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Biomedical subjects

R Panizzon

Publications and source records attributed to R Panizzon.

At least 55 records · Page 3Linked to original sources
PubMed1988

Familial Becker's nevus.

The authors describe 4 patients with Becker's nevus (BN) in two families. Another 4 patients of the german literature are also presented. Together with the first two published cases of BN, familial BN is now known in 10 patients. All three clinical types of BN could be noticed.

Adolescent↗
PubMed1987

[Syringoma of the vulva].

A case of a 20-year-old white female patient is presented, who developed syringomas on the labia majora. The 12 cases that have previously been described in the literature are summarized. Syringomas should be considered in the differential diagnosis of papular lesions of the vulva and are probably more common than is reflected in the number of cases published.

Adenoma↗
PubMed1986

[Radiotherapy of malignant melanoma of the skin--a renaissance?].

Surgery is without question the treatment of choice for the malignant melanoma (MM) of the skin. Radiotherapy, on the other hand, has been more and more neglected, especially because of the opinion that melanomas are "radioresistant". Because there is an increasing interest in the radiotherapy of MM in the recent years, and reviewing the experimental and clinical findings in the literature the following points are made: MM is not a "radioresistant" tumour and therefore the expression reduced radiosensitivity should be used instead; radiotherapy with beams of low linear energy transfer (LET) is also possible if the techniques involve the use of high dose per fraction or multiple fractions per day; different types of MM of the skin show a variable radiosensitivity in vitro and in vivo; and indications still exist for the radiotherapy of MM. All possibilities for the use of radiotherapy alone in MM have not yet been exhausted.

Cell Survival↗
PubMed1984

Soft X-irradiation influences the integrity of Langerhans cells. A histochemical and immunohistological study.

This report defines the influence of field soft X-ray irradiation on the integrity of epidermal Langerhans cells (LC) in the guinea pig and mouse systems. Male albino (Rockefeller strain) and piebald F 1 (2 X 13 strain) guinea pigs as well as C3H mice (H-2Kk) were exposed to one single shot of different dosages of soft X-rays [80, 1,200, 1,600, and 3,200 R; 30 kV, 0.5 mm aluminium filter, FSD (focus-skin distance) 12 cm]. 1 and 4 weeks after exposure, skin specimens were taken from the irradiated skin. The demonstration and evaluation of LC was performed basing on their expression of specific histochemical (ATPase) and functional immunologic markers (Ia antigens). Soft X-irradiation had pronounced effects on number and structure of ATPase- and Ia-antigen-positive cells. In the mouse system, 1 week after exposure to 800 and 1,200 R ATPase-positive cells and, in a more or less parellel manner, Ia-antigen-positive cells () were reduced to 74% (74%) and 70% (68%), respectively, and 4 weeks after exposure to 49% (47%) and 43% (40%), respectively. In the guinea pig system one single shot of 1,600 or 3,200 R produced, respectively, a 35% or a 38% reduction of ATPase-positive cells. Prolonged survival did not result in a further depletion of ATPase-positive cells.

Adenosine Triphosphatases↗
PubMed1984

The nails in keratosis lichenoides chronica. Characteristics and response to treatment.

Keratosis lichenoides chronica may be seen clinically and histologically as a variant of lichen planus. One in three patients have nail involvement with changes that may superficially resemble psoriasis, but pitting and pustulosis do not occur. Hyperkeratotic hypertrophy of the periungual tissues is a distinctive feature. Psoralens and UV-A therapy as well as etretinate have improved some cases.

Etretinate↗
PubMed1984

[Becker nevus. A clinico-histologic-electron microscopy study of 39 patients].

The study presented here is based on the clinicopathological and electron microscopical analysis of 39 patients with Becker's nevus (BN). The clinical picture is variable and we therefore suggest the following three types be distinguished: (1) the melanotic type, (2) the hypertrichotic type, and (3) the mixed type. In BN the sensitivity reaction was often diminished. Among the skin eruptions other than BN, we would like to stress that 12% of our patients showed a malignant melanoma. Histopathology concerns both epidermal and dermal structures. The electron microscopic findings corresponded well with those by light microscopy. As far as we know, the changes in collagen fibrils are demonstrated for the first time in this study.

Adult↗
PubMed1982

[Acral-lentiginous melanoma: the newest subgroup of malignant melanomas of the skin].

A new subgroup of malignant melanoma, acral-lentiginous melanoma (ALM), is presented, which the authors have diagnosed in 8% of their melanoma patients. In a retrospective study the clinical and pathological findings in 44 patients with ALM are reviewed. A relationship was found between age, tumor diameter and thickness, pigmentation, ulceration, vasoinvasion and mitoses. The author's patients had a 5-year survival rate of 58%.

Adult↗
PubMed1982

Hyperpigmented small spots induced by long-term PUVA therapy. A clinical, light and electron microscopic study.

Among 308 photochemotherapy (PUVA)-treated patients, 15 psoriatics and 1 case of mycosis fungoides developed persistent disseminated hyperpigmented small spots at the trunk and limbs as a side effect of the therapy. The histological, histochemical and electron microscopical studies performed on 5 of the patients revealed a greatly increased number of melanocytes in the macules, hyperactivity of the melanocytes and increased transfer of pigment to dermis and keratinocytes. Moreover, binucleated cells were found as well as multifarious signs of melanocytic damage in varying degrees. Similar alterations but less pronounced were observed in the intermacular skin. Some of the changes could be recognized even 7 months after the treatment had been stopped. The PUVA spots are compared with other etiologically light-dependent hyperpigmentations.

Adult↗
PubMed1982

Histopathology of pityriasis rosea Gibert. Qualitative and quantitative light-microscopic study of 62 biopsies of 40 patients.

62 biopsies of 40 patients with pityriasis rosea Gibert (PRG) were analyzed qualitatively and quantitatively. The main histopathological feature is eczematoid. In addition, the following characteristics, especially in combination, are helpful for the differential diagnosis: absence or decrease of the granular cell layer, erythrocytes in the papillary dermis and partly in the epidermis, and homogenization of the collagen of the papillary dermis. Recent and older lesions show little difference although the number of eosinophils in the inflammatory infiltrates has generally increased.

Biopsy↗
PubMed1981

[Pigment spot polyposis (Peutz-Jeghers syndrome)].

Clinical findings in Peutz-Jeghers-Syndrome in a 14-year-old female patient are presented. In addition differential diagnosis and therapeutic possibilities are discussed. Furthermore, the authors assume that ultrastructural characteristics of this pigment disorder are described for the first time.

Adolescent↗