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Biomedical subjects

R J Jones

Publications and source records attributed to R J Jones.

At least 217 records · Page 12Linked to original sources
PubMed1975

Detection of endotoxins with the Limulus test in burned and unburned mice infected with different species of gram-negative bacteria.

The Limulus test detected endotoxins in the plasma of burned and unburned mice infected with different species of gram-negative bacteria produced different amounts of endotoxin in the plasma of infected mice. Plasma from mice given lethal infections showed very high concentrations of endotoxin. Low concentrations of endotoxin in the plasma were tolerated by mice but high concentrations were invariably fatal. A polyvalent pseudomonas vaccine reduced endotoxin in the plasma of mice given lethal infections of Pseudomonas aeruginosa.

Administration, Topical↗
PubMed1975

Protective properties and haemagglutinins in serum from humans and in serum from mice injected with a new polyvalent Pseudomonas vaccine.

Mice given single injections of a polyvalent pseudomonas vaccine produced anti-pseudomonas haemagglutinins against the 16 component immunogens of the multivalent vaccine. Mice passively immunized with sera from vaccinated mice were protected against lethal challenge by 8/10 strains of Ps. aeruginosa of homologous serotype. Protection by the serum was inversely proportional to the virulence of the challenge strains. Anti-pseudomonas haemagglutinins were always present in sera which passively protected mice against pseudomonas infection. Low levels of anti-pseudomonas haemagglutinins were present in some sera which failed to passively immunize mice against pseudomonas infection. Anti-pseudomonas haemagglutinins and antibodies involved in passive protection were mainly in the IgM fractions of mouse serum. Control human sera contained anti-pseudomonas haemagglutinins against most serotypes of Ps. aeruginosa. Sera from patients with burns contained high levels of anti-pseudomonas haemagglutinins against some but not all serotypes of Ps. aeruginosa. Sera from both controls and patients with burns passively protected mice against pseudomonas infection.

Agglutinins↗
PubMed1974

5-Bromouridylyl-(3-5)-adenosine isolated from 5-bromouracil-induced filaments of Escherichia coli.

A dinucleoside monophosphate was isolated from 5-bromouracil-induced filaments of a thymine auxotroph of Escherichia coli K-12. The dinucleoside monophosphate was fractioned from a [(14)C]5-bromouracil-labeled perchloric acid extract using Dowex-1-formate ion-exchange chromatography. Sephadex chromatography revealed its molecular weight to be 710. Snake venom phosphodiesterase digest of the dinucleoside monophosphate yielded [(14)C]5-bromouridine and adenosine 5'-monophosphate. The presence of [(14)C]5-bromouracil in bacterial ribonucleic acid indicates that ribonucleic acid, which had incorporated 5-bromouracil, was the probable source of this dinucleoside monophosphate, 5-bromouridylyl-(3' --> 5')-adenosine.

Adenosine↗
PubMed1973

An experimental application of a social reinforcement approach to the problem of job-finding.

The current conception of the employment process is that positions become available, are publicized, and are filled by the most qualified job seekers. An alternative conception is proposed that social factors play a major role in the process and that job finding can be analyzed as an exchange of social reinforcers in which the first behavioral step is to locate job openings. A questionnaire survey of 120 jobs found that two-thirds of the job leads came from friends or relatives who: (1) usually knew of a specific opening (63%); (2) were themselves employed by the hiring firm (71%); and (3) actively influenced the hiring process (53%). An experimental evaluation was made of an "Information-Reward" advertisement procedure for motivating community residents to report unpublicized openings. It was found that the Information-Reward procedure produced 10 times as many job leads and eight times as many placements as a noreward control advertisement. These findings represent a first step toward a much needed technology of job finding that is based on experimental evidence and support the notion that the employment process depends on factors unrelated to work skills.

Journal Article↗
PubMed1972

Specificity of early protective responses induced by pseudomonas vaccines.

A single inoculation of pseudomonas vaccine protected mice against a 1 LD 100 challenge by nine different serotypes of Pseudomonas aeruginosa, 4 days after vaccination. Three inoculations of the same vaccine, given on consecutive days, protected mice for a longer time, against challenge by a wide range of Ps. aeruginosa serotypes, than the single inoculation of vaccine. The amount of vaccine inoculated only marginally influenced the non-specific response. F1 vaccines from eight serotypes of Ps. aeruginosa each induced protection against a different range of serotypes.

Animals↗