The incorporation of 3H-leucine into protein from anterior and posterior cerebellum, cerebral cortex and liver was studied in rats given 50% of calories as ethanol, brandy, whisky, gin, red wine or isocaloric amounts of glucose together with diets with moderate or low protein-vitamin content for 8--9 months. Higher incorporation rates were usually observed with higher protein-vitamin administration. Red wine and brandy rats usually had the highest, ethanol and gin rats usually the lowest incorporation rates. The incorporation rate thus increased with amount of congeners present.

Alcoholic Beverages↗

PubMed1978

Determination of fast-acting plasmin inhibitor (alpha2-antiplasmin) in plasma from patients with tendency to thrombosis and increased fibrinolysis.

The physiologically important alpha2-antiplasmin has been measured by aid of a chromogenic tripepetide substrate. Low values in patients' plasmas are found in situations with increased fibrinolysis such as streptokinase therapy and liver cirrhosis, whereas high values are found postoperatively, postpartum and after an acute thrombosis.

Acute Disease↗

PubMed1978

Changes in "routine laboratory tests" during abstinence after heavy alcohol consumption in chronic alcoholics.

Standard laboratory tests were studied in 61 male chronic alcoholics admitted for detoxication after a period of heavy alcohol consumption. Results obtained within three days after the end of the last debauche were compared with those obtained one week later. Almost half of the patients was considered to have thrombocytopenia, two thirds of the patients had subnormal serum urea values and more than two thirds of the patients were considered to have increased ASAT values. Abnormal values often normalized within one week after admission. Significant alterations within the reference limits were observed for hemoglobin, erythrocyte sedimentation rate, sodium, potassium and bilirubin. The latter test often showed strikingly low values after one week. Most of the aberrations and the changes could be related to details in the case histories.

Alcoholism↗

PubMed1978

Elimination of paracetamol in chronic liver disease.

Serum concentrations of paracetamol were followed after oral administration of the drug to 21 patients with liver cirrhosis, 4 patients with secondary liver cancer, and 15 hospitalized patients without clinical evidence of liver disease. The cirrhotic patients had 50 per cent longer half-lives of the drug. They also had significantly higher values of AUC during the first 360 minutes, in spite of almost identical means values of Cmax and tCmax. Significant differences in paracetamol elimination between cirrhotics with and without ascites, or between cirrhotic with and without porto-caval shunt could not be demonstrated.

Acetaminophen↗

PubMed1977

Kinetics of intravenous administered L-phenylalanine in patients with cirrohosis of the liver.

The metabolism of intravenously administered L-phenylalanine has been studied in 13 patients with cirrhosis of the liver and in 17 control subjects. The decline in the plasma phenylalanine concentration followed a biexponential curve and the kinetics could be evaluated assuming a two-compartment model. The volume of the central compartment was reduced in the cirrhotic patients, reflecting a diminished liver pool size. The total phenylalanine clearance was lower in the cirrhotic patients, due mainly to a reduction of the liver cell mass or to changes in the intrahepatic membrane permeability and only to a minor extent to a reduced hepatic blood flow. The elimination rate constant from the central compartment was similar in both groups, suggesting that the remaining liver cells, had a normal capacity to hydroxylate phenylalanine to tyrosine. There was considerable overlapping in the kinetic parameters between the two groups, and even in patients with well established cirrhosis an apparently normal phenylalanine metabolism was observed.

Adult↗

PubMed1977

Serum lipids and lipoproteins during abstinence after heavy alcohol consumption in chronic alcoholics.

Serum lipids, liver function tests and liver histology were studied during a withdrawal period in sixty-one male chronic alcoholics with a well-documented earlier clinical history. In these alcoholics with a mean daily ethanol consumption of 340 g during the débauche, the FFA were initially high and decreased during the first week, concomitantly with an increase in serum triglycerides. 38% of the patients had a type IV hyperlipoproteinaemia with elevated serum triglycerides still after 17 days of abstinence. 51% were normolipidaemic at that time. The cholesterol content in the alpha-lipoproteins were initially elevated and normalized during the first week of abstinence. No relationships were observed between serum lipids and liver function tests or degree of liver steatosis or alcohol consumption. The present findings stress the importance of stating the duration of abstinence in studies of biochemical changes after withdrawal.

Adult↗

PubMed1977

The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.

The first plasma Factor II-VII-X value after admission to the hospital was higher than 90% in 29% of 38 common duct stone patients, in 9% of 33 patients with bile duct obstruction due to pancreatic carcinoma, and in 3 of 5 patients with cholestatic drug reaction. In contrast, the admission value was above 90% in only one of 89 patients with acute hepatitis and in none of 8 patients with a hepatocellular drug reaction. Therefore, a high plasma Factor II-VII-X activity in a patient with liver or biliary tract disease seems to be a rellained by an increased protein synthesis in the liver.

Acetaminophen↗

PubMed1977

Coagulation factors and other plasma proteins during abstinence after heavy alcohol consumption in chronic alcoholics.

Coagulation factors and other plasma proteins were studied in 19 male chronic alcoholics during the first abstinence week after a period of heavy alcohol consumption. In spite of a decade of chronic alcoholism and a daily alcohol consumption before admission of more than twice the 'normal' alcohol-metabolizing capacity, the data indicated a well-preserved protein-synthesizing capacity. In fact, the mean levels of some liver-synthesized proteins were above the upper reference limits. Minor changes within the reference ranges during the abstinence suggested a declining acute inflammatory reaction after cessation of intoxication.

Adult↗

PubMed1977

Hepatitis in secondary syphilis.

Explore the source record for details and available documents.

Adult↗

PubMed1976

Unusually high levels of blood alcohol?

A consecutive three-month study of alcohol-intoxicated patients admitted to the casualty ward showed 24 patients with an initial serum alcohol concentration above 110 millimols/liter. Eight patitents were excluded because of insufficient data. Eight of the remaining 16 patients showed surprisingly slight depression of the central nervous system (CNS).

Adult↗

PubMed1976

The follicular prolactin cells of the primitive teleost engraulis japonica.

The elopiform teleost Engraulis japonica was used for a light and electron microscopical study of the follicle epithelium in the rostral pars distalis of the pituitary. In this species, which has one large follicle in the anterior hypophysis, there is no persistent orohypophysial duct in postmetamorphic stages. The apical pole of the prolactin cells is almost completely overlaid by a surface layer of flattened epithelial cells with a thick glycocalyx. The prolactin cells reach the follicular lumen through "pores" in this cell layer and at the site of the pore the prolactin cells bear unusual specializations consisting of one cilium, several tall microvilli, and a mass of granular material. Prolactin release takes place at the basal pole of the cells.

Animals↗