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Biomedical subjects

R Reid

Publications and source records attributed to R Reid.

At least 235 records · Page 13Linked to original sources
PubMed1981

Xanthogranulomatous cholecystitis: report of seven cases.

Seven cases of xanthogranulomatous cholecystitis collected over a 16-year period are reported. Their clinical presentation is that of a conventional chronic inflammatory gallbladder disease. Sometimes a mass lesion is mimicked radiographically and during surgery. The distinctive tissue reaction and cholesterol content of the lesion are emphasized in this study. Chronic infection and concurrent calculi have been implicated in the pathogenesis.

Adult↗
PubMed1980

Incorporation of radioactive tubulin into microtubules at steady state. Experimental and theoretical analyses of diffusional and directional flux.

Subunit flux into porcine brain microtubules at steady state has been studied using both radioactive guanine nucleotide and a radioactive tubulin dimer, [3H]ethyltubulin, which is obtained by a reductive ethylation (Zeeberg, B., Cheek, J., and Caplow, M., (1980) Anal. Biochem. 104, 321--327). We have also determined the molecular rate constants for steady state dimer loss from and addition to the microtubule. This is the first study where the rate for flux of radioactive subunits at steady state has been correlated with the measured molecular rate constants. Also, we derive a theoretical analysis of the observed flux of subunits into a polymer at steady state in pulse and chase experiments; this is used to relate the flux and molecular rate constant to a steady state model. Analysis of our results shows that, at steady state, there is only a small difference in the number of assembly and disassembly events at a given microtubule end (as compared with the total number of events at both ends) in a unit of time; predominant opposite end assembly-disassembly (Margolis, R. L., and Wilson, L. (1978) Cell 13, 1--8) is, therefore, ruled out. The almost complete absence of opposite end assembly-disassembly in the steady state provides a means for very efficient regulation of the microtubule network in vivo, since a small modulation in the relative magnitudes of the molecular rate constants can increase the subunit flux dramatically.

Animals↗
PubMed1980

Tattoo removal by CO laser dermabrasion.

A method of tattoo removal by partial-thickness dermal ablation, using a microsurgically adapted CO2 laser, is described. Provided that meticulous attention is paid to each detail of surgical technique, the procedure can be relied upon to produce good cosmetic results with scant risk of complications.

Adult↗
PubMed1980

Noncondylomatous cervical wart virus infection.

Human papillomavirus (HPV) infections of the genital tract frequently involve cervical epithelium and produce a macroscopically flat lesion that the authors have called noncondylomatous cervical wart virus infection (NCWVI). Over a 6-month period, 92 of 7281 routine cervical smears (1.3%) and 46 of 183 colposcopically directed punch biopsies (25%) showed morphologic evidence of wart virus infection. The etiologic role of HPV was confirmed by the demonstration of virus particles in 24 of 53 cases (45%) examined by electron microscopy. The colposcopic features of NCWVI consist principally of epithelial opacity and vascular atypia, leading to frequent confusion with cervical intraepithelial neoplasia. Differences in surface contour, color, vascular patterns, and topography generally permit colposcopic differentiation. These 2 conditions sometimes coexist; whether the association is causal or casual in not presently known.

Colposcopy↗
PubMed1979

Rapid diagnosis of beta-haemolytic streptococcus group B endocarditis by buffy-coat examination and gas-liquid chromatography.

A semicomatose 34-year-old man had fever, heart murmur, and multiple gangrenous lesions. Several blood cultures were negative. Cultures of the heart valve grew beta-haemolytic streptococcus group B. The organism was seen in buffy-coat examination of the venous blood. The gas-liquid chromatogram of the serum was different from those of normal controls and of patients with invasive candida infection; it closely mimicked the one obtained from the organism itself. These studies promise to be valuable diagnostic adjuncts.

Adult↗
PubMed1978

Closure of the bladder neck in patients undergoing continent vesicostomy for urinary incontinence.

The continent vesicostomy has been done on 24 patients, 10 of whom had severe urinary incontinence requiring closure of the bladder neck or urethra as well. Therefore, the bladder was converted to a closed cavity and intermittent catheterization is done through an abdominal stoma. No dressings or appliances are necessary. Bladder neck (or urethral) closure was successful in 8 of the 10 patients. One of the failures had been incontinent and was rendered continent on attempted bladder neck closure and there is urethral leakage at night in the other patient. Intermittent catheterization through a vesicostomy stoma has been cleaner and more aesthetically pleasing to the patients. The bladder neck closure has resulted in a dry perineum with fewer skin problems.

Adolescent↗
PubMed1977

Xanthogranulomatous pyelonephritis in children.

Xanthogranulomatous pyelonephritis in children, contrary to adult onset, rarely is associated with non-function or calcification. The lesion is predominantly on the left side in children. There appears to be a normal humoral but temporarily impaired cellular immune response in addition to sustained depression of polymorphonuclear chemotaxis. The etiology of this is uncertain but may be attributed partially to hyperosmolarity of serum and urine, and to leukocyte specific antinuclear antibodies. The presence of leukocyte specific antinuclear antibody or cold agglutining may interfere with normal phagocyte chemotaxis requiring tissue macrophages to produce a xanthogranulomatous reaction to bacterial invasion.

Cell Movement↗
PubMed1977

A case of nephrobronchial and colonobronchial fistula presenting as lung abscess.

A nephrobronchial fistula is an uncommon clinical entity and perinephric abscess in the most common etiological lesion. At times, pulmonary symptoms may dominate the clinical picture and the diagnosis of an associated renal lesion may be overlooked. An unusual case of a coexisting nephrobronchial and colonobronchial fistula is reported. The patient had been treated for chronic lung abscess for 4 years before the final diagnosis was made.

Bronchial Fistula↗
PubMed1976

Fetal complications of obstetric cholestasis.

Among 56 pregnancies complicated by obstetric cholestasis five intrauterine deaths and one neonatal death occurred between 33 and 39 weeks, and a further six infants required urgent delivery for intrapartum asphyxia. Eighteen spontaneous premature deliveries occurred. Five mothers required specific treatment for unexplained postpartum haemorrhage. Cholestasis of pregnancy is therefore not a condition benign to the fetus, and it may contribute to increased maternal morbidity.

Adult↗
PubMed1976

A receptor-like testosterone-binding protein in ovaries from estrogen-stimulated hypophysectomized immature female rats.

A soluble thermolabile protein with many characteristics of an androgen receptor has been demonstrated for the first time in the cytosol (100,000 X g supernatant) of estrogen-stimulated ovaries from hypophysectomized immature female rats (HIFR) treated with diethylstilbestrol in Silastic capsules (DESC). This binding protein is organ-specific and androgen-specific, has a high affinity with a Kd of 2.4 X 10(-9)M for testosterone, and is saturable with 2.1 X 10(-13) moles of binding sites per mg cytosol protein. The number of binding sites is linear with cytosol protein concentration and the binding protein sediments at 7-8 S on sucrose gradients. Estradiol is an effective inhibitor of testosterone binding. A role for this testosterone-binding protein as an effector of ovarian morphologic change is hypothesized.

Animals↗