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Biomedical subjects

R Olsson

Publications and source records attributed to R Olsson.

At least 145 records · Page 8Linked to original sources
PubMed1984

Hepatic dysfunction after open-heart surgery.

In a prospective study, 93 patients were observed up to nine months after open-heart surgery using hypothermia, hemodilution and cold cardioplegia. In the first two weeks frequent determinations were made of serum aminotransferase, alkaline phosphatases (ALP), lactic dehydrogenase isoenzymes, gamma glutamyltransferase (GT), total and free bilirubin and bile acids. Plasma hemoglobin was measured at the end of the operation. After the first period, aminotransferases, alkaline phosphatases and bilirubin were determined monthly. On the first postoperative day almost all of the patients showed abnormal aspartate aminotransferase (ASAT) activity and ASAT/ALAT (alanine aminotransferase) greater than 1, and about 25% had hyperbilirubinemia. The findings suggested early postoperative leakage of enzymes not only from the myocardium, but also from the liver. After two weeks the patients presented another pattern of liver dysfunction, with abnormal ALAT in 50%, ASAT/ALAT less than 1, and abnormal ALP and GT in 28 and 45%, respectively. Eight patients were judged to have post-transfusion hepatitis of non-A, non-B type. Six of them had abnormal aminotransferases for more than six months.

Alkaline Phosphatase↗
PubMed1984

Prevalence of markers of hepatotrophic viruses in alcoholics with symptomatic liver cirrhosis or pancreatitis.

The reason why similar amounts of alcohol consumption cause different types of organ damage in alcoholics is obscure. Recent studies indicate that hepatitis B virus infection may influence the development of liver cirrhosis in alcoholics. We investigated the prevalence of markers of viruses known to cause hepatitis (HAV, HBV, EBV, CMV) in two groups of patients, one with alcoholic pancreatitis without known liver cirrhosis and one with alcoholic liver cirrhosis without known pancreatitis. We found signs of past infection with HAV and HBV more often in alcoholics with liver cirrhosis than in patients with alcoholic pancreatitis or in age-matched controls.

Adult↗
PubMed1984

Incidence of liver disease in chronic lichen planus of the mouth.

Fifty-four patients with oral lichen planus were screened for chronic inflammatory liver disease utilizing standard biochemical parameters of liver function, serum levels of immunoglobulins G, A and M and circulating autoantibodies against mitochondriae, smooth muscle and cell nuclei. One patient had primary biliary cirrhosis, and another had cryptogenic cirrhosis. This study did not confirm previous observations of a frequent association of oral lichen planus and primary biliary cirrhosis or chronic active hepatitis.

Adult↗
PubMed1984

Alcohol consumption pattern and serum lipids in alcoholic cirrhosis and pancreatitis. A comparative study.

Drinking and dietary habits and serum lipids were studied in two groups of chronic alcoholics, one with liver cirrhosis and the other with acute or recurrent pancreatitis, with the intention of investigating whether these factors could be of importance for the seemingly haphazard occurrence of different organ damages in chronic alcoholics. Our data show that patients with alcoholic pancreatitis have a more intermittent drinking pattern than patients with alcoholic cirrhosis. The amount of alcohol required to cause pancreatitis seems to be smaller than what is necessary to produce cirrhosis. Although none of the cirrhotics had clinical symptoms of pancreatitis, 58% of the autopsied cirrhotics had some pancreatic damage at autopsy. It may be that symptomatic pancreatitis prevents the patients from drinking the larger amounts of alcohol necessary to produce cirrhosis. Dietary habits or occurrence of lipid abnormalities during abstinence did not differ between the groups.

Adult↗
PubMed1983

Opsin-immunoreactive outer segments in the pineal and parapineal organs of the lamprey (Lampetra fluviatilis), the eel (Anguilla anguilla), and the rainbow trout (Salmo gairdneri).

The pineal complex of Lampetra fluviatilis, Anguilla anguilla and Salmo gairdneri was studied by means of the indirect immunohistochemical antiopsin reaction. Opsin-immunoreactive material was demonstrated in the outer segments of the photoreceptor cells in the pineal organ of all three species investigated. In the lamprey, the opsin-positive outer segments were located in the lumen of the pineal vesicle and atrium. In the two teleost species, the immunoreactive outer segments were observed in abundance in the pineal end-vesicle and stalk. These structures were found to accumulate in the prominent initial portion of the pineal stalk of the eel. In the rainbow trout, immunoreactive outer segments occurred in the wide orifice of the pineal recess at the roof of the third ventricle. In addition, outer segments of photoreceptor cells of the parapineal organ ("parapinealocytes") displayed opsin immunoreactivity. In the lamprey, opsin immunoreactivity was restricted to the central portion of the ventral parapineal retina, while the parapinealocytes in the lateral portions did not bind the antibody. In the two teleosts, immunoreactive outer segments displayed a scattered pattern. These immunocytochemical results provide direct evidence that the photosensitivity of the pineal demonstrated electrophysiologically in lampreys and teleosts (cf. Dodt 1973) is based on an opsin-containing photopigment. The presence of opsin in cells of the parapineal organ strengthens the view that also this organ may be capable of direct light perception. In the lamprey, the exclusive opsin immunoreactivity of a circumscribed group of parapineal cells suggests the existence of two types of parapinealocytes. The significance of opsin-containing photoreceptor outer segments occurring in the most proximal portion of the teleost pineal stalk is discussed, especially with regard to the interpretation of results obtained from pinealectomy experiments.

Animals↗
PubMed1983

Hepatic reactions to cyclofenil.

Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed. The liver damage was probably related to metabolic idiosyncrasy, and was reversible in all patients.

Adult↗
PubMed1983

Chronic liver disease and autoantibodies to the Tamm-Horsfall protein.

Serum levels of immunoglobulin class specific antibodies to Tamm-Horsfall protein (TH) were studied in 25 patients with various liver diseases. Increased levels of TH-IgA antibodies were common in different types of liver disease, whereas high TH-IgM concentrations were observed only in patients with primary biliary cirrhosis or chronic active hepatitis. The occurrence of high concentrations of TH antibodies was not related to the occurrence of renal tubular acidosis detected by an acidification test, but the elevation of TH-IgA was significantly correlated to high levels of total serum IgA. An indirect immunofluorescence method did not demonstrate any cross-reaction between TH and liver tissue.

Acidosis, Renal Tubular↗
PubMed1981

Acute alcoholic cholestasis. Report of a case with in vitro studies of hepatic protein synthesis.

A patient is reported who developed acute cholestasis after alcohol abuse. Extrahepatic cholestasis was excluded at laparotomy. Liver microscopy showed cholestasis with slight parenchymal damage but was otherwise normal. In vitro measurements of hepatic protein synthesis indicated increased synthesizing capacity. This is the fourth reported case of so-called acute alcoholic cholestasis.

Acute Disease↗
PubMed1980

Evaluation of tests for Gilbert's syndrome.

The effect of caloric restriction (400 kcal for 24 hours) on serum total and unconjugated bilirubin was studied in 30 subjects with Gilbert's syndrome and in 22 patients with different liver diseases. The method could not completely differentiate between Gilbert's syndrome and liver disease, but an increase in unconjugated bilirubin of 15 micromol/l or more supports the former diagnosis. This limit gave a 100% specificity and a sensitivity for males of about 90% and for females of about 40%. I.v. nicotinic acid caused similar rises of unconjugated bilirubin as reduced caloric intake in eight subjects with Gilbert's syndrome, but most of the subjects preferred the latter test. Results from erythrocyte porphyrin determination in seven subjects with Gilbert's syndrome gave some support to the presence of dyserythropoiesis.

Bilirubin↗
PubMed1980

Prevalence of liver disease in patients taking salicylates for arthropathy.

110 patients with various arthropathies, mostly rheumatoid arthritis, treated with salicylates, were investigated for the presence of signs of liver disease attributable to this drug. An increased serum alkaline phosphatase level was observed in 9 of 96 ASA-treated patients with rheumatoid arthritis. However, this alteration could not be related to the use of salicylates, nor to the ingestion of any other antirheumatic drug. The hyperphosphatasemia persisted during a three-year follow-up in five of the nine patients.

Aged↗