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Biomedical subjects

R R Crowe

Publications and source records attributed to R R Crowe.

97 records · Page 6Linked to original sources
PubMedDate not supplied

The utility of the Brief MAST' and the CAGE' in identifying alcohol problems: results from national high-risk and community samples.

BACKGROUND: The CAGE and the Brief MAST questionnaires are widely used to screen for alcohol problems. We tested the performance of these instruments in 2 population-based groups: a high-risk sample composed of relatives of alcoholic subjects and a community sample consisting of families not selected for alcoholism (ie, alcohol dependence disorder). METHODS: A total of 3435 relatives of alcoholics and 795 control subjects were interviewed with the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) semistructured interview in a multicenter collaborative study on the genetics of alcoholism. The performance of "CAGE" and "Brief MAST" equivalent items in the SSAGA was characterized by their positive predictive value, sensitivity, specificity, and percentage of the sample who screened positive. RESULTS: Both questionnaires performed well in the highrisk sample, where the base rate of alcoholism was 35%. However, in the community sample, where the 16% rate of alcoholism was comparable to that of the US population (14%), an acceptable positive predictive value could be achieved only through a substantial reduction in sensitivity. Results were similar when men were compared with women and when lifetime alcoholics were compared with current alcoholics. CONCLUSION: The "Brief MAST" and "CAGE" can be effective instruments to screen for significant alcohol problems in both community and high-risk patients; as expected, their positive predictive value increases with the base rate of alcoholism in the population being screened.

Alcoholism↗
PubMedDate not supplied

A family study of anorexia nervosa and bulimia.

A family study is presented that examines the association between eating disorders and affective illness. 307 relatives of 30 eating disorder patients, of 16 patients with major depression, and of 20 normal controls, were interviewed to determine lifetime histories of psychiatric illness. Using logistic regression analyses, the results supported previous findings of a familial association between eating disorders and major depression. However, there was no evidence that clinical features of eating disorder patients (presence of bulimia or major depression) can be used to predict morbid risk. In addition, the results failed to reveal a familial aggregation of either alcoholism or drug abuse in eating disorder families.

Adult↗