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Biomedical subjects

R M Taylor

Publications and source records attributed to R M Taylor.

At least 217 records · Page 12Linked to original sources
PubMed1981

The stimulus-induced release of unmetabolized 5-hydroxytryptamine from superfused rat brain synaptosomes.

A number of existing techniques have been modified to produce an improved technique for examining the depolarization-induced release of unmetabolized 5-hydroxytryptamine (5-HT) from drug-free superfused synaptosomes. Synaptosomes which have been pre-loaded with [3H]5-HT are set up in perfusion chambers and continuously perfused with medium. Serial samples of effluent perfusate are collected on ice and the released 5-HT and 5-hydroxy-indole acetic acid (5-HIAA) are separated by ion exchange chromatography. The technique provides reproducible Ca2+-dependent responses to K+ depolarization in the absence of monoamineoxidase inhibition and free from the interference of re-uptake. The advantages of the use of the system in examining transmitter release and its modulation is discussed.

Animals↗
PubMed1981

Renal transplantation in patients on continuous ambulatory peritoneal dialysis.

Over a two year period 15 patients on CAPD and 65 patients predominantly treated by haemodialysis received first grafts. There was no difference in graft survival in these two groups. In the continuous ambulatory peritoneal dialysis (CAPD) patients there were no post operative episodes of peritonitis, apart from one patient who had peritonitis at the time of transplantation. No technical difficulties were encountered at the time of grafting. CAPD is not a contraindication to transplantation.

Adolescent↗
PubMed1980

Plasma suppressive activity and kidney graft survival.

Over the past few years many centres have shown that blood transfusions given to potential renal transplant patients are beneficial to subsequent graft survival. Results from this centre have shown that an elevated ability of plasma to suppress lymphocyte reaction to antigen is associated with blood transfusions in chronic renal failure patients. In a prospective study, plasma suppressive activity was measured at the time of transplantation in 49 patients who were followed for between 3 and 15 months. Results showed that patients with a low level of plasma suppressive activity were at risk from early graft loss due to acute rejection. Furthermore, most of the suppressive activity was related to the naturally occurring plasma protein. alpha 2-macroglobulin. This prospective study reports a significant association between low plasma suppressive activity and early kidney graft loss through rejection, and suggests an explanation for the beneficial effects of blood transfusion on graft survival.

Blood Transfusion↗
PubMed1980

A new finding relating to transfusion and renal transplants.

Results in 29 recipients of second renal transplants from cadaver donors show a significantly better graft survival at 1 year of 90% in 10 recipients who had not received blood transfusion before their first transplant compared to 41% in 19 recipients who had been transfused prior to their first transplant (P = 0.025).

Blood Transfusion↗
PubMed1980

Compressed third molars--a suggestion.

The author's 'Variation in morphology of teeth' (1978) reported findings in extracted teeth, part of which involved intensive study of deformity in maxillary third molars. This suggests that abnormal developmental relations could have obstructed or perverted the tooth's potential morphology. Some third molar characters, seen also in well-developed palates and in various ethnic groups, may reflect a certain combination of normal variables. These latter teeth have hitherto aroused little comment other than their description as 'compressed'.

Aging↗
PubMed1980

Large color differences and the geometry of Munsell color space.

Multidimensional scaling of subjective similarity estimates for colors varying extensively in Munsell hue, value, and chroma produced a configuration that concurred with the postulated organization of Munsell color space, and indicated step-size relationship between attributes. Implications for the determination of color difference are discussed.

Color Perception Tests↗
PubMed1979

The medical management of renal artery stenosis in transplant recipients.

The investigation, management and clinical course of 12 patients developing stenosis of the renal artery following transplantation are described. The possible aetiology of the three arteriographic patterns of stenosis is discussed. Surgical correction of graft arterial stenosis is difficult and may lead to graft loss, whereas the outcome with antihypertensive drug treatment with or without anticoagulants is good. Surgery should only be contemplated if medical treatment is failing or if renal function is deteriorating.

Anticoagulants↗
PubMed1979

Volar melanotic macules.

Asymptomatic light brown or tannish-gray macules are seen on palms and/or soles of black patients, and occasionally on the volar surfaces of whites. They may be mistaken for lesions of secondary syphilis or other postinflammatory hyperpigmented dermatoses. Histologic examination of 14 specimens obtained at necropsy showed purely epidermal hyperpigmentation of all epidermal layers; or (3) melanin restricted to large dendritic melanocytes without appreciable transfer to keratinocytes. The number of melanocytes was not significantly increased, and with one exception, there were no nevus cells. These volar melanotic macules have close clinical and histologic resemblance to melanotic macules observed occasionally on the vermillion area of the lips.

Adult↗
PubMed1978

Adverse effect of splenectomy in renal transplantation.

Between January 1968 and June 1974 at Newcastle upon Tyne, 63 patients underwent splenectomy in association with transplantation; 45 of these had splenectomy with bilateral nephrectomy before (20) or at the time of (25) transplantation; 18 had post-transplant splenectomy for leucopenia. Mortality was significantly higher in splenectomized patients than in 136 non-splenectomized controls. Of the 63 splenectomized patients, 25 died within 1 year of transplantation, 12 of severe infection associated with leucopenia. Although splenectomy produced a temporary rise in white cell count, leucopenia during the first year of immunosuppressive therapy was not significantly less frequent in splenectomized patients than in controls. There was no significant difference in graft loss between the splenectomy and control groups. It is concluded that splenectomy is contra-indicated in patients who are to undergo renal transplantation and confers no benefit when carried out because of leucopenia developing after renal transplantation.

Azathioprine↗