Biomedical subjects
R Rath
Publications and source records attributed to R Rath.
p-tert.-Butylphenol formaldehyde and other causes of shoe dermatitis.
Because p-tert.-butylphenolformaldehyde-free shoes are unavailable in the Dutch market we had to have shoes made of alternative materials for 13 patients reacting to this resin. These alternative materials consisted of leather samples prepared with various tanning agents, counters (heel stiffeners), stitching yarns, adhesives, etc. The composition of these alternative materials was kept a secret. New shoes were composed of materials to which the patient had shown negative reactions. These shoes are well tolerated. Only one patient reacted to virtually all materials tested. She may have an excited skin syndrome. She will be tested in the near future with the necessary materials applied one by one to find out whether this is true. Up to present we have encountered only a few shoe positive patients who have neither reacted to the resin, nor to a series of alternative adhesives. These patients will be studied in more detail as to the origin of their dermatitis.
[Fenfluramin in the therapy of obesity (author's transl)].
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Lacrimal system dacryoliths.
Seventy consecutive patients undergoing dacryocystorhinostomy for chronic dacryocystitis or dacryostenosis were analyzed. Lacrimal sac stones were found in 11 patients for an incidence of 16%. All stones were studied histopathologically and six of these stones demonstrated morphological characteristics compatible with fungus. Two stones were cultured and one of these grew aerobes with the other growing fungi only. A series of nine patients with canalicular dacryoliths was analyzed. All patients were studied clinically and bacteriologically. No fungus was found on any of these cases. Aerobic cultures were positive in two patients. All patients with canalicular stones grew anaerobes with arachnia propionica and fusobacterium species predominating. The treatment for both problems is recognition and removal of the stones.
Relation to body fat to age in the Czech population.
Density and percentage of fat in the body were investigated in 403 females and 356 males of Czech population using hydrostatic weighing. The group was divided into four age subgroups ranging from 17 through 22, 23 through 29, 30 through 39 and 40 through 49 years. Fat values were found to increase with age, growing in females and males between the ages of 17 to 49 years from 27.1 to 35.4 and from 16.3 to 26%, respectively. In both sexes, the highest difference in the percentage of fat was observed between the second and third decennium. Body weight was also seen to increase with age up to 40 years of age. On the other hand, from 40 through 49 years a decrease in weight was seen both in male and female means, with the body heights also less in older subjects. The values observed, particularly in females, exceed those reported as a rule in other populations. This is accounted for by nutritional factors such as the amount of calories and composition of food and possibly also by the effect of the genetically given somatotype.
Energy metabolism enzymes in adipose tissue and in muscle in obesity.
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Free fatty acid release from human adipose tissue in relation to obesity -- effect of isoprenaline.
The capacity to release non-esterified acids and glycerol from the abdominal subcutaneous adipose tissue into a medium containing different concentrations of isoprenaline was studied in 21 adults with different body weight (14 obese, 7 controls). The obese had a significantly lower maximum adipokinetic capacity (expressed as pD2) than controls. The significant decrease in pD2 in the obese was found to depend on the stabilization of the weight while the dynamic pD2 stage values of the obese did not differ from those of controls. The hypothesis is expressed that lower pD2 values may be related to the smaller decrease of body fat during weight reduction.
The effect of mazindol on metabolic and regulatory changes in obese women during weight reduction.
The effect of mazindol (1 mg/day) on some metabolic and regulatory values was investigated in ten adult obese women and compared with the same number of controls during weight reduction in hospital (a five-times repeated cycle of 5 days complete starvation and 3 days on a 500 kcal(2.1MJ/day diet.) Mazindol caused a rise of hydroxyacyl CoA dehydrogenase in striated muscle by 70 per cent and a marked decline in malic dehydrogenase. Mazindol also produced higher levels of non-esterified fatty acids--significantly higher during the fifth starvation period; a small decrease in blood glucose, IRI and glucose/IRI ratio being unaffected, a significantly two-fold greater decrease of serum cholesterol; a significant increase of the noradrenaline elimination compared with a decrease in controls and in increase in triiodothyronine binding globulin towards the upper range of normal.
Partial trisomy for the short arm of chromosome 2 due to familial balance translocation.
A partial trisomy for the short arm of chromosome 2 (p21 leads to pter) was observed in a severely retarded infant with facial, skeletal, genital, renal, and CNS anomalies. The phenotypically normal mother and older brother had a balanced translocation between the short arm of chromosome 2 and the long arm of chromosome 14: 46, XX-XY,t(2;14)(p21;q32).
[The effect of strict weight-reduction regimen on nucleic acid contents in obese persons' skeletal muscles (author's transl)].
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[Energy metabolism enzymes in obese women--relationships to the incidence of obesity in antecedence (author's transl)].
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Some recent findings in obesity.
The tendency of some obese subjects to an energy-sparing reaction can be induced temporarily by attempts of the patient to reduce his overweight by prolonged starvation. This regulatory reaction may be induced by regulatory especially thyroid mechanisms. In obesity of both sexes a tendency to anaerobic energy utilization in the muscle can be revealed and so a tendency to decrease energy utilization in general. The differences in insulinemia (IRI) displayed a prevalence of maternal obesity in the group with higher levels of basal and stimulated IRI values, which decline after changes in diet and body weight. This behavior of IRI levels and amount and composition of diet indicate a possible permissive role of previous food consumption habits.
[Effects of mazindol on some parameters of energy metabolism regulation in weight reduction of obese subjects (author's transl)].
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Obesity and thyroid function. 3. Relationship between some indicators of thyroid function and the energy metabolism of striated muscle in obese women.
1. In a group of 23 obese women the relations between some indicators of thyroid function (thyroxine-binding globuline--T4BG, triiodothyronine-binding globuline--T3BG, Achilles tendon reflex--ART) on the one hand and activities of enzymes of the energy metabolism (hexokinase--HK, triose phosphate dehydrogenase--TPDH, lactate dehydrogenase--LDH, glycerol-3-phosphate dehydrogenase--GPDH, citrate synthease--CS, malate dehydrogenase--MDH, hydroxyacyl--COA dehydrogenase) in the quadriceps femoris muscle on the other hand were investigated. 2. Correlations were found between T4BG and TPDH, LDH and GPDH activities, between T3BG and TPDH and GPDH activities and between the value of the Achilles tendon reflex and TPDH activity. Functionally these enzymes activities are associated with glycolysis and hydrogen transport from cytoplasmatic NADH2. No correlations were found between enzymes of the aerobic metabolism incl. enzymes of fatty acid oxidation and indicators of thyroid function. 3. The results indicate a relationship between thyroid function and enzymes involved in glycolysis and hydrogen transport from cytoplasmatic NADH2. They do not suggest, however, the unequivocal conclusion that in obese women with reduced thyroid function there is a generally reduced energy supplying metabolism in skeletal muscle.
[Calcium balance in obese women during total starvation (author's transl)].
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[Influence of calcium loss in total starvation in obese women (author's transl)].
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[On the problem of human adipose tissue hyperplasia and hypertrophy (author's transl)].
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