[Life expectancy in diabetes mellitus].
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Biomedical subjects
Publications and source records attributed to R Petzoldt.
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Blood glucose and serum insulin values were determined after oral glucose tolerance tests in 528 persons with suspected pathological or disturbed glucose tolerance. Results were evaluated depending on sex, age, overweight, and familial diabetes. There were no differences of serum insulin secretion and behaviour of blood sugar between males and females. With increasing age there was a marked decrease of insulin secretion. In contrast there was increased hyperinsulinaemia with increasing overweight. This was particularly evident in persons with comparably reduced glucose tolerance but with different body weight. "Classical" changes of insulin secretion, as described for prediabetes and manifest diabetes in contrast to persons with normal metabolism, were only seen in selected groups of probands with normal weight. Serum insulin shows greater variability than blood glucose. Estimations of insulin are not necessary when assessing disturbances of glucose tolerance.
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The localisation of arteries or veins is facilitated by the use of an ultrasound Doppler unit. This method has proved particularly valuable when dealing with deep lying vessels which are neither visible nor palpable. Until recently, such vessels had to be punctured blindly. This technique employs the Doppler ultrasound-method, which is especially used in the diagnosis of diseases of the peripheral vessels. There also not only useful for the localisation but able to assist the puncture of the vessel.
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Ultrasound B-scan (real time and gray scale technique) has proved to be a noninvasive, low expensive and suitable method in internal tumor diagnostics. The most important fields are the diagnosis of pancreatic tumors, of malignant lymphomas, of tumors of the kidneys and the adrenal gland. Furthermore there is possible the diagnosis of tumors of the liver, the bile ducts, the spleen and the thyroid gland. The differentiation between solid and cystic tumors has shown to be a domain of ultrasonography. The limitations of the method are caused by the relatively bad (lateral) resolution of ultrasonography. Therefore tumors smaller than 1.5 cm cannot be diagnosed regularly. There is, moreover, no ultrasonic pattern typical of malignancy.
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The benefits of professional advice on dietetics in the medical practice can, at present, not be measured directly. They can only be assessed indirectly on a model basis using drugs savings as the benefit's indicator. If for example those some 880,000 diabetics of the Federal Republic of Germany who are treated with oral antidiabetic drugs and suffer from overweight would lose weight as a consequence of dietetic consultation, they could save at least 1 pill per day of a blood glucose lowering sulfonamide or biguanide derivate. This equals about 131 million DM p.a. If only 10 percent of 1000 diabetics under the advice of one assistant dietician would lose weight--in about 20 percent of all dietetic consultations such a success can be expected--this would cover the cost of such consultation.--In fact, in a sample of 228 diabetics with overweight, who received intensive advice on weight reduction, 85 percent were successful in losing weight, improved their metabolism, and therefore needed less antidiabetic drugs. They thus achieved annual cost savings about equal to an assistent dietician's salary. Thus, the employment of assistant dieticians in the medical practice is an advantage also from the economic point of view, and should be made possible for all practitioners interested.
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Two dimensional B-Scans make it possible to examine and measure the spleen. In 62 patients the size of the spleen was evaluated by ultrasound; the results were compared with the size of the organ after extirpation: In 58 of 62 cases there were correct results. Therefore, the ultrasonic determination of the splenic size is a reliable method for clinical questions.
Chronic lymphocytic leukemia was diagnosed in three siblings. Familiar occurrence speaks in favor of a predisposition in this disorder of unknown etiology. According to the present status of knowledge endogenous - genetically determined - factors combined with exogenous factors (viruses, radiation exposure, toxic substances) participate in the etiopathogenesis of the different forms of leukemia.