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Biomedical subjects

R Loire

Publications and source records attributed to R Loire.

At least 235 records · Page 13Linked to original sources
PubMed1977

[Fatal emboligenic ulcerative endomyocardial fibrosis in filariasis].

A man of 54 had been treated over a 15 month period for pulmonary tuberculosis when aged 41, and had lived on the Ivory Coast and then in the Cameroons for 20 years. Eye signs were discovered in January 1971, and these, together with an eosinophilia, pointed to a possible filariasis which was later confirmed by immunofluorescence and the fixation of complement. Three months later, the patient developed congestive cardiac failure. On the 4th day of treatment with Notizine, multiple systemic emboli occurred, leading to death. Autopsy showed endomyocardial fibrosis with multiple ulceration of the left ventricle, the site of the emboli. The aetiology from filariasis and the mechanism of ulceration of the parietal endocarditis are discussed.

Aorta, Abdominal↗
PubMed1977

[Cause of death in recent myocardial infarct. Correlation between extent of necrosis and clinical, electrocardiographic and anatomical findings].

A retrospective study of 100 case notes of patients who died from a recent myocardial infarction (less than one month before death) has established the causes of death: cardiac failure (52), rupture of the heart (40), major pulmonary emboli (3), primary irreversible ventricular fibrillation (2), unexplained death (3). Study of the extent of the necrosis by the technique of segmentation of the ventricular mass has allowed us to clarify the correlation between the "index of extent" ("i"), an the clinico-pathological findings. It has been noted in particular that those infarctions complicated by cardiogenic shock and/or by bilateral bundle branch block were those with the highest value of index of extent (i = 8.91, i = 9.40); also that cardiac failure and ventricular tachycardia were found in the extensive infarctions (i = 7,33, i = 9.52); also that rupture of the outer wall and pulmonary thromboses complicated infarctions of very small extent (i = 4,80, i = 5,67). It would not seem possible to reduce the hospital mortality of infarctions significantly, since it is essentially linked with circulatory failure caused by extensive necrosis, and with ruptures of the heart which are unpredictable and untreatable.

Arrhythmias, Cardiac↗
PubMed1976

Histological arguments for collagen and elastin synthesis by primary cultures of rat aortic media cells.

Using the histological staining methods of Weigert and of Masson on primary cultures of rat aortic media cells, we obtained additional proofs of the smooth muscle cell's ability to secrete collagen and elastin in vitro: the percentage of positive flasks with aorta rings was the same throughout the follow-up, but increased gradually for the new tissue growing around the rings.

Animals↗
PubMed1976

[Intermediate and long-term results of multivalve prostheses].

Over a period of observation of 4 years maximum, there is no significant difference between the estimated survival time (by actuarial calculation) for patients with single and for those with double prostheses. Wihin the year following operation there is not significant difference between single and double prostheses as regards: the incidence of bacterial endocarditis, of pyrexias of unknown origin, of hepatitis, of haemolytic anaemia, of bleeding complications or incidents, of coronary of peripheral ischaemic episodes, or of reduced cardiac volume. On the other hand, there is a significant difference in the incidence of neurological defects (21% for the double prosthesis group, and 5% for the single prosthesis group, p less than 0.005 and or right ventricular failure (18% and 7% respectively, p less than 0.05) in the two groups.

Heart Valve Prosthesis↗
PubMed1976

[Thrombosis of the coronary sinus due to right endo-ventricular stimulation].

In a patient with a primary cardiomyopathy, anatomical investigation allowed us to find a total old organised thrombosis of the coronary sinus associated with the presence of a right ventricular stimulator of a pacemaker. A brief review of the literature reveals that cardiac thombosis is a surpising and rare complication of a residual intracavitary pacemaker, even if it is located in the coronary sinus.

Aged↗
PubMed1976

[Chronic pulmonary heart disease during ventriculo-atrial shunts in children].

This grave complication is a major cause of mortality in ventriculo-atrial shunts in children with hydrocephalus. It occurs at a much higher rate than with long-term indwelling intracavitary pacemakers, which suggests that the shunt procedure is responsible for either chronic infection or the introduction of cerebral thromboplastin.

Cardiac Catheterization↗
PubMed1975

[Rupture of the tricuspid cordae simulating a right intraventricular tumor].

Ruptured chordae tendinae of the tricuspid valve is exceptional. It results in an intense valvular incompetence through systolic eversion of one leaflet. In fact, this is not always the case, and in patient reported, the clinical picture suggested an obstacle to right ventricular ejection with paroxysmal phenomena of the faintness type, indicating the temporary obstruction of the pulmonary pathway. Right cine-angiocardiography demonstrated a mobile intraventricular neoformationreaching in systole the pulmonary sub-valvar area. No tumour was found on operation. The patient died in the post-operative period. On post-mortem examination there was a rupture of tricuspid chordae tendinae and a raise of the anterior leaflet of the tricuspid valve into the pulmonary infundibulum. Rupture could be related to a severe thoracic trauma which had occurred 17 years previously.

Cardiomegaly↗
PubMed1975

[Biopsy of the pericardium. Diagnostic value in subacute and chronic pericarditis, apropos of 70 cases].

The aetiology of pericarditis is often difficult to assess. To try to clear up this problem, a pericardial biopsy through a left lateral thoracotomy was performed in 70 cases in which the cause could not be established by the usual means (including pericardial paracenthesis in 32 cases). They included either subacute pericarditis, dry or with effusion (biopsy being undertaken as an average 45 days after the clinical onset), or chronic pericarditis with effusion. Tuberculosis was thus demonstrated in 14 cases (8 of which were aged more than 60 years), inaugural pericardial tumours in 8 and suppuration in 3 cases. Microscopical examination gave support to pathogenic hypotheses concerning cholesterol pericarditis (5 cases) and multi-recurrent pericartitides (6 cases). By elimination with a high probability) of tuberculosis and tumours, it demonstrated definitely the diagnosis of post-radiotherapy pericarditis with effusion (4 cases) pericarditis with normal serous membrane (4 cases) and "idiopathic" forms (23 cases of common sclerogenous subacute inflammation). The inocuity of this method, its more accurate results than those obtained by cytological and bacteriological examination of the pericardial fluid obtained by paracenthesis, should induce to consider this procedure more often in the cases of pericarditis when the aetiology remains doubtful; not to mention the benefit derived from surgical drainage which results in a quicker and more complete cure than repeated paracentheses of chronic and subacute pericardial effusions.

Acute Disease↗
PubMed1975

[Myxoma of the left ventricle. Apropos of a successfully operated case].

Left ventricular myxomata are exceptional (12 published cases). In the case reported, the clinical picture included emboli (cerebral and coronary) and syncope. Auscultation, the electrocardiogram and the phonomechanocardiographic tracings suggested an impaired left ventricular ejection, while the left ventriculography demonstrated the tumour and the coronary arteriography its vascular relationship with the right coronary artery. Cure was obtained by surgical removal. In that respect, an attempt was made to describe the clinical and paraclinical bases for the diagnosis of the myxomata of the left ventricle.

Child↗
PubMed1975

[Giant cell myocarditis. Attempt at interpretation, apropos of 3 cases].

Three cases of giant-cell myocarditis were observed, and 63 comparable cases were published in the literature. On the basis of this material, the significance of this disease was studied, which was considered for long to be of "granulomatous" origin, while it seems to be a peculiar histopathologic type of myocardialgeneration. The cause for this necrosis remains unknown; in spite of as complete as possible investigations in one of the three cases (in which death was preceded for labile recurring lung infiltrates during eleven months) no cause could be demonstrated.

Adult↗