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Biomedical subjects

R K Garg

Publications and source records attributed to R K Garg.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Hypophosphatemic rickets: easy to diagnose, difficult to treat.

Hypophosphatemic rickets (HR) has generated a lot of interest in recent times. There is need to recognize this disorder and differentiate it from the more common nutritional rickets because the therapy is different. It is also important to emphasize that a detailed clinical examination with pedigree analysis and easily available biochemical tests are adequate to establish the diagnosis in most cases. This report presents three families with hypophosphatemic rickets. Interestingly, many of these patients had a mixed picture of HR and nutritional rickets. Their important features are described with special emphasis on early initiation of treatment with oral phosphate and stringent monitoring of renal functions to prevent development of irreversible renal insufficiency.

Adolescent↗
PubMedDate not supplied

Antiplatelet and anticoagulant therapy in the prevention of thromboemboli in chronic heart failure.

Thromboembolism is an important complication in patients with heart failure. Several recent clinical trials have established the efficacy of anticoagulant therapy in patients with heart failure and atrial fibrillation. There is renewed interest in examining the role of antiplatelet and anticoagulation therapy in patients with heart failure in sinus rhythm. There is a need to identify patients at risk for thromboembolism in heart failure. However, there are data to suggest that occult thromboembolic events may contribute to disease progression, ischemic events, and sudden cardiac death. This review summarizes the incidence, potential mechanism, and therapeutic approaches for management of thromboembolism in heart failure.

Anticoagulants↗
PubMedDate not supplied

A comparative study of three different test diets in change in plasma total cholesterol in young healthy individuals.

The effect of single dose of three different types of high cholesterol diet on plasma total cholesterol (PTC) in 24 young healthy subjects (male:female = 1:1) aged 15 to 35 years was studied. One group (n1 = 8) was given a butter and milk diet (300 mg cholesterol and 95 g fat). In the first postprandial hour PTC level increased significantly in all but one subject (mean +/- S.D., 4.96 +/- 0.57 m mol/l to 5.61 +/- 0.60 m mol/l, P < 0.005). Second group (n2 = 8) was given a single egg diet (300 mg cholesterol and 6 g fat). In the first hour the PTC level decreased significantly in all but 2 subjects (4.82 +/- 0.58 m mol/l to 4.42 +/- 0.63 m mol/l, P < 0.02). Third group subjects (n2(3) = 8) were given a test diet consisting of crystalline cholesterol with 200 ml milk (1020 mg cholesterol and 14 g fat). The PTC level increased insignificantly. In the first hour in all but 2 subjects (4.94 +/- 0.43 m mol/l to 5.35 +/- 0.88 m mol/l, P > 0.10). In the third postprandial hour the PTC values in all the 3 groups showed a tendency to return to fasting values. Therefore, we conclude that the effect of dietary cholesterol on PTC depends not only on the amount of cholesterol content in the diet, but on the type of diet (cholesterol vehicle) as such and probably also on the fat content of the diet.

Adolescent↗
PubMedDate not supplied

Diabetic retinopathy: a clinical study with special reference to fluorescein angiography.

The present study was conducted on 25 patients with Diabetes Mellitus (DM) having positive indication of diabetic retinopathy on ophthalmoscopic examination. The patients were examined clinically, ophthalmoscopically and with Fluorescein Angiography (FA). It was found that the maximum number of patients with retinopathy were in their 5th and 6th decade and that retinopathy was more common in Non Insulin dependent diabetics (NIDDM) than Insulin dependent Diabetics (IDDM). It was also seen that retinopathy takes longer time to develop in IDDM patients (16.37 years vs 11.7 years). Proliferative diabetic retinopathy was more common with patients having poor glycemic control and in IDDM patients. FA was very helpful in detecting microaneurysms and for exact localization of neovascularization, and other microangiopathic lesions as well as for permanent record.

Adult↗
PubMedDate not supplied

A study of high fat and cholesterol induced lipoprotein changes in first degree relatives of patients of myocardial infarction.

The effect of seven days feeding of high cholesterol and high fat breakfast (HCFB) (79.5 g fat, 1655 mg cholesterol) and its withdrawal was studied on 20 first degree relatives of patients of myocardial infarction (Group A) and 18 controls (Group B). All subjects were young (30 years of age) and had no other risk factor for ischaemic heart disease (IHD). At basal level the first degree relatives had significantly lower values for all lipid fractions except that of HDL. In the control group seven days after giving HCFB a significant rise occurred in all lipid fractions except LDL. The rise of HDL was dominant which led to a significant reduction in LDL/HDL ratio. However, in the first degree relatives no significant change could be observed in any lipid fraction. Seven days after the withdrawal of HCFB there was a significant reduction in all lipid fractions in controls but in first degree relatives the cholesterol level increased significantly from its basal value. However, other lipid fractions showed no significant change, and LDL/HDL ratio remained constant throughout. These different types of behavioural responses to cholesterol could be helpful in identifying high risk hereditarily predisposed persons at early age when basal lipid values are inconclusive.

Adult↗
PubMedDate not supplied

Effect of administration and withdrawal of oral contraceptive pills on serum lipids and lipoproteins.

We studied the effects of oral contraceptive pills (OCP) supplied by the Govt of India in its Family Welfare Campaign, on serum lipid levels of women. The OCP, containing 30 micrograms ethinyl estradiol and 1 mg of norethisterone acetate were administered to the women for six months continuously and serum lipid levels were estimated after three and six months of the treatment. There were no significant changes in serum cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), serum triglycerides and very low density lipoprotein (VLDL). In a simultaneous study we also measured serum lipid levels at 3 and 6 months after withdrawal of the pills in women who had been receiving OCP containing 50 micrograms of ethinyl estradiol and 0.5 mg of one of the progesterones for the past 1 1/2 to 2 years continuously. Only serum LDL level fell significantly (P less than 0.01) on 3 months withdrawal period. It is concluded that 6 months of usage of the OCP marketed by the Govt. of India does not affect the serum lipid profile.

Adult↗