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Biomedical subjects

R Padovani

Publications and source records attributed to R Padovani.

At least 73 records · Page 4Linked to original sources
PubMed1986

Skeletal muscle changes following myelotomy in paraplegic patients.

Pourpre's dorsal T-shaped myelotomy was performed on three paraplegic patients in which medical and electro-physiological procedures proved to be ineffective concerning muscle spasms. The myelotomy led to the elimination of spasms and of muscle hypertonicity in the lower limbs. Biopsies of the rectus femoris muscles were performed bilaterally one year before and two months following myelotomy. The first biopsy revealed fascicular atrophy, with type I fibre preferential atrophy, which is usually found in paraplegic patients. After myelotomy some histological differences were seen: reduction of type II fibre diameter and the presence of target-targetoid fibres and of atrophic dark fibres. There was a difference of fibre pattern type in hypertonic spastic muscles compared to that seen in spasm relieved by myelotomy. The morphological changes seen after myelotomy are interpreted as denervation changes because of the surgical lesion by the myelotomy on the anterior horn cells.

Adult↗
PubMed1986

Platelet-derived growth factor(s) mitogenic activity in patients with myeloproliferative disease.

Platelet-derived growth factor has been invoked in the pathogenesis of medullary fibrosis during myeloproliferative disorders. In this study we compared the mitogenic activity of heat-stable platelet-growth factor(s) from 13 patients suffering from myeloproliferative disorders with that of a normal group. The test was carried out on Go growth arrested Balb/c 3T3 fibroblasts incubated with various concentrations of platelet extracts, determining the entrance into the S phase by means of [14C]thymidine uptake. The incorporation curves of [14C]thymidine by the fibroblast culture, under the effect of pathological extracts, were consistently lower than the control curve, indicating a lower level of PDGF(s) in platelets from patients. The greatest depression of this activity was found to be associated with highest degree of medullary fibrosis (agnogenic myeloid metaplasia patient group), in agreement with the hypothesis that fibroblast activation within bone marrow during myeloproliferative disorders might be correlated with a PDGF(s) release in the bone marrow environment.

Adult↗
PubMed1985

"Pure" traumatic cerebral lacerations. A review of 129 cases with long-term follow-up.

The authors present a series of 129 patients with "pure" traumatic cerebral lacerations, i.e. not associated with other intracranial lesions (especially haematomas) which by their presence alone can play a primary role in affecting clinical course and prognosis. Twenty per cent of the patients presented a lucid interval, thus confirming the nature of the laceration as a true expanding lesion, increasing in size in the post-traumatic period. Age, GCS score and neuroradiological findings were investigated in view of the eventual outcome. Follow-up examination confirmed that age and level of coma on admission, together with the degree of ventricular shift and presence of bilateral skull fractures, were all factors of statistical significance in affecting prognosis. Lacerations in the temporal area were associated with the poorest prognosis, and highest incidence of neurological focal deficits and residual parenchymal damage on CT control.

Adolescent↗
PubMed1984

Response of thermoluminescence dosemeters to beta radiation and skin dose assessment.

The response of a TL dosemeter to beta radiation is heavily influenced by the absorption of the radiation in the dosemeter thickness. As a consequence, the assessment of skin dose depends either on the execution of a calibration with a beta field of the same characteristics as that to be monitored or on the knowledge of depth-dose distribution in the dosemeter. Depth-dose distributions have been experimentally estimated for optically transparent dosemeters in a number of irradiation geometries and with sources of different configuration and energy. General algorithms based on the point-source function of Loevinger have been developed, by which the response of TL dosemeters can be evaluated and skin dose correction factors derived. TLD responses to beta radiation calculated by the present method are in sound agreement with other author's measurements. The dependence of beta ray absorption on the configuration of source and the source-to-detector distance has been picked up. Variations of source-to-detector distance as large as 30% of the maximum beta range account for differences up to 40% in the skin dose correction factors for a 200 mg cm-2 thick dosemeter. The proposed scheme results in a useful tool in skin beta dosimetry using multiple TLDs behind different absorbers. In practical applications thick dosemeters may be used properly only in well-known radiation fields. Conversely, the described method allows an acceptable estimate of the skin dose error.

Electrons↗
PubMed1983

[Basic therapy of rheumatoid arthritis with thiopronine. Preliminary results].

A long term open study of the use of thiopronine in the treatment of 38 patients with ARA classified "classic" or "definite" rheumatoid arthritis is reported. Doses of the drug were increased from an initial 250 mg per diem by the addition of 250 mg every 15 days to 1 g per diem. After 6 months testing, results were satisfactory (good and fair) in 65% of the cases in both biological and clinical terms. In 15% of the cases, treatment was interrupted mainly due to mucous and cutaneous side effects. These preliminary results confirm reports in the literature and encourage further experiment.

Administration, Oral↗
PubMed1983

Association of cerebral mycotic aneurysm and brain abscess.

The authors report a case of brain abscess which occurred as a possible complication of a mycotic aneurysm. Inadequate antibiotic treatment given at the time of a febrile illness in a patient with rheumatic heart disease seems to be the most likely cause of this unusual complication. The effects of inadequate antibiotic treatment on the pathogenesis are briefly discussed.

Adult↗
PubMed1983

Dependence of the linear model for the nerve compound action potential on the single fibre action potential waveform.

The linear model of the nerve compound action potential (CAP) depends on the assumed waveform for the single fibre action potential (SFAP). A general method has been developed to investigate the influence of the unknown features of the SFAP on the estimation of nerve fibre conduction velocity (CV) distribution. A SFAP waveform is considered consistent with the model and the experimental data if recorded and reconstructed CAPS fit and the distribution is physically meaningful. Experimental CAPS were monopolarly recorded using surface electrodes over the median nerve at the wrist. To fit the model, SFAP waveforms must satisfy some internal relationship. The most important feature is that the ratio between positive and negative areas of the SFAP is almost one and does not vary in different subjects and recording sites. Many SFAP waveforms fit the model, and the relative conduction velocity distributions may be very different. These must be regarded as conventional distributions. As for inter-subject comparison, the dependence of the method on the recording site has been reduced by choosing the place where stimulus intensity and relative motor response amplitude have given values. In this recording environment CV distributions of normal subjects can be properly compared using the same SFAP and deviations from normality evidenced.

Action Potentials↗
PubMed1983

Teratoid cyst of the spinal cord.

The authors report a rare case of intramedullary teratoid cyst, in which an arteriovenous malformation of the spinal cord was first suspected. The controversial problem of the histogenesis of teratomas is reviewed. The authors stress the benign course of these lesions after operation, even when radical surgery cannot be performed.

Adult↗
PubMed1983

Leptomeningeal angiomatosis and aplasia congenita of the scalp. Case report.

This 9-year-old boy had two circular areas of aplasia congenita of the scalp in the territory of the first division of the trigeminal nerve and an ipsilateral parieto-occipital leptomeningeal capillary venous angioma. He had an associated giant aneurysm of the distal posterior cerebral artery on the same side as the vascular malformation. The patient had a long history of seizures and presented with intracerebral bleeding. This case may be considered as a variant of Sturge-Weber syndrome. Further observations must be added to consider this entity as a separate neurocutaneous disease.

Angiomatosis↗
PubMed1983

[Multivariate statistical analysis in predicting bronchopulmonary complications after surgical interventions in cancer of the lung].

A multivaried statistic process, the linear discriminant analysis, applied to VEMS, CV, I.T., FEF 25-75, pH, PaO2, PaCO2, was used by the authors to foresee, in 42 patients suffering from bronchogenous carcinoma, the arising or absence of respiratory complications after operation. With such method, the falsely positive or negative previsions, resulted to be 13 with a total percentage of error as high as 30%. These results suggest that, even when elaborated through the multivaried analysis, the parameters studied do not allow to adequately discriminate the patients who would develop, after operation, bronchopulmonary complications from those who would be exent from them.

Adult↗
PubMed1982

Immunological monitoring of patients affected by anaplastic glioma concerning in effects of surgery, radio-, and chemotherapy. A preliminary report.

The authors studied 24 patients affected by anaplastic gliomas, as regards immunology. In all of them the authors evaluated the lymphocyte subpopulation (B and T), firstly by simple lymphocyte count, secondly by studying the rosettes E-total and EAC, thirdly by stimulating the lymphocytes with mitogens phyto-haemoagglutinin-P (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM), and lastly by counting the release of Cr51 in Chang liver cells culture in order to obtain antibody dependent cellular cytotoxicity (ADCC). The parameters were also evaluated after surgery and during conventional radio-chemotherapy with BCNU. Whereas the so-called B-pool seems to be unaffected, the preliminary results show that the T-pool (identified by the E-t rosettes and by responses to PHA, PWM, and ConA) is depressed to a statistically significant degree, if compared with a control group. This depression seems to be related to the tumoral mass, and it is not increased by radio-chemotherapy. In addition, ADCC also seems to be depressed in our glioma patients in comparison with a control group and witha group of bladder cancer patients.

Adult↗
PubMed1982

Extrathecal cavernous hemangioma.

A case of extrathecal cavernous hemangioma, a rare entity, is presented. Some clinical, radiological, and histological features of the lesion are discussed. The unusual dumbbell-like growth of the tumor through an intervertebral foramen is considered, as well as the potential effectiveness of radiation therapy. The literature dealing with spinal hemangiomas and hemangioblastomas is summarized.

Aged↗
PubMed1982

Spinal extrathecal hemangiolipomas: report of two cases and review of the literature.

Two cases of a rare entity, spinal extrathecal hemangiolipoma, are presented. The clinical and histological features of the tumor are discussed, with particular attention to the uncommonly sudden onset of symptoms in one patient. Complete neurological recovery was exhibited by one patient after excision of the lesion, whereas only a partial recovery was achieved in the other case. The pathogenetic aspects of hemangiolipomas and the literature dealing with the previously reported 12 cases are reviewed.

Hemangioma↗