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Biomedical subjects

R Laroche

Publications and source records attributed to R Laroche.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Current strategies in the campaign against Plasmodium falciparum malaria in an area resistant to 4-aminoquinolines].

Confronted with the extension of chemoresistance of P. falciparum and the gradual renunciation of the fight against the vectors, it is important nowadays to manage better the means of fighting in the zones where chloroquine resistance exists. If preventive treatment of chills by 4-aminoquinolines is still able to realize prevention of mortality, treatment of all confirmed chills by P. falciparum has to combine sulfadoxine-pyrimethamine with quinine or amodiaquine.

Aminoquinolines↗
PubMedDate not supplied

[Response of Plasmodium falciparum to quinine in a hospital environment in a chloroquine-resistant region. Bujumbura, Republic of Burundi].

Plasmodium falciparum's response to quinine (7.5 g of base in 5 days) was studied in vivo in 58 adult patients hospitalized in 1985--47% presented a pernicious malaria fever three deaths were registered during treatment, two of them attributed to late hospitalization, and the third patient was struck down by a sudden acute hepatitis. Three days after treatment started 89 of the patients did not present any asexual forms. At day 7, all patients responded favourably to the treatment. Parasitemia lowered very quickly whatever the route of administration had been. Quinine had no effect on production of gametocytes during the first four days. Clinical improvement is rapidly observed and the side effects of quinine disappeared when stopping the treatment. Despite the presence in the region of an important resistance of Plasmodium falciparum to chloroquine (80% specimens), one can conclude to a satisfying susceptibility of this parasite to quinine, provided posology and divided doses are respected.

Adolescent↗
PubMedDate not supplied

[Principle aspects of acquired immunodeficiency syndrome (AIDS) in adults in Burundi].

The authors describe their experience of the infection by the virus of the human immunodeficiency HIV-1 in Burundi. The acquired immunodeficiency syndrome was brought to light in 1983 by the emergence of cryptococcal meningitis, Kaposi's sarcomas, disseminated candidiasis. 109 cases of infection by the virus of the human immunodeficiency (HIV) AIDS related complex, or acquired immunodeficiency syndromes, were observed in 8 months and are related in this paper. The authors elucidate the spread and amplify the role played by lorry drivers. The frequency of recent case history: tuberculosis, zona, sexually transmitted diseases (41%). Clinical manifestations have been studied according to their clinical stage: 28 patients are AIDS related complex (25%), 81 are acquired immunodeficiency syndrome. One have to notice the frequency of tuberculosis at the stage of acquired immunodeficiency syndrome, of digestive parasitoses, not only coccidiosis, but also strongyloidiasis and colonic amoebiasis, cryptococcal meningitis, and encephalopathies caused by the virus of human immunodeficiency (HIV) at the period of AIDS. Lethal evolution is fast: 28 out of the 81 AIDS were observed up to their end, occurring in less than 60 days, as an average. Lastly, numerous opportunistic infections cannot be diagnosed because the lack of technical facilities.

AIDS-Related Complex↗
PubMedDate not supplied

[Tropical AIDS and tuberculosis. Apropos of a survey carried out in Bujumbura within the direct setting of HIV-seropositive and -seronegative tuberculous patients].

During a survey carried out in Bujumbura (Burundi) within two selected groups of H.I.V. seropositive and H.I.V. seronegative tubercular patients and their respective family, the authors noted that H.I.V. + patients reacted poorly to the specific treatment and they have continued to disseminate Mycobacterium tuberculosis after one year of treatment and consequently they have contaminated their family. They often have showed some drug reactions, in particular to TBE 1.

Adult↗
PubMedDate not supplied

[Human brucellosis in Burundi. Serologic survey in Rusizi Plain].

A serological survey was carried out on human brucellosis in Rusizi plain in Burundi from october 1984 to september 1985: 1,087 human sera were investigated by means of the rose bengal test and the technic of Wright's sero-agglutination. It comes out of this survey that: the aggregate prevalence of positive serology is 6.6%; such a prevalence is significantly higher in professionally at risk people (7.9%) than in people contaminated by food (3.5%).

Adult↗
PubMedDate not supplied

[Early congenital syphilis (7 cases observed in Bangui Hospital Central African Empire) (author's transl)].

In an infant of good condition, skin changes, anemia, hepato-splenomegalia and more over radiological osseous changes are symptoms of great value which are to be confirmed by a serological test of the baby and its mother. Treatment is very effective but it would be better to protect the foetus by an early detection and treatment of the syphilitic pregnant woman.

Antigens, Bacterial↗
PubMedDate not supplied

[Cryptococcosis in Burundi in 1985. Report of 30 cases].

Over a period of 23 months, 30 cases of cryptococcosis have been studied in Bujumbura (Burundi). Through them, epidemiological and clinical aspects have been underlined, and attempts have been made to establish links between cryptococcosis and A.I.D.S., which is significantly frequent in Central Africa. Cryptococcosis strikes young adults (40% between 30 and 35 years of age). Its high frequency in Bujumbura among patients infested by A.I.D.S., suggest some thoughts. A.I.D.S. in Central Africa, and particularly in Burundi, presents some peculiarities linked to surrounding and possibilities of diagnosis: opportunistic diseases are of different frequency in temperate or tropical climates: pneumocystosis are more frequent in U.S.A. but cryptococcosis and candidosis are more frequent in Africa because their diagnosis is easier. lack of classical risk factors in African populations is known, but other risk factors have to be taken into consideration: tuberculosis, intestinal parasitosis, chronic virus B hepatitis, protein-caloric deficiency.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Distribution of HBs antigen in Tananarive (author's transl)].

This survey has been conducted among blood donors and patients with hepatitis, cirrhosis, liver carcinomas and various causes of liver dysfunction or enlargement. The frequency is 5,4 p. 100 among blood donors and 50 p. 100 among cases of hepatitis.

Blood Donors↗
PubMedDate not supplied

[Rheumatoid polyarthritis in Madagascar (author's transl)].

Report of 11 cases of rheumatoid arthritis observed in Malagasy. Frequently, a single joint is concerned at the on-set period and this may raise some questions to differetiate rheumatic fever, gout and osteo-articular tuberculosis, as these three diseases are of high and almost equivalent frequency in the country. Clinical, biological and radiological features are the same as observed in Europe. Evolution is often severe as a consequence of requently delayed diagnosis and difficulties encountered in treatment of out-patients.

Adult↗
PubMedDate not supplied

[Distribution of HBs antigen in Tananarive (author's transl)].

This survey has been conducted among blood donors and patients with hepatitis, cirrhosis, liver carcinomas and various causes of liver dysfunction or enlargement. The frequency is 5,4 p. 100 among blood donors and 50 p. 100 among cases of hepatitis.

Blood Donors↗
PubMedDate not supplied

[Two cases of ankylosing spondylitis in Negroes from Indian Ocean (author's transl)].

Are reported: the first one, observed in Tananarive, on a 26 years old man born in Madagascar, with involvement of sacroiliac articulation and rachis. The second one, observed in Marseille on a 20 years old man who was born in la Reunion, with serious right coxitis and sacroileitis. In the second case, the investigation of HLA B27 antigen was positive. Both cases were probably primitive. A review of literature shows unusualness of ankylosing spondylitis in tropical countries.

Adult↗