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Biomedical subjects

R R Smith

Publications and source records attributed to R R Smith.

At least 163 records · Page 9Linked to original sources
PubMed1981

Incidental pituitary adenomas.

Pituitary glands from 500 consecutive autopsies were reviewed and the findings correlated with clinical symptomatology. Occult pituitary adenomas were identified in 42 pituitary glands (8.5%). In only one case was a pituitary lesion clinically questioned, but specific hypophyseal function studies were not performed. These tumors occurred most frequently in the sixth and seventh decade of life, without obvious sex predominance. Of these patients, 48% were obese, 57% were hypertensive, and diabetes mellitus was noted in 11. The tumor size ranged from 1 to 15 mm, but was greater than 1 cm in only one case. In 34 cases, the tumor was located along the periphery of the gland. Even though the etiological and functional significance of these tumors is unclear, the clinical course appears to be relatively benign.

Adenoma↗
PubMed1980

Bilateral traumatic facial paralysis.

Bilateral, post-traumatic, peripheral 7th cranial nerve palsies were observed in three patients, two of whom were studied carefully with tomography and audiological examination. All of the patients recovered their motor function spontaneously.

Adolescent↗
PubMed1980

Ultrastructure of carotid plaques.

Scanning electron microscopic evaluation of the resected plaques from 11 patients with symptomatic and asymptomatic lesions of the carotid artery bifurcation were carried out. The most common findings were mounds of atheromatous material, many of which appeared to be fractured and capped with fibrin-platelet exudates, projecting into the lumen of the vessels. Both small and large ulcer craters were identified, and attached bodies were present in three-fourths of the specimens studied. These consisted most commonly of platelet clumps and fibrin sheets and were intimately related to the atheroma.

Carotid Arteries↗
PubMed1979

Adenomatoid odontogenic tumor: ultrastructural demonstration of two cell types and amyloid.

A typical adenomatoid odontogenic tumor removed from a 13-year-old female was studied by light and electron microscopy. The tumor was composed of two types of epithelial cells: Type I cells were cuboidal and occurred in nests or formed ductlike structures and Type II cells were smaller and spindle shaped. The formation of extracellular masses of amyloid was found in association with Type I epithelial cells, and amyloid formation was not observed in association with Type II cells. Results suggest that the lesion is of enamel organ origin, derived from cells of the inner enamel epithelium at the pre-ameloblastic stage, stellate reticulum and stratum intermedium. The origin of this amyloid material is unknown; however, it may be of enamel protein origin which, like amyloid, may have a beta-protein conformation.

Adolescent↗
PubMed1979

Ischemic heart disease secondary to amyloidosis of intramyocardial arteries.

Among 108 patients with cardiac amyloidosis studied at autopsy between 1889 and 1977 there were 5 (4.6 percent) with severe occlusive amyloid deposits in intramyocardial arteries. The hearts of all five patients showed focal subendocardial ischemic injury, and the vessels supplying these areas had either complete or near complete luminal obliteration by amyloid. Clinically, four patients had congestive heart failure; one of these patients also had arrhythmias and one had angina pectoris. Neither the clinical nor the pathologic features of ischemic heart diseases could be attributed to disease of the epicardial coronary arteries. Amyloidosis of the intramyocardial arteries appears to be capable of producing localized areas of ischemic necrosis and may produce intractable congestive heart failure due to multiple areas of ischemic injury.

Aged↗
PubMed1978

Heat increment associated with dietary protein, fat, carbohydrate and complete diets in salmonids: comparative energetic efficiency.

The heat increment (HI) of feeding, which is the increased heat production following consumption of food by an animal, accounts for as much as 30% of the ingested metabolizable energy (ME) in mammals and birds. The purpose of these experiments was to measure the HI associated with the feeding of a complete diet and purified fat, protein, and carbohydrate to salmonids. Measured amounts were fed and the heat production was measured by direct calorimetry. Increased heat production was observed about 30 minutes after feeding and remained elevated for 1 to 5 hours, depending on the amount and type of material fed. The HI of protein was much lower with fish than with mammals and amounted to less than 5% of the ingested ME. The HI's of carbohydrate and protein were not significantly different from each other but both were higher than fat. The HI, when complete diets were fed, was less than 3% of the ME. The net energy of protein is higher for fish than for birds or mammals. A major part of the superior energetic efficiency of fish is due to the low energy cost of protein metabolism.

Animals↗
PubMed1978

A flap suspension technique in blepharoplasty on lower lids.

Blepharoplasty on lower lids frequently results in a downward pull on the free border of the lid and inferomedially on the lateral canthus. Extending the incision in the lower lid upward and lateral to the outer canthus allows most of the excision to occur laterally. Closure then pulls superolaterally, which tends to prevent the commonest complications of blepharoplasty on lower lids.

Adult↗
PubMed1977

Carcinoma in situ of the breast.

A series of 87 cases of carcinoma in situ of the breast was reviewed. IN 49 CASes in which lobular carcinoma in situ was shown on biopsy, three patients were found to have invasive carcinoma in the subsequently done mastectomy. All three of these cases were in a group of 14 patients shown in have bilateral lobular carcinoma in situ on biopsy. In a group of 38 patients with intraductal carcinoma on biopsy, seven were found to have invasive carcinoma in the mastectomy that was subsequently done. Lymph node metastases were found in one patient in the lobular group and four patients in the intraductal group. Three patients in the intraductal group died of cancer. None in the lobular group has died of cancer.

Breast Neoplasms↗
PubMed1976

Arteriovenous malformation of the vein of Galen: treatment in a neonate.

Heart failure in a 2-day-old infant was not readily explained by clinical examination. Cardiac catheterization suggested an intracranial arteriovenous (AV) fistula, and cerebral arteriography showed a malformation of the vein of Galen. The major feeding arteries were surgically obliterated. At age 27 months, the boy has normal mentation but moderate left hemiparesis. Review of the literature disclosed 39 other infants with AV malformations of the vein of Galen producing heart failure before age 3 months. Most of them were boys, and had cyanosis, a systolic murmer, cranial bruit, cardiomegaly, and right bentricular hypertrophy. Only three of the 13 who had surgery for their malformation survived. Removal of the malformation is difficult; obliteration of the nutrient vessels, using the operating microscope, is the currently accepted treatment.

Angiography↗