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Biomedical subjects

R Moore

Publications and source records attributed to R Moore.

At least 469 records · Page 26Linked to original sources
PubMed1977

The importance of initial presentation and treatment upon the survival of patients with chondrosarcoma.

The effect of initial presenting symptoms, degree of tumor differentiation and type of surgical procedure on survival was evaluated in a 20 year review of 42 patients with chondrosarcoma. Therapy of patients presenting initially with a painless mass resulted in a median survival period longer than 13 years versus less than three years of the initial symptom was pain. Median survival time of patients with well differentiated chondrosarcomas was more than ten years compared with 1.2 years if the tumor was less well differentiated. Even if the sarcoma was nonresectable, these factors influenced the survival time. Since chondrosarcomas tended to recur locally rather than to metastasize, a number of patients who had a recurrence after the initial surgical excision could be saved by a more radical secondary operation.

Adolescent↗
PubMed1976

Movements of sodium and potassium into ejaculated boar spermatozoa suspended in seminal plasma and a biological salt solution.

Uptake of 22Na and 42K into ejaculated boar spermatozoa was measured in vitro. Cells were suspended either in seminal plasma or in a biological salt solution of essentially the same composition as boar seminal plasma. Samples were incubated at 30 degrees C. Correction was made for extracellular space in the centrifuged sperm pellet. This was determined as 22Na-space, which was less (P less than 0.001) than [14C] carboxyinulin space. Large differences were observed among individual ejaculates. The half-time for potassium uptake into the spermatozoa averaged 11.5 min, which is much faster than that for leukocytes or erythrocytes. When the spermatozoa were suspended in the biological salt solution, the initial rate of 42K uptake was significantly decreased. This may be due to disturbances of the protein components of the sperm membrane. The uptake of 22Na into the spermatozoa was slow. Sodium and potassium transport appeared not to be coupled in the 3/2 ratio which has been reported for erythrocyte membranes. The average concentration of sodium was 108 mM in seminal plasma and 26 mM in the spermatozoa (112 mmol/kg water and 38 mmol/kg water, respectively). The corresponding figures for potassium were 26 mM and 51 mM (27 mmol/kg water and 74 mmol/kg water). The random error for a single determination for the various methods used varied between 2.4 and 13.3% of the mean.

Analysis of Variance↗
PubMed1976

Comparison of ejection fraction calculated by nine different volume calculation methods.

Single plane right anterior oblinque ventriculography was performed on 25 patients with normal left ventricular contraction and on 25 with left ventricular akinesia or dyskinesia. The value of the left ventricular ejection fraction (EF) was calculated by 9 different methods, including a new one utilizing the mathematical model of a cone. All methods tested were appropriate for inter-group comparisons of EF. For inter-individual comparisons, however, only those methods described by Davila, Chapman, Dodge, Beranek, and our new method, are appropriate.

Angiocardiography↗
PubMed1976

A method to absorb scattered radiation without attenuation of the primary beam.

A method is presented for improving image quality by decreasing the scattered radiation. Two pairs of lead plates, one above and one below the patient, move in arcs with a common pivot point, the focal spot of the x-ray tube. The lower plates are separated by a 1-cm slot. The upper plates are also separated by a slot, the edges of which lie on common radii from the focal spot. The image is formed by moving the slots so that the X-ray beam emerging from the object sweeps across the film with a uniform speed during the exposure.

Humans↗
PubMed1976

The effect of valium on myocardial blood flow.

The effect of Valium on coronary blood flow was studied. In 18 patients undergoing coronary angiography, total and regional myocardial blood flow was determined by the 133Xe wash-out technique. A total of 39 pre- and 39 post-Valium injection wash-out curves were constructed. Results indicate (99% confidence) that intravenous Valium injection (0.1 mg/kg body weight) decreases myocardial blood flow 12--15%.

Angiography↗
PubMed1976

A device to measure roentgenographic structures.

A simple device and a nomogram are presented to permit rapid, accurate measurement of structures shown on roentgenograms. The arrangement is designed specifically for measurement of coronary vessels, but it can be adapted to other structures.

Angiography↗
PubMed1976

Hemodynamic assessment of obstructive aortoiliac disease.

Angiographic demonstration of obstructive aortoiliac disease is of paramount importance prior to surgery. Obstructive disease in the femoral popliteal system can only be surgically relieved if inflow is adequate. Severely stenotic lesions may be missed by angiography due to the oblique course of the iliac arteries and inability to obtain right angle views. Translumbar downstream catheterization of the abdominal aorta and puncture of both femoral arteries allows simultaneous pressure recordings. The injection of 30 mg of papaverine into the femoral artery assures maximal vasodilatation mimicking conditions under exercise. A minimal gradient at rest may become obvious following the injection of papaverine, indicating hemodynamically significant disease and warranting surgical correction. The technique has proved to be simple and valuable, and there have been no complications.

Aorta, Abdominal↗
PubMed1976

Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery.

The administration of delta9THC intravenously as a premedicant to oral surgery resulted in acute pronounced elevations in anxiety states, a predominance of dysphoria over euphoria, and varying degrees of psychotic-like paranoiac thought. Neural effects that appeared to promote these effects included distortions of perception with sensory delusions, and heightened sensory receptiveness including antalgesic impressions of surgery; autonomic and visceral arousal greater than control or placebo levels; lack of overt behavioral signals of distress due to depersonalization; and time disintegration leading to fear-inducing misinformation about real surgical events. Introverted subjects who generally were inclined to rely on drug solutions to their problems tended to respond poorly to surgical pain and anxiety with delta9THC. These results, obtained from subjects considered to have levels of presurgical apprehension that were average or below average, suggest that the environment in which high doses of cannabinols are experienced is a potent factor in determining the quality of the emotional response. A surgical environment containing even the mild stress of outpatient oral surgery appears to have the potential to precipitate undesirable emotional responses among cannabinol-intoxicated patients. There is continued high-level social use of cannabinols inour society, with an estimate of 40% to 55% among the college-age group seen frequently by oral surgeons. Results of this study suggest that clinicians should be prepared to detect the subtle signs of marijuana intoxication to protect their patients from further psychophysiologic complications during surgery.

Adolescent↗
PubMed1975

Current results from treatment of bladder tumors with total cystectomy at roswell park memorial institute.

Results of our recent cystectomy series revealed good survival for patients with superficial bladder tumors. The morbidity rate was low, 8.6 per cent. Our series showed a statistically significant postoperative morbidity rate in a high risk patient group, then justifying preoperative selection of patients as condidates for this major operation. However, we believe that despite relatively good results in reducing the morbitidy and mortality rates and improvement in survival, the over-all results in treatment of bladder tumors with operation alone are still unsatisfactory and there is an urgent need to develop and to investigate new and combined modalities of treatment.

Adult↗
PubMed1975

The evaluation of high-speed screen-film combinations in angiography.

Various high-speed screen-film combinations were evaluated to compare increase in speed, loss of resolution, and increase in radiographic mottle. Results indicate that the rare-earth film-screen system is the fastest and has a higher x-ray absorption efficiency. The Kodax X-Omatic screen has the greater resolving power but is slower than the high-speed calcium tungstate system. A smaller focal spot can be used with the fast speed of the rare-earth system to increase resolution.

Angiography↗
PubMed1975

Regional Myocardial Blood Flow Measurement in the Evaluation of Patients with Coronary Artery Disease.

Myocardial imaging with 133-Xe and a gamma camera was employed to evaluate total and regional myocardial blood flow. The technique detected vasodilatation after injection of papaverine or diatrizoate. Contrast medium caused transient vasodilatation with return to baseline flow within five minutes. Myocardial tissue flow tended to decrease as coronary artery stenosis became more severe. There was overlap of flow measurements in patients with and without coronary artery disease. Coronary flow measurements made at rest are not considered to be an essential clinical tool. gpreater diagnostic benefit is obtained from the scintigram which distinguishes between akinesia caused by ischemia and akinesia due to extensive scarring.

Contrast Media↗
PubMed1975

Regional myocardial blood flow measurements before and after coronary bypass surgery. A preliminary report.

Myocardial blood flow in 16 patients before and after coronary bypass surgery in conjunction with coronary angiography, left ventricular function measurement, and graded exercise test. Radioactive 133-Xe was injected into the coronary artery or bypass graft and the washout was recorded by an Anger camera. Myocardial blood flow increased in 11 out of 14 patients and decreased in three patients. The average flow was 55 (plus or minus 6) preoperatively and 96 (plus or minus 10) ml 100 g/min postoperatively. Increase of blood flow occurred in both the bypassed left anterior descending coronary artery (LAD) region and the nonbypassed left circumflex coronary artery (LCIR) region. The postoperative flow increase and the absolute postoperative flow values are higher with saphenous vein than with mammary artery grafts. Statistically significant correlation is not found between myocardial blood flow changes and exerice tolerance. The volume measurements (end diastolic volume, stroke volume, ejection fraction) remained unchanged.

Adult↗