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Biomedical subjects

R L Scott

Publications and source records attributed to R L Scott.

At least 91 records · Page 5Linked to original sources
PubMed1980

Aortic dissection manifested as leg ischemia.

The ischemic leg as the only clinical manifestation of an aortic dissection is rare. Without the usual symptoms of an aortic dissection, this diagnosis may easily by overlooked during routine peripheral angiography for the ischemic limb. Three cases are reviewed in which the patient was thought to have a spontaneous peripheral vascular occlusion, but was later found to have an aortic dissection without the usual thoracic or abdominal symptoms. The radiologist should observe carefully for signs of dissection such as fusiform narrowing of a vessel, nonfilling of branches of the aorta, or displacement of the intima into aortic lumen.

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PubMed1978

Influence of dietary potassium on lysine metabolism in the chick.

High levels of dietary cations have been reported to spare the arginine requirement of chicks fed a diet containing excess lysine. The present studies were conducted to determine the nature of this effect, using potassium as the variable cation. The inclusion of 1.8% potassium in a high lysine diet improved growth but did not affect consistently the efficiency of feed utilization, nor did it have a significant effect on arginine metabolism as measured by renal arginase activity, urea excretion or arginine excretion. Lysine catabolism was markedly increased, however. Chicks fed the potassium supplemented diet converted approximately 23% of an oral loading dose of 14C lysine to respiratory 14CO2 over a 6-hour period, in contrast to approximately 9% of the dose in chicks fed the unsupplemented diet containing 0.4% potassium. The activity of hepatic lysine-alpha-ketoglutarate reductase, an initial enzyme in the catabolism of lysine, was increased in response to potassium or arginine supplementation. It is proposed that high levels of potassium or other cations may improve the growth of chicks fed diets containing excess lysine by increasing lysine catabolism. The effect on growth may be mediated primarily by increasing food intake and to a lesser extent by alleviation of the other metabolic manifestation of the lysine-arginine antagonism.

Animals↗
PubMed1975

Involvement of food intake in the lysine-arginine antagonism in chicks.

Studies were conducted to evaluate the involvement of food intake in the lysine-arginine antagonism. Diets were formulated to compensate for the metabolic consequences of excess dietary lysine; induction of renal arginase activity, depression of heptic glycine transamidinase, and urinary losses of arginine. This was accomplished by inclusion of creatine in the basal diet, use of a moderate excess of lysine that did not increase urinary arginine excretion, and addition of the arginase depressors, alpha-aminoisobutyric acid (AIB) and L-threonine, to diets containing excess lysine. When chicks were fed diets containing excess lysine ad libitum, growth and efficiency of arginine retention were reduced. Supplementation of the diets with AIB and threonine markedly reduced the growth depression and restored efficiency of arginine utilization. When chicks were force-fed the diet containing excess lysine, growth was depressed, and body composition was altered. Inclusion of AIB and threonine in the diet containing excess lysine resulted in growth and body composition equivalent to levels of force-fed controls. In a second experiment the basal diet and basal supplemented with AIB and threonine were pair-fed to lysine-supplemented diets containing AIB and threonine. Body weight gains and body composition of all groups were similar. In other experiments, food intake increased within 24 hours (P less than 0.05) and probably within 12 hours (P less than 0.10) after removal of excess lysine from the diet. It is concluded that a portion of the lysine-arginine antagonism is due to a primary effect of lysine on regulation of food intake.

Animals↗
PubMedDate not supplied

Small bowel Procardia XL tablet bezoar mimicking cystic pneumatosis intestinalis.

Procardia XL Extended Release Tablets are being used with increasing frequency in the treatment of angina and hypertension. Bezoar formation, secondary to retained insoluble medication shells, is an important but less well-known complication. We report the first case of a small bowel bezoar due to this unique medication system.

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