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Biomedical subjects

R J Jones

Publications and source records attributed to R J Jones.

At least 181 records · Page 10Linked to original sources
PubMed1982

Coronary artery revascularization: reoperations performed on 124 consecutive patients.

The results of 124 coronary reoperations performed during a 9-year period are reviewed, with the causes of failure of the initial operations and technical considerations in the reoperation procedures. The reoperative experience provided considerable insight as to why an initial revascularization might be unsuccessful. The three basic mechanisms which appeared to lead to recurrence of symptoms or late infarction following coronary bypass were (1) inadequate initial revascularization, (2) graft failure (occlusion or stenosis), and (3) progression of disease in the native circulation. Means of prevention and surgical techniques are reviewed in detail.

Journal Article↗
PubMed1981

Migraine: a platelet disorder.

The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from controls. Platelet 5-hydroxytryptamine release within three days of a migraine attack was significantly less than that measured during a migraine-free interval. Platelets from migraine patients differ significantly in their behaviour from normal platelets, and these differences can explain the onset and recurrence of attacks.

Adenine Nucleotides↗
PubMed1980

Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients.

In a controlled trial burn patients at risk of Pseudomonas aeruginosa septicaemia were passively immunised with an immunoglobulin prepared from plasma from healthy human volunteers vaccinated with a polyvalent pseudomonas vaccine; passively immunised and vaccinated; or only vaccinated. In children the mortality was lowest in those passively immunised (0%, 0/18); it was 21% (9/42) in controls. In adults the mortality rate of those receiving immunoglobulin or vaccine was 10% (3/30) or 8.3% (5/60), respectively, compared with 36% (22/61) in controls. Combined vaccine and immunoglobulin treatment gave rather less protection (mortality 13.6%, 3/22) than vaccine alone. Pseudomonas infection of burns was less common in patients who received immunoglobulin than in vaccinated or control patients.

Adolescent↗