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Biomedical subjects

R Kerremans

Publications and source records attributed to R Kerremans.

At least 73 records · Page 4Linked to original sources
PubMed1973

Pharmacological characteristics of the non-striated anorectal musculature in cats.

The isolated internal anal sphincter from cats shows a myogenic spontaneous rhythmic activity. Basal tension and frequency of contraction waves from internal anal sphincter strips are inhibited by muscarinic and beta-adrenergic receptors and excited by alpha-adrenergic receptors. Isoprenaline in high doses had an alpha-adrenoceptor-stimulating activity in strips from the internal sphincter. The inhibitory muscarinic receptors may be the final effectors in the anorectal reflex. The relaxing effect of acetylcholine on the internal sphincter was sometimes preceded by a temporary contraction due to the interaction of intermingled longitudinal muscle fibres. Rectal circular muscle strips contain excitatory muscarinic receptors and inhibitory alpha- and beta-adrenergic receptors. The same can be said of the strips from the longitudinal muscle layer at the anal canal and at the rectum.

Acetylcholine↗
PubMed1970

A study in vivo of adrenergic receptors in the rectum and in the internal and sphincter of the cat.

THE SMOOTH MUSCLE SPHINCTERIC ACTIVITY OF THE ANUS IN CATS IS BASED ON TWO DISTINCT MECHANISMS: a typical anal component, characterized by anal slow pressure waves not related to spike potentials in the internal anal sphincter, and an intestinal-like pressure component related to spiking activity in the internal sphincter. Anal slow pressure waves are influenced by the activity of alpha excitatory receptors within the internal sphincter, whereas no conclusive data are available concerning the action of adrenergic beta receptors on this pressure component. Intestinal-like pressure waves and the correlated spiking activity in the internal anal sphincter are influenced by alpha and beta inhibitory adrenergic receptors. The rectal wall of the cat contains alpha and beta adrenergic receptors producing relaxation.

Adrenergic alpha-Agonists↗