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Biomedical subjects

R M Patterson

Publications and source records attributed to R M Patterson.

97 records · Page 6Linked to original sources

A comparison of double-plate fixation methods for complex distal humerus fractures.

A modified method of fracture fixation of complex distal humeral fractures with medial and lateral plates and bolts was biomechanically tested and compared with previously described fixation techniques. Compressive stiffness coefficients were determined for three classes of fixation before and after fatigue cycling. This procedure was followed with compressive loading to failure. The results show that in the most unstable fracture type tested this new fixation method provides increased strength and stability. Early clinical follow-up examinations of patients treated with this technique show that this method is a reasonable fixation alternative for the complex distal humerus intercondylar fracture.

Adult↗

Clindamycin and ibuprofen effects on chlamydial salpingitis in mice.

To evaluate the effects of clindamycin and ibuprofen on a model of upper genital tract chlamydial infection in mice, 64 Swiss Webster white mice were inoculated in the left ovarian bursa with a mouse pneumonitis strain of Chlamydia trachomatis. Chlamydia-inoculated mice received clindamycin, ibuprofen, clindamycin and ibuprofen, or no treatment. Mice were killed at intervals, and their genital tracts were examined grossly and microscopically for evidence of infection and cultured for Chlamydia. Sixty-seven per cent of inoculated, untreated mice manifested gross evidence of inflammation compared with 22.4% of mice in any treatment group (P less than .025). C. trachomatis was isolated in 10.2% of mice treated with any drug regimen, whereas 46.7% of untreated mice were culture-positive (P less than .025). In this model, therapy with clindamycin, ibuprofen, or both drugs in combination decreased gross and histologic evidence of inflammation as well as the rate of recovery of C. trachomatis from the genital tract.

Animals↗

Baculovirus and insect cell gene expression: review of baculovirus biotechnology.

The BEVS continues to evolve as a powerful, flexible tool for molecular biology, protein function, and biomedical research. Future developments offer the promise of replacement of hazardous chemical insecticides with environmentally safe biopesticides, construction of baculovirus vectors which encode genes for specific post-translational modifications, and establishment of efficient, stably transformed insect cell lines. FDA approval of BEVS-produced products offer the prospect of new biopharmaceuticals, in particular human therapeutics and vaccines, to improve human health and increase the quality of life for millions of people.

Animals↗

Exposure assessment for electric and magnetic fields.

Exposure assessment for extremely low frequency (ELF) electric and magnetic fields (EMF) is discussed. It is suggested that such assessments can be designed by attempting to mimic the receptor's experience of interest. Present efforts are, however, hampered by the lack of clearly defined human health effects, or even important interaction mechanisms, which might be used to define the appropriate exposure measure, the experience of interest. The state of the art of ELF EMF exposure assessment is described, including the use of surrogates, models, and available instrumentation. Data indicate that magnetic field levels in the home are of the order of 0.1 microT and that nonoccupational total exposures may best be predicted by levels in the bedroom. Occupational exposures may be orders of magnitude higher where high currents are present.

Carbon Monoxide↗

Variability and consistency of electric and magnetic field occupational exposure measurements.

There is widespread scientific and public interest in possible health effects from exposure to electric and magnetic fields at frequencies associated with electricity use. Electric and magnetic field exposure assessment presents specific problems, among which are the inherent variability in exposure, the lack of robust statistical summary measures, and the lack of an accepted metric based on biological response. These pose challenges in defining distinct exposure groups, a basic goal for exposure assessments used in epidemiological studies. This paper explores the extent to which distinct electric and magnetic field exposure groups can be defined, by examining the variability and consistency of occupational electric and magnetic field exposure measurements among studies and within individual studies. Principal analyses are made by job titles because they are the most frequently used descriptors for stratifying occupational exposures to electric and magnetic fields. Methodological issues affecting the degree of consistency in measured electric and magnetic field exposures among occupational environments are also examined. Exposures by job title reported from electric and magnetic field measurement studies are summarized by general job category and industry. Analyses are performed both within and between job categories. Distributions of daily measured exposures for job categories taken from three large studies in the U.S. electric utility industry are compared to investigate consistency of exposures at a more detailed level. Analyses of reported personal exposure measurements from many studies and countries are consistent with less rigorous observations made heretofore on the basis of individual studies. In these studies, significantly elevated electric and magnetic field exposures are found in the electrician, lineworker, and substation worker categories; significantly elevated magnetic field exposures are also noted in the generation worker category; and magnetic field exposures in these groups are consistent across countries. Analyses within and among the elevated exposure job categories indicate that there are no significant differences between them. Among the studies, it is not possible to distinguish between exposures for well-defined groups within the categories, such as between transmission lineworkers and distribution lineworkers in the lineworker category; between generation operators and generation mechanics; or between substation operators and substation maintenance workers. This information provides a context for past studies and will help future efforts to define distinct occupational exposure groups exposed to electric and magnetic fields. Compilations of measured personal exposure data by industry and job title have been prepared as appendices (available from the author upon request).

Analysis of Variance↗