-accelerations is not known. The occurrence or absence of accelerations during the last 30 minutes preceding delivery was compared in 812 intrapartum FHR-records with FHR-score (3), umbilical cord artery pH, one and five minute Apgar score values. When accelerations were absent during the last 30 minutes before delivery, severe neonatal depression was observed in 10 per cent of neonates as compared to 5 per cent when accelerations were present. This difference is statistically significant. If accelerations were observed, no correlation was found between rate of FHR increase, amplitude, or duration of accelerations, and fetal or neonatal state.

Apgar Score↗
PubMed1979

[Demonstration of left-ventricular contraction anomalies with the two-dimensional sector-scanner (author's transl)].

Echocardiographic findings were compared with those obtained by cardiac catheterisation in 134 patients. Echocardiography was performed in the standard plane of the long and short axes, as well as from the cardiac apex. After dividing the left ventricle into several segments wall movement was measured in them and compared with those obtained by ventricular angiography in the right and left anterior oblique positions. It was found that in patients with left-ventricular aneurysm, proven by left ventricular angio, there was complete conformity with regard to localisation and extent of the aneurysm between the two methods of investigation. In this group 79% of the demonstrated segments could be adequately assessed and, in 91%, agreed with the radiological findings. In the group of patients without aneurysm only 68% of the segments could be adequately assessed, and 77% correctly assessed wall movement when compared with the laevocardiogram. Tracing recorded from the cardiac apex gave especially good results in demonstrating the ventricle and its segments.

Adult↗
PubMed1979

Seasonality in biochemical determinations: a source of variance and a clue to the temporal incidence of affective illness.

Systematic investigation of seasonal variations revealed unimodal annual rhythms in platelet serotonin uptake and DBH activity, bimodal seasonal rhythms in free and total tryptophan, melatonin, and platelet serotonin, and significant fluctuations of higher frequency in platelet MAO activity and protein. The methodological importance of seasonality is emphasized by the fact that the seasonal changes noted were often greater than differences previously found in the same parameters between depressive patients and controls. Since seasonal rhythms are circadian in origin, impairment of a central 24-hour biological clock could provide a common basis for circadian rhythm disturbances and seasonality in affective disorders.

Adult↗
PubMed1979

The treatment of threatened premature labor by betamimetic drugs: a comparison of fenoterol and ritodrine.

Studies have shown that, in patients with threatened premature labor, fenoterol and ritodrine are effective agents for delaying its onset. However, the side-effects of these drugs can be a problem. Among 133 patients studied, the intravenous administration of either agent caused marked tachycardia (but no changes in blood pressure) and a high incidence of palpitations, trembling, and nausea. During oral therapy, subjective symptoms were less frequent. The addition of the calcium antagonist, iproveratril, to the therapeutic regimen did not influence the effectiveness of the 2 agents or the incidence of their adverse side-effects.

Adrenergic beta-Agonists↗
PubMed1979

[Forceps deliveries in epidural or general anesthesia (author's transl)].

It was the aim the present study to evaluate maternal morbidity and fetal outcome of 832 pelvic outlet forceps deliveries during the years 1974 through 1977 with special reference to the method of anesthesia (Epidural anesthesia (EA) with Bupivacain 0,5% or general anesthesia (GA) with Methohexital-Na and Succinylcholin). Maternal vaginal and/or cervical injuries were seen significantly (p less than 0,001) more often in the forceps group than in spontaneous, vacuum, or breech deliveries. Vaginal injuries occurred less often (p less than 0,01) in the EA- than in the GA-group. Forceps deliveries were not associated with increased maternal morbidity in fetuses weighing 3750gr or more. The cardiotocography scores (Hammacher et al. 1974) of the 30 minutes preceeding delivery (final scores) were better with EA than with GA (p less than 0,01). Arterial cord pH and 1 minute Apgar values were similar in both groups. The same was true for fetuses with a birthweight of 3750gr or more. The time for cervical dilatation from 7 to 10 cm and duration of the second stage of labor did not influence maternal morbidity or fetal outcome, regardless of the method of anesthesia.

Anesthesia, Epidural↗
PubMed1979

Correlation between immunohistochemical localization of carcinoembryonic antigen (CEA) and histological estimation of carcinomas, normal mucosae and lymph nodes of the digestive tract in humans.

The localization of the carcinoembryonic antigen (CEA) in carcinomas and mucosae of the digestive tract in humans and in mesenteric lymph nodes was studied by indirect immunofluorescence. In colonic and gastric adenocarcinomas, CEA had typical centroglandular localization. Cytoplasmic localization of the CEA was seen in invasive cancer cells having lost their glandular organization. CEA was also present in colonic and gastric mucosae surrounding the tumor. In gastric mucosa obtained at autopsy from subjects with nonneoplastic diseases, CEA was found only in glands having undergone intestinal metaplasia. In lymph nodes of cancer patients CEA was always present in metastatic cells and in germinal centers. Characteristic localization of CEA in germinal centers of metastatic and nonmetastatic lymph nodes could suggest the presence of CEA-anti-CEA immune complexes.

Adenocarcinoma↗
PubMed1979

Differences in the purification effect of carcinoembryonic antigen (CEA) from the three different hepatic metastases of rectum carcinoma.

Carcinoembryonic actigen (CEA) was purified from three liver metastases of carcinoma recti by a conventional procedure involving perchloric acid extraction of tumor tissue and fractionation of the extract by gel filtrations on Sepharose 4B and Sephadex G-200. The preparations obtained showed a different degree of heterogeneity in SDS-polyacrylamide gel electrophoresis and crossed immunoelectrophoresis, and also a different antigenic activity. One of preparations obtained was a homogeneous CEA by all these criteria, and two others showed heterogeneity and lower antigenic activity. The most heterogeneous CEA preparation was further purified by the affinity chromatography on Concanavalin A-Sepharose 4B and by DEAE-Sephadex A-50 chromatography and the usefulness of these procedures for purification of CEA is compared.

Carcinoembryonic Antigen↗
PubMed1979

[Intrapartum fetal heart rate patterns and fetal outcome: prediction of newborn depression (author's transl)].

A statistically significant correlation exists between patterns of fetal heart rate (FHR) and neonatal state. However, the prognostic value of alterations of FHR for the individual has not been established. In 812 deliveries, we analyzed FHR tracings of the 30 minutes preceding delivery and correlated 6 characteristics of baseline, 10 of floating line and 6 of oscillation type with the incidence of severe acidosis (pH of umbilical cord artery less than or equal to 7.10) and low Apgar scores (one minute Apgar score less than or equal to 6). The exact risk for neonatal depression was calculated for each pattern of FHR. A high rate of depressed infants could be expected when the following alterations of FHR were seen during the last 30 minutes before delivery:--mild tachycardia, severe bradycardia,--severe variable decelerations, uniform late decelerations,--oscillation frequency less than 2 per minute independent of oscillation amplitude.

Acidosis↗
PubMed1979

CEA-like antigens in different histologic types of human lung carcinoma.

Comparative studies on the presence and immunological reactivity of CEA and CEA-like antigens in lung and digestive tract cancers were performed. Specific goat and rabbit anti-CEA immune sera were used. Immunofluorescence studies revealed in histologically different types of the lung carcinomas the presence of the cross reacting antigen with classical CEA. Absorption procedures, and double diffusion tests have shown the existence of two at least antigenic determinants in CEA molecule: 1. the determinant specific for the lower parts of the digestive tract cancers not found in the lung carcinomas, and 2. the determinant common for the lung, and the digestive tract cancers.

Adenocarcinoma↗