Biomedical subjects
Publications and source records attributed to R King.
This paper illustrates the use of a new tibial jig which facilitates closed Küntscher nailing of the tibia. A brief history of medullary nailing is given, followed by a description of the jig.
In postoperative prostatectomy patients, morphine 2 mg in 10 ml 0.9% saline was given epidurally for pain relief and its effectiveness compared with bupivacaine. The duration of analgesia with morphine was approximately double that with bupivacaine. Significant hypotension occurred in approximately 5% of the patients receiving bupivacaine, but was not seen following morphine. These seem to be important advantages in the use of morphine by this route.
In the first part of this paper, the authors trace "the history of Sardinian migration from the late nineteenth century to the present time. In the second part an attempt is made to test some of the hypothesized causes of migration. Census variables related to these causes and to the spatial pattern of migration are identified and analysed by the technique of stepwise multiple regression." The analysis, based on data for communes, covers the inter-censal period 1961-1971. The emphasis is on out-migration
Explore the source record for details and available documents.
We have histocompatibility (HLA) genotyped 28 families with insulin-dependent diabetics in two or more consecutive generations, usually parent and child. This strategy of ascertainment was used to maximize the likelihood of obtaining a homogeneous type of disease within a family, and an autosomal dominant mode of inheritance. 76 diabetics and 169 nondiabetics were studied in these families. The frequencies of the antigens Dw3 and Dw4, and the genotype Dw3/Dw4 among the diabetics are 59, 68, and 30%, respectively, as compared with 15, 12, and 2% in normal controls, and 43, 41, and 10% in the nondiabetic relatives of the diabetics. Dw2 is present in only one diabetic (4%), as compared with 18% in normal controls and 17% in nondiabetic relatives.HLA haplotype concordance was analyzed for sib pairs in relation to the haplotype shared by the affected parent/child pair, and for the diabetic sib pairs within each sibship. The results failed to reveal deviations in the expected HLA haplotype assortment. Assuming an autosomal dominant mode and several penetrance levels, linkage analysis between the HLA and diabetes was performed. The total lod score is 0.37 for a recombination fraction of 0.29 at 50% penetrance. Although the linkage and concordance analysis results are inconclusive, they seem to be different from those reported by us for families with normal parents and two or more diabetic sibs. Because ascertainment biases may have influenced these results in an unquantifiable manner, it is not certain whether the two types of families are genetically different. However, the marked difference in the lod scores for the 50% penetrant autosomal recessive model between the two types of families is compatible with a genetic dissimilarity between them. The high frequency of the Dw3 and Dw4 antigens, the Dw3/Dw4 genotype, and the decreased frequency of Dw2, however, indicate the existence of two or more important diabetic genetic factors associated with the D region of the HLA in these families.
Explore the source record for details and available documents.
The results of the first six months of treatment of psoriasis with photochemotherapy in the Skin and Cancer Foundation's clinic resulted in 30 out of 53 patients being completely clear of psoriasis lesions, 14 showing progressive improvement (and subsequently clearing), four failures, and five withdrawals. The treatment is not a cure, and requires maintenance therapy. It involves the use of large expensive machines to deliver ultraviolet light, and demands careful supervision and control dosimetry.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A formalism based on the theory of Markov processes and suitable for the analysis of multiple internal motions in macromolecules is presented. Computer calculations of specific motional models for (13)C nuclear magnetic resonance (NMR) relaxation, treated as special cases of the proposed formalism, demonstrate the potential of this approach for discriminating between different motional models on the basis of NMR relaxation data.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.