[One-stage sensible phalloplasty in the transsexual female].
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Humans↗
Biomedical subjects
R Meyer
Publications and source records attributed to R Meyer.
[Total and partial reconstruction of the nose].
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Humans↗
The synergistic interaction of hydrocortisone and dibutyryl cyclic AMP during enzyme induction in hybrids between rat C6 glioma cells and FU5AH hepatoma cells.
The hormone-responsive enzymes tyrosine aminotransferase and glycerol-3-phosphate dehydrogenase were studied with respect to current models of the mechanism of glucocorticoid/cAMP interaction during the induction of enzyme activity in responsive cell hybrids between rat C6 glioma cells and rat FU5AH hepatoma cells. The results of experiments involving protein and mRNA synthesis inhibitors, sequential addition of inducers, and the assay of cyclic-AMP-dependent protein kinase could not be adequately explained by any one model of inducer interaction. Comparison of the hybrid clones revealed the presence of factors that may modify induction but that are not essential for synergistic induction.
Amanitins↗
The solution in functional rehabilitation after destruction of the larynx: the tracheostoma closed.
A bayonet-shaped airway allowing free respiration and undisturbed deglutition was reconstructed in 2 young women who had undergone tracheotomy and radiotherapy for thyroid carcinoma. The laryngeal vestibule, glottis, and subglottis had been destroyed, and the air passages were closed. An external gutter and an anterior tracheal wall were created in a multistage procedure. In 1 patient, the hypopharynx and upper esophageal segment were reconstructed with bilateral pectoralis major musculocutaneous flaps, which disfigured the breast. The two displaced nipple-areola complexes were properly repositioned using skin expanders and island flap transfer, and the breast was remodeled with prostheses. Our results suggest that this method of laryngotracheal reconstruction may also be applied in laryngectomized patients in whom only part of the epiglottis and the aryepiglottic folds remain. Although the procedure is lengthy and difficult, it is recommended for extensive lesions in fully cooperative patients.
Adult↗
One-stage phalloplasty in transsexuals.
Until now, phalloplasty in transsexuals has been done with cutaneous and musculocutaneous flaps from the abdomen or the thigh in multiple procedures over a long period. We report a one-stage phalloplasty in female transsexuals with a modified Chinese forearm flap, including the cutaneous nerves anastomosed to the genital branches of the ilioinguinal and iliohypogastric nerves and the perineal branches of the pudendal nerve to obtain true genital sensibility. Immediate hysterectomy and vaginal closure are performed, providing vaginal skin to complete the neoscrotum built up with the labia and to cover the glans. A vaginal flap draped around the catheter provides the urethra, which is stripped through the dermal tube of the forearm flap acting as a corpus spongiosum. Autogenous costal cartilage is used as a stent for reinforcement, substituting for the corpora cavernosa. The donor forearm area is covered with split skin.
Female↗
Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea.
An ELISA assay using a monoclonal antibody (ET-4-A-4) that recognizes a sulfated carbohydrate epitope in both keratan sulfate type I (corneal) and type II (skeletal) was employed to quantify keratan sulfate in serum and corneal tissue from patients with macular corneal dystrophy (MCD). This assay disclosed significant quantities of keratan sulfate in the serum in 45 healthy individuals (251 +/- 78 ng/ml), and in 66 patients with various corneal diseases (273 +/- 101 ng/ml). In contrast keratan sulfate was not detected (less than 2 ng/ml) in the serum of 16 patients with histopathologically confirmed MCD. Keratan sulfate was also detected in extracts of normal corneas and corneal tissue with a variety of pathologic conditions, but was virtually absent in corneal tissue from five patients with MCD. In corneas with MCD the chondroitin sulfate/keratan sulfate ratio was considerably higher than that of all normal and pathologic corneas studied. Since keratan sulfate in the serum appears to be derived predominantly from the normal turnover of cartilage these studies strongly suggest that the defect in keratan sulfate synthesis in MCD is not restricted to corneal cells and that MCD is one manifestation of a systemic disorder of keratan sulfate. The cartilage changes, however, do not have clinical significance. Moreover, since keratan sulfate can be detected in the blood of newborns it should be possible to diagnose MCD prior to corneal opacification.
Antibodies, Monoclonal↗
Nosocomial transmission of delta hepatitis.
A previously asymptomatic carrier of hepatitis B virus receiving chronic hemodialysis developed acute delta hepatitis. The patient regularly received dialysis treatments on the same machine as a parenteral drug abuser with hepatitis B surface antigen (HBsAg)-positive chronic hepatitis whose serum was strongly positive for delta antibody. The drug abuser had a major bleeding episode that caused extensive environmental contamination 3 months before onset of illness in the index patient. No other patients receiving dialysis or staff members had evidence of delta infection. A surgeon previously infected with hepatitis B from the same parenteral drug abuser also had delta antibody. Testing for delta virus is indicated for both HBsAg-positive parenteral drug abusers and patients with hemophilia receiving chronic hemodialysis. All patients who are HBsAg- and delta-positive should receive dialysis separately from patients who are HBsAg-positive and delta-negative. Susceptible patients on dialysis and staff should receive hepatitis B vaccine to protect against both hepatitis B and delta virus infection.
Adult↗
[Use of fibrin glue in plastic surgery: reconstruction and cervicofacial esthetics].
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Aprotinin↗
[Esthetic surgery of the lower third of the face].
Various techniques for the correction of the aging perioral region are discussed. The authors emphasize the fact that one of the reasons of presenile lipwrinkling is soft tissue loss. As a remedy dermis grafting is recommended and is described in detail. The procedure can be combined with the standard techniques of perioral aesthetic surgery.
Face↗
[Morvan's fibrillary chorea following chrysotherapy].
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Arthritis, Rheumatoid↗
[Preoperative patient education of gynecologically ill patients].
400 gynecologically ill patients were questioned after having had on operation. A causal relationship was found between the state of education and the quality of the answers given concerning the importance of the practised operation. There was no causal relationship between the patients ages and their answers. In repeated gynecological operations there was an improvement of knowledge of the patients about the necessity of intervention. The authors plead for pre-operative information before gynecological operations adequate to the level of the patients education.
Cervix Uteri↗
[Text processing in pathology. Setup and content of text data for autopsy reports].
Elaboration of a text catalogue of the most important terms and findings is essential for computerized reports to be effectively introduced in pathology. Such a catalogue must be constructed so, that the majority of reports or findings, respectively, can be accommodated or generated. Structure and content of a text catalogue are illustrated with examples for autopsy reports.
Autopsy↗
[Postmortem ion analysis of the myocardium in surgically correctible heart malformations].
Commonly, children dying after operation on congenital cardiac malformation, show only minor histological changes in the myocardium. We have attempted to correlate the myocardial ion (Na+, K+, Ca2+) composition with the probable severity of hypoxia. Mean Ca2+ content has been plotted against the mean Na+/K+ ratio of every heart in the present study. A good correlation between these two parameters was demonstrated with full separation of controls and hearts with congenital malformations.
Calcium↗
Determination of nucleotide pools in plant tissue by high-performance liquid chromatography.
A procedure for the determination of nucleotide pools in plant tissue by HPLC is described. Sample preparation includes the extraction with 0.4 M HClO4, a purification step, which proved to be essential, on a disposable prepacked phenyl-bonded column, neutralization by KOH, and concentration by freeze-drying. The determination of a broad spectrum of ribonucleotides including the ribonucleosides was performed by combining anion-exchange and reversed-phase HPLC. Data are presented for suspension-cultured cells of Nicotiana tabacum and Datura innoxia and for the leaf and root of tobacco.
Chromatography, High Pressure Liquid↗
Myocardial bioptic findings in correlation with TL-201 imaging and hemodynamic parameters in patients with latent cardiomyopathies suspected of having myocarditis.
Sixty-eight patients (24 males, 44 females, mean age 37.2 years) belonging to NYHA classes I and II were investigated. All patients had a nondilated ventricle as well as hemodynamic criteria of "latent cardiomyopathy." In 78% of the patients, a high susceptibility to infection, frequent angina, or possible myocarditis were found. In 75.5%, the mean pulmonary artery pressure was abnormal. T1-201 scintigraphy revealed perfusion defects in 78%. Dyskinesia or hypokinesia were found in 52%. The left ventricular ejection fraction was normal in 74%. On biopsy, pathologic findings were detected in 60.9% of patients with a high frequency of hypertrophy and fibrosis (50%). In two patients, lymphocytic infiltrates were found. Immunohistologically, deposits of complement, IgG, IgM, and gammaglobulin, mainly in the sarcolemma, could be identified in 19.1% of cases. The myocardium was normal in 39.1%; insufficient material was found in 5.9% of patients. Morphologic, scintigraphic, and hemodynamic findings could not be correlated but the combination of two pathologic parameters permitted diagnosis. Biopsy was the most effective diagnostic method in myocarditis.
Adolescent↗
Effect of an enhanced natural radioactivity on mammal fertility.
Male and female mice of the BALB/c strain were placed on the floor of a hut built at a site of the Permian Basin of Lodève (Southwest France) where the dose rate of gamma radiation amounts to about 10 mrad/h. In previous experiments such high natural radioactivity was shown to induce point mutations in plant material as well as chromosome aberrations in somatic cells of experimental mammals. Controls were kept near the radioactive site under comparable conditions. After the exposure period, the animals were mated in our laboratory, with control mice of the same strain. Due to the high radiosensitivity of mouse oocytes, the fertility of the exposed females was drastically reduced in spite of the fact that the dose received did not exceed 13.8 rad. The fertility of the males exposed to 13 rad, 15 rad or to 45 rad was increased above the control values but was reduced for the animals receiving 63 rad. Analysis of the results show that the differences in fertility are mainly due to a decrease in the number of sterile pairs when males have been exposed to doses upto 45 rad and to an inverse effect when animals received 63 rad. Since histology and weight of the testes suggest that the germ cell population was normal, one has to conclude that the variations in fertility result from physiological effects.
Animals↗
Cutaneous vasostomy: technique for treatment of chronic and recurrent epididymitis.
We describe a method for treatment of patients with chronic and recurrent epididymitis. Six of 7 patients (86%) treated with this procedure between 1977 and 1980 have had no recurrent episodes of epididymitis to date. We discuss the comparative benefits of this procedure as related to other surgical treatments for acute, chronic, and recurrent epididymitis.
Aged↗
Total reconstruction of the "end-stage" cleft lip and palate deformity.
The purpose of this paper is to present a 5-year experience using a comprehensive surgical approach to reconstruct what we have chosen to call the "end-stage cleft lip and palate deformity." The deformity consists of varying degrees of midface retrusion, malocclusion, nasal deformity, and lip deformity. Most of the patients afflicted had unacceptable upper lip anatomy characterized by tightness and lack of cupid's bow and bulk. All had severe palatal scarring with resulting arch collapse and severe malocclusion. Most had had multiple surgical attempts to improve nasal aesthetics using standard rhinoplasty techniques with little or no improvement. The procedure involves splitting the upper lip with incisions extending into the upper buccal sulcus and rim of the nose allowing wide skeletalization of the maxilla and osteocartilagenous nasal skeleton. LeFort I or II maxillary advancement, nasal reconstruction, and upper lip modification (with Abbé flap if indicated) are done. The jaws are placed in intermaxillary fixation for 6 to 8 weeks. This comprehensive approach has been used in 16 patients, aged 15 to 29 years, with follow-up of up to 5 years. Excellent functional and aesthetic improvement has occurred in all patients, and complications have been minimal.
Adolescent↗