Chylothorax complicating sclerotherapy for bleeding oesophageal varices.
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Biomedical subjects
Publications and source records attributed to R Mosimann.
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Of 26 patients who underwent distal splenorenal shunting 4 or more years ago (1969 to 1978), 10 died 3 to 87 months postoperatively (mean 38.5 months). Six deaths were due to liver failure, two to hemorrhagic peptic ulcer disease (the shunt remained patent in each patient), one to brain hemorrhage, and one to sepsis. Eight of the surviving patients resumed professional activity, one showed transient signs of encephalopathy, one had a single episode of recurrent variceal bleeding that could be managed conservatively, and no patient had ascites. Eight patients were investigated angiographically and endoscopically. Preoperative and postoperative measurements of the portal vein showed a decreased diameter in five patients and no opacification in the other three 29 to 97 months after surgery. At endoscopy four patients had small residual esophageal varices, one patient had none, and the other three had large varicosities with variceal pressures between 30 and 40 cm H2O in two and above 40 cm H2O in one. Although the incidence of postoperative encephalopathy and variceal bleeding was low after distal splenorenal shunting, the operation did not prevent a decrease in hepatopetal portal flow and did not always abolish the esophageal varices.
Ten alcoholic cirrhotic patients presenting with oesophageal varices underwent simultaneous measurement of wedged hepatic venous pressure and endoscopic variceal pressure. The latter was obtained by means of a pneumatic pressure gauge fixed to the tip of a gastrofibroscope. The correlation between these two parameters was highly significant.
In order to find the correlations existing between segmental and selective arterial blood flow volume, 20 healthy subjects have been submitted to calf venous occlusion plethysmography and Multichannel Digital Pulsed Doppler examination of the common femoral and popliteal arteries at rest. We found a linear correlation only between mean popliteal artery blood flow volume and plethysmographic calf blood flow volume (r = 0,41; p less than 0,01). We therefore suggest that venous occlusion plethysmography should not be used for the assessment of aorto-iliac and common femoral hemodynamics after direct arterial reconstructive surgery. Its use should be complementary to pulsed Doppler blood flow volume determination at the femoro-popliteal level, along with the usual pressure measurement.
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Our study attempts to establish a relation between the pressure in the esophageal varices and the clinical outcome in 18 patients in whom sclerotherapy for bleeding esophageal varices was performed. The measured pressure was compared to the endoscopic findings. Before sclerotherapy, a noninvasive manometric measurement was performed on the varices using a spheric membrane manometer fixed at the tip of an endoscope. Twelve of our 18 patients suffered repeated hemorrhage which led to death in five. We discovered a relation between the measured pressure and the outcome. Beside this, we measured the highest pressures in the largest varices. The relation that seems to exist between the pressure in the esophageal varices, the endoscopic findings, and the severity of the portal hypertension may provide new opportunities for research in this field.
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Amongst the surgical treatments that have been suggested for refractory ascites, the one that has met with the greatest success is the LeVeen shunt. It nevertheless involves certain risks and might even be fatal. The authors' brief experience in this domain has confirmed its positive immediate effects and has also brought to light some of its drawbacks. The large number of potential complications leads one to conclude that the LeVeen shunt should be reserved for refractory ascites and hepato-renal syndrome, and should not be prematurely employed in other situations.
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73 patients presenting with hiatus hernia and reflux oesophagitis verified endoscopically, were controlled and checked by endoscopy 5 to 15 years after surgical correction of reflux. In half of these cases the intervention consisted of a "fundoplicatio" and in the other half, of a "hemi-fundoplicatio" or closure of the angle of His. The long-term results show a higher degree of efficiency of the "fundoplicatio" particularly that which concerns the curing of the oesophagitis. The adjunction of a vagotomy-pyloroplasty in 9 patients showed an increase in the frequency of bile reflux in the stomach. The absence of cancer in the oesophagus in the 73 patients controlled after a period of many years, suggests that correction of the reflux and of the oesophagitis constitutes a high measure of efficiency.
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