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Biomedical subjects

R L Anderson

Publications and source records attributed to R L Anderson.

At least 469 records · Page 26Linked to original sources
PubMed1979

[Microscopically controlled excision of malignant eyelid tumors and subsequent reconstruction (author's transl)].

35 patients, most of whom had recurrent or large malignant eyelid tumors (33 basal cell carcinomas and 2 squamous cell carcinomas), underwent microscopically controlled excision (Mohs' fresh tissue technique). This approach guarantees a complete removal of the tumor, while conserving as much healthy tissue as possible. Short time follow-up studies have shown that plastic reconstruction gave good functional and cosmetic results.

Adult↗
PubMed1978

The blepharocardiac reflex.

The oculocardiac reflex is described as the triad of bradycardia, nausea, and faintness evoked by the stretching of ocular muscles, or by pressure on or within the eyeball. The trigeminal nerve is the afferent limb of this reflex; the efferent limb is the vagus nerve to the heart. This reflex was noted to occur from traction on the levator aponeurosis in five of 36 patients with ptosis, and from traction on the retractors of the lower eyelid in three of 11 patients with entropion. To our knowledge, this is the first documentation of eliciting this reflex by stretching the muscles of the eyelid. Electrocardiogram monitoring for early recognition of these cases, and the availability of an intravenous line with atropine for prompt treatment are strongly recommended. Careful manipulation of the upper and lower eyelid retractors and preoperative atropine therapy may help to reduce the incidence of this reflex.

Aged↗
PubMed1978

Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus. Epidemiologic characteristics.

Nosocomial respiratory tract infection with Acinetobacter calcoaceticus occurs frequently in many hospitals. An outbreak of respiratory tract infections in an intensive care unit provided an opportunity to study clinical and epidemiologic characteristics of such infections. Retrospective studies demonstrated that A. calcoaceticus in sputum was significantly associated with endotracheal intubation (p = 0.03) and continuous positive pressure ventilation (p less than 0.02). After control measures had interrupted the outbreak, a prospective microbiologic investigation demonstrated that one third of the hospital personnel had transient hand colonization with multiple strains of A. calcoaceticus. Pharyngeal, vaginal and rectal carriage was rare. A pulmonary therapist with chronic dermatitis had persistent hand colonization with the epidemic strain, and he contaminated respiratory therapy equipment. Cross contamination of respiratory therapy equipment occurred while in use, but no other inanimate reservoir was demonstrated. Although previous studies have implied that the inanimate hospital environment has unique reservoirs of A. calcoaceticus, these reservoirs were not implicated in this outbreak. Human skin must be considered an important reservoir of A. calcoaceticus.

Acinetobacter↗
PubMed1978

Helminthosporium corneal ulcers.

We studied four cases of Helminthosporium corneal ulcers from four different institutions. One case occurred in an immune-deficient infant, another in a patient three months after removal of a foreign body; the third case occurred in a patient with a corneal dystrophy who was wearing soft contact lenses and using topical corticosteroids; and the fourth occurred in a patient with a history of multiple foreign bodies. Antifungal sensitivities were performed in three cases and showed relatively good sensitivity to available antifungal medications; even though all four patients improved, there was poor correlation between in vitro sensitivities and clinical response.

Adult↗
PubMed1978

A multispecialty approach to the excision and reconstruction of eyelid tumors.

An ongoing study indicates that the Mohs' fresh tissue technique of tumor removal followed by eyelid reconstruction may be the most efficacious management of eyelid malignancies. Forty-seven recurrent, invasive or large eyelid and canthal tumors were excised by this method followed by eyelid reconstruction. The advantages of this approach are (1) a high cure rate, (2) conservation of tissue, (3) reduced operating room time, and (4) maximum utilization of specialty training.

Adult↗
PubMed1978

Labeling of the Plasma Membrane of Pea Cells by a Surface-localized Glucan Synthetase.

When radioactive UDP-glucose is supplied to 1-millimeter-thick slices of pea (Pisum sativum) stem tissue, radioactive glucose becomes incorporated into membrane-bound polysaccharides. Evidence is given that this incorporation does not result from breakdown of UDP-glucose and utilization of the resultant free glucose, and that the incorporation most likely takes place at the cell surface, leading to a specific labeling of the plasma membrane. The properties of the plasma membrane that are indicated by this method of recognition, including the association of K(+)-stimulated ATPase activity with the plasma membrane, resemble properties inferred using other approaches. The membrane-associated polysaccharide product formed from UDP-glucose is largely 1,3-linked glucan, presumably callose, and does not behave as a precursor of cell wall polymers. No substantial amount of cellulose is formed from UDP-glucose in this procedure, even though these cells incorporate free glucose rapidly into cellulose. This synthetase system that uses external UDP-glucose may serve for formation of wound callose.

Journal Article↗
PubMed1978

Microscopically controlled excision of malignant neoplasms on and around eyelids followed by immediate surgical reconstruction.

Mohs' fresh-tissue technique of ablating malignant neoplasms is a highly reliable, yet conservative method of treating cutaneous cancers. Removal of such lesions on eyelids by this technique, followed by immediate reconstruction is a most efficacious way to manage them. Forty-seven cases of recurrent, invasive, or large carcinomas on eyelids and canthi were excised by this method followed by immediate reconstruction. The excisions were done by dermatologists specializing in Mohs' techniques and the reconstruction by an oculoplastic surgeon. The advantages of the combined procedures are: 1) high cure rate, 2) conservation of tissue, 3) reduced operating time, and 4) maximum utilization of specialized competence.

Adult↗
PubMed1978

Typing methods for Proteus rettgeri: comparison of biotype, antibiograms, serotype, and bacteriocin production.

Two hunderd five strains of Proteus rettgeri from epidemic and nonepidemic sources were differentiated by a new biotyping scheme, agglutination in O antisera, antimicrobial resistance patterns, and a new scheme based on bacteriocin production. The P. rettgeri were divided into 10 groups by their fermentation of lactose, sucrose, D-mannitol, and salicin. These groups were then subdivided into 19 biotypes by other biochemical reactions. Bacteriocin production was tested by the cross-streak method. Thirty-four bacteriocin-sensitive indicator strains were evaluated, and 16 were selected for the final scheme and used to type the 205 P. rettgeri, which were divided into 15 bacteriocin types. Serologically, 43% of the P. rettgeri were O42, 13% were untypable, 4% were O15, and 3% each were O33, O64, and O84 in addition to 31 remaining serotypes. Strains of P. rettgeri from known outbreaks contained fewer biotypes, O groups, and bacteriocin types and were more resistant to antimicrobial agents than endemic strains. Strains with common patterns with all four marker systems were frequently associated with outbreaks. A strong correlation between multiple antibiotic resistance and bacteriocin production was shown.

Anti-Bacterial Agents↗
PubMed1978

Failure of disposable domes to prevent septicemia acquired from contaminated pressure transducers.

Between January and June 1976, eight cases of primary bacteremia due to Enterobacter cloacae occurred in patients after open-heart surgery in a hospital in Connecticut. Epidemiologic studies implicated radial arterial catheters as the route of acquistion of E cloacae, and bacteriologic studies confirmed arterial pressure transducers as the sources of bacteria. Prospective studies indicated that the disposable domes from the pressure transducers did not prevent the spread of bacteria from contaminated transducers to the arterial catheters. This is the first report of transducer-acquired bacteremic infections occurring with the use of disposable domes. Although disposable domes may decrease the chances of cross-contamination of circuits for monitoring pressure, they do not, as previously thought, eliminate the risk of bacteremia from this source.

Blood Pressure↗
PubMed1978

Human-mouse mixed lymphocyte cultures.

Conditions for stimulating human lymphocytes with mouse cells are established. The proliferative and cytotoxic responses generated are shown to be specific for antigens coded for in the major histocompatibility locus.

Animals↗
PubMed1977

The levator aponeurosis. Attachments and their clinical significance.

A detailed knowledge of the anatomy of the levator aponeurosis is required for the aponeurotic approach to ptosis. Yet, many misconceptions regarding the insertional attachments of this important structure are found in the literature. The levator aponeurosis inserts via a fan of fibers. The first insertional attachment curves anteriorly around the orbital septum to form the lid crease. Approximately the anterior half of the aponeurosis inserts into pretarsal orbicularis and the overlying subcutaneous tissue. The remaining posterior half inserts firmly on the lower portion of the tarsus.

Blepharoptosis↗