Biomedical subjects
Publications and source records attributed to R Panizzon.
A clinico-pathologic study on 12 patients with subungual malignant melanoma (SUM) is presented and cases from the literature are reviewed. The difficult diagnosis of SUM as well as the differential diagnosis is discussed. The SUM sometimes called "melanotic whitlow", is often misdiagnosed and therefore may worsen the prognosis. Every persistent nail disorder which does not respond to treatment should rise suspicion of SUM, especially if not pigmented.
In a 31-year-old patient with a basal cell nevus syndrome two basal cell epitheliomas occurred through exogenous factors. The tumors appeared within 18 years after BCG vaccination and 3 years after an intravenous drip respectively. In basal cell nevus syndrome this course of development of basal cell carcinomas is seldom described.
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Osteopoikilosis (Osteopathia condensans disseminata) is a rare and usually asymptomatic sclerosing bone dysplasia of unknown origin. Familial clustering suggests a dominant inheritance. The observation of a 47-year-old woman lead to differential diagnostic considerations in view of the literature on about 350 cases. For 2 years the patient has been complaining about pain and stiffness of both hands with swelling of the fingers. Additionally, she remarked about bilateral paresthesias corresponding to the sensory innervation of the median nerve. Clinical examination revealed a sensory carpal tunnel syndrome and mild synovitis of the proximal interphalangeal joints with skin induration and limited flexion of the fingers. In addition, some finger and toe nails showed pitting and most fingers had scar-like linear skin alterations. Radiologic findings showed symmetric, well-defined, homogeneous sclerosing areas in spongy bone. The combination of symmetrical sclerosing bone densities, hereditary character, and associated skin and joint manifestations suggests the existence of a general connective tissue disease.