Biomedical subjects
Publications and source records attributed to R Novak.
The pressure at dedicated mammographic units, indicated by a manometer, shows the pressure in the hydraulic system. The reading of this instrument is misleading because the pressure in the breast caused by the compression plate is considerably lower. Appropriate compression during mammographic examination may, however, rupture cysts.
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A 75-year-old female with a remote history of electroconvulsive-shock therapy and more recent care for psychotic depression died due to thromboembolic disease. Intranuclear inclusions were found to be widespread in her brain after autopsy. There was a paucity of the usual pathologic findings of herpes simplex virus (HSV) encephalitis, but light microscopic studies using antiserum to HSV type 1 demonstrated the presence of this agent in the intranuclear inclusions and in the cytoplasm of neurons and glial cells using immunoperoxidase staining methods. Immunostaining was also performed at the ultrastructural level and virus-like particles were identified. No immunostaining was obtained using normal control serum or antiserum to HSV type 2, while HSV type 1 or type 2 was demonstrated by immunostaining in control tissues. Control brain tissue from a group of psychotic and non-psychotic patients failed to show immunostaining for HSV antigen. This case is discussed in light of the current evidence pointing to a link between viral disease and psychosis.
Fast cochlear adaptation expressed as the percent of inhibition of the summed action potential, has been studied from the guinea pig cochlear responses to click trains, ramps, and steps in both directions. The transition time function of adaptation to constant click trains does not depend on the click strength, but rather on the click interval. At the background of steady state adaptation, click steps produce only transient changes of the adaptive state, opposite to step direction. Compared with constant train stimulation, adaptation is enhanced by descending click ramps, and diminished or reversed (near threshold) by ascending ramps.