Thirty-one cases of a new hereditary chondrodystrophy in the rabbit have been shown to be associated with a fully penetrant autosomal recessive gene symbolized cd. The mutant is viable prenatally but does not survive after birth. It differs from the two other inherited chondrodystrophies, dachs and achondroplasia, but is very similar to the metatropic dwarf reported in man.

Animals↗

PubMedDate not supplied

Identical genetic basis for lymphosarcoma and hemolytic anemia in the rabbit.

Tests for identity of ha (hemolytic anemia) and ls (lymphosarcoma) in the rabbit show that they are both allelic and identical by descent and that the two different conditions result from interaction of these genes with the host genotype. Hemolytic anemia is the primary cause of death in compound heterozygotes (ha/ls) with increasing lympho-proliferative disease with age. Ages at death of histologically confirmed affected rabbits range from 5 days to 22.5 monts with an average of 10.5 months. The symbol ha will now be used to represent the gene for either disorder.

Alleles↗

PubMedDate not supplied

Clinical hematological progression of hereditary lymphosarcoma in rabbits.

Considerable diversity exists in the clinical progression data for lymphosarcoma both between and within species. Thirty-four rabbits with hereditary lymphosarcoma were used to define the clinical progression of this condition under controlled genetic conditions. Changes in the erythropoietic cells of the rabbit hemogram in cases of hereditary lymphosarcoma (ha/ha) follow a fairly well defined clinical course of about one-and-one-half months duration. Data are presented showing that these changes are subsequent to schanges in the granulocytic cells of the leukocyte series both peripherally and in the bone marrow.

Animals↗

PubMedDate not supplied

Effect of ascorbic acid on intraocular pressure of normal and buphthalmic rabbits.

Compared with serum the aqueous humor of the eye is high in ascorbic acid. The administation of ascorbic acid appears to have a transient hypotonic effect on intraocular pressure in normal eyes. Its effect on glaucomatous eyes is not as well defined particularly in the case of the rabbit. In this communication we shown the ocular hypotensive effal (+/+) or have hereditary glaucoma (bu/bu). We also show that the transport of ascorbate from the serum to the aqueous is much slower in buphthalamic rabbits than in normal controls. Osmolarity is suggested as a possible hypotensive mechanism and a differential fluid transport rate between the blood and the aqueous for the different genotypes is suggested as a possible mechanism for the difference in duration.

Animals↗

PubMedDate not supplied

Strain differences in the prealbumin serum esterases of JAX rabbits.

The serum prealbumin esterase phenotypes were determined for 431 adult rabbits representing the majority of the breeding stock of the genetically defined JAX rabbits. Uniform phenotypes were observed in 8 of the 15 strains where adequate samples were obtained. In all of the phenotypes where uniformity was observed, the Est-2F gene was lacking. Also, all 431 rabbits lacked the Est-3D allele commonly observed in Europe. A sex difference was seen in the f' zone, which was darker in females than in males when the staining process was twice the normal length of time.

Animals↗