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Biomedical subjects

R Jankowska

Publications and source records attributed to R Jankowska.

At least 55 records · Page 3Linked to original sources
PubMed1981

The effect of polyvaccinum and vaccinum cholericum on the PCA test and degranulation of mast cells in sensitized mice.

The authors studied the effect of bacterial vaccines-Polyvaccinum and Vaccinum cholericum on the production of homocytotropic antibodies and degranulation of mastocytes in sensitized mice. It has been found that stimulation with high antigen doses causes degranulation of intraperitoneal mast cells and addition of polyvaccine results in its marked increase. A 2 h PCA test in mice sensitized with high antigen doses showed dynamic patterns similar in all groups of animals whereas high IgG 1 titres were obtained in animals sensitized with small antigen doses after administration of polyvaccine. Higher PCA titers persisting for 4 weeks were also noted in the 72 h test.

Animals↗
PubMed1980

Effect of isoproterenol and propranolol on the mast cell degranulation and on the passive cutaneous anaphylaxis in mice.

Effect of isoproterenol and propranolol on the production of hemocytotropic antibodies and degranulation of peritoneal mast cells from sensitized mice was studied. It was demonstrated that stimulation with large doses of the antigen caused degranulation of peritoneal mast cells and that additional administration of a beta antagonist propranolol failed to increase the degranulation phenomenon. Marked inhibition in degranulation of mast cells was seen in mice sensitized with large and small doses of antigen after isoproterenol. In 2h PCA test in animals immunized with large doses of the antigen a higher activity of PCA reaction illustrating the concentration of IgG1 antibodies was noted. With higher doses of the antigen and propranolol the titers of the antibodies were markedly higher. The inhibiting effect of isoprenaline on the passive cutaneous anaphylaxis was observed only in the 72 h-test, mostly in the group of mice immunized with small doses of the antigen.

Animals↗
PubMed1980

Sorption of cholesterol and other bile components on ion-exchangers in vitro, and their influence on the cholesterol level in human serum in vivo.

The sorption of bile acids, bilirubin, bilirubin glucuronates and cholesterol on ion-exchange resin is described. After some successful attempts of sorption of these substances from human and animal bile in vitro, this exchanger has been used in human therapy. Positive results obtained showed the usefulness of the method. The purpose of the experiments was to study the usefulness of ion-exchangers for sorption of bile components of bile acids, bilirubin, bilirubin glucuronates and cholesterol. First sorption was carried out on human and animal bile, on Zerolit-FS-ip, in cycles (OH-) and (Cl-), by passing through glass columns downwards and some of them by mixing the bile with ion-exchange resin. Zerolit FS-ip is an organic sorbent, a scavenger, a strongly basic macroporous, anion exchanger. Positive results of these sorptions indicated the possibility of using this method in therapy of disturbed lipid conditions.

Adult↗
PubMedDate not supplied

Modulation of adhesion and chemotaxis of human neutrophils by cortisol, transforming growth factor-beta and antiinflammatory drugs.

Neutrophils are the first cells that accumulate in response to stimuli from the arising inflammation site. We have studied the influence of commonly used antiinflammatory (acetylsalicylic acid) and immunosuppressive (cyclosporin A, methotrexate) drugs and endogenous substances of antiinflammatory activity (cortisol, transforming growth factor-beta; TGF-beta) on the interdependent phenomena of cell motility and adhesion. Neutrophils from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic-bound monoclonal antibodies to CD11a/CD18, CD11c/ CD18 and CD44 was determined. We have found that the studied drugs significantly lowered adhesion (by 40%) of neutrophils to the ligands. Simultaneously, cell motility was investigated according to the Boyden method. We found a significant dose-dependent increase in the motility of this cells in a range comparable to conventional chemoattractants for neutrophils. These data indicate that simultaneous enhancement of motility and reduction of adhesion might be a common pathway for the mechanisms of action of the most common anti-inflammatory drugs.

Adult↗
PubMedDate not supplied

[Circulating immunologic complexes in blood sera of bronchial asthma patients treated with attenuated vaccine].

The study included 20 patients (8 males and 12 females) with non-atopic bronchial asthma treated with attenuated vaccines. Circulating immune complexes were assayed with two methods prior to and after the treatment of each patient. No increase in serum circulating immune complexes was produced after the treatment. Clinical improvement was noted in 75% of treated patients. Circulating immune complexes were detected in the blood serum of three patients treated without an effect.

Adult↗