Adaptation to the inhibitory effect of carbon monoxide inhalation on drug metabolism.
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Biomedical subjects
Publications and source records attributed to R J Rubin.
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Phthalate ester plasticizers were found to be extracted by blood from plastic tubing and from plastic bags used for blood storage. One such plasticizer was metabolized by the isolated perfused rat liver while another was found to be accumulated in the liver unchanged. In addition, this latter plasticizer was identified in samples of human tissue taken from patients who had received transfusions of blood stored in plastic bags. The biological implications of these observations are considered.
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Injury to the ureters is a serious complication of colonic and rectal surgery. The experience of the authors with routine use of ureteral catheters to minimize this complication is reviewed. It was found that there are minimal complications associated with their use. Injuries to the ureters were not completely avoided. However, unrecognized injuries (except ischemia) did not occur.
Three hundred and ninety-three patients who had anal fissures were followed continuously for approximately five years. More than 44 per cent of them were cured nonsurgically within a four-to-eight-week period. There was an 8 per cent complication rate, consisting of abscesses and fistulas, necessitating surgical treatment. The recurrence rate following healing was 27 per cent, but a third of these patients had recurrent fistulas that healed in response to further conservative treatment. The authors feel that conservative treatment of anal fissure is justified unless there is advanced anal stenosis.
Lateral internal sphincterotomy proved to be effective in 99 per cent of the 418 procedures in which it was performed. The complication rate of 5 per cent was an improvement over most of the rates reported in the medical literature and over our previous experience with posterior sphincterotomy and anoplasty. Anal wounds and fissures healed faster than with previous procedures. It is encouraging that this simple and rapid procedure has such great efficacy with a minimum of complications.