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Biomedical subjects

R Hicks

Publications and source records attributed to R Hicks.

At least 109 records · Page 6Linked to original sources
PubMed1981

An alternative model for the psychiatric clerkship.

Clinical clerkships in psychiatry are traditionally based on in-patient services and thus limit student exposure in the main to seriously ill psychiatric patients. Such clerkships have been criticized as having questionable relevance to the primary care careers which are increasingly selected by medical students. The present paper describes a clerkship in which half the students are taught on a traditional in-patient service while half go to a special medical-psychiatric unit. In the latter situation, medical and psychiatric patients are housed together and consultation-liaison experiences play a prominent part in the students' experience. Some comparative data are presented which suggest that the two clerkship experiences are equally satisfactory to the students. It is concluded that a psychiatric clerkship utilizing settings and experiences which are close in character to primary care is educationally feasible.

Education, Medical, Undergraduate↗
PubMed1979

An investigation of the experimental induction of hypersensitivity in the guinea pig by material containing chromium, nickel and cobalt from arc welding fumes.

Sensitization of guinea pigs by chromium, cobalt and nickel was compared by four methods. The most effective was the maximization test of Magnusson and Kligman. Sensitizing properties of particles from fumes of either manual metal arc (MMA) or metal inert gas welding were demonstrated. Potent sensitization was attributed to chromium.

Animals↗
PubMed1978

Reflex neurovascular dystrophy in childhood.

Reflex neurovascular dystrophy has rarely been recognized in children. During the past eight years we have observed 24 instances of RND in 23 children. Lower extremity involvement was manifested in 20 of them and upper extremity in four. The major complaint was pain; swelling and vasomotor instability were prominent, and exquisite tenderness was characteristic. Chronic trophic changes were not observed. Antecedent illness or trauma could be related to the RND in less than half of the children, but personality factors appeared contributory to the development of RND in most children. Physical therapy was the principal form of treatment; therapy with a corticosteroid or by sympathetic blockade was not employed. Reduction in the evidences of disease, including improvement in function, were present in all children at the termination of therapy; improvement was maintained in all but one child after a mean period of 2.4 years. The excellent response to conservative therapy suggests that RND may be a more benign condition in children than in adults.

Adolescent↗
PubMed1976

Evaluation of a Coulter Chemistry Unit.

Seventeen channels of a Coulter Chemistry Unit were evaluated. The evaluation included within-run and day-to-day precision, recovery, dilution, carryover and interference studies; as well as correlation studies between the Coulter Chemistry Unit and the procedures currently used in the author's laboratory. Criteria for acceptance of a procedure are outlined. Five channels of the particular instrument studied were found acceptable by the author's criteria, six channels had correctable defects, and six channels had either reagent or instrumentation deficiencies.

Autoanalysis↗
PubMed1975

Core cooling after hypoxia and ischaemia.

Two patients sustained severe circulatory inadequacy before and during thoracotomy for coronary surgery. Both patients were promptly cote cooled to between 20 degrees and 25 degrees C. After coronary surgery, each patient was rewarmed and the operation was terminated uneventfully in each case, No important cerebral deficit was apparent despite periods of circulatory insufficiency and arrest which were well beyond the usually accepted limits. It is suggested that prompt core cooling may exert a protective effect in this context.

Adult↗
PubMed1975

The possible occurrence of endogenous anti-inflammatory substances in the blood of injured rats.

1 Using the carrageenin rat paw oedema test as an assay, an attempt has been made to confirm the presence of anti-inflammatory activity in the blood of rats with a chronic inflammatory lesion induced by a polyester sponge, and to relate such activity to the systemic anti-inflammatory effect exerted in situ by the lesion. In addition, plasma from rats given acetic acid intraperitoneally has been examined for anti-inflammatory properties. 2 The activity of serum obtained from sponge-bearing adrenalectomized Wistar rats did not differ significantly from that obtained from animals without implants. Furthermore, implanted sponges exerted no systemic anti-inflammatory effect. 3 Similar experiments were performed in sponge-bearing adrenalectomized Sprague-Dawley rats, plasma instead of serum being examined for anti-inflammatory activity. The plasma removed from such animals possessed no anti-inflammatory activity, whilst implanted sponges exerted a small, yet significant, systemic inhibitory effect. 4 When the irritancy of sponge implants was augmented with croton oil, more marked systemic anti-inflammatory effects were observed. However, the plasma obtained from rats injured in this manner exerted no anti-inflammatory effect. 5 No anti-inflammatory activity could be detected in plasma samples obtained from rats treated with doses of acetic acid capable of producing pronounced systemic anti-inflammatory effects. 6 It was concluded that the induction of these inflammatory lesions in rats does not appear to lead to a detectable release of endogenous anti-inflammatory substances into the circulation.

Acetates↗
PubMed1972

The nature of adrenergic mechanisms involved in anaphylatoxin activity in the guinea-pig.

1. Evidence is presented to elucidate the nature of the adrenergic mechanisms involved in responses of the guinea-pig to anaphylatoxin (AT).2. Investigation by means of adrenalectomy, adrenergic neurone blockade, alpha- and beta- adrenoceptor blockade and exclusion of autonomic reflexes, revealed that the adrenergic mechanisms provoked included catecholamine release from the adrenal medulla, sympathetic reflex activity, stimulation of adrenergic neurones and alpha- and beta-adrenoceptor activity.3. The cardiovascular effects of AT, mediated by histamine release, were largely attributable to adrenal medullary and adrenergic neuronal mechanisms. These mechanisms also exerted a restraint on the predominantly histamine mediated bronchoconstrictor effect of AT.4. The cardiovascular effects of AT activity, not attributable to histamine release, were also probably associated with catecholamine release. However, the bronchoconstrictor component of this AT activity was not significantly affected by guanethidine, and it would, therefore, appear that neuronal bronchodilator mechanisms did not exert a restraint upon this aspect of AT activity.5. These findings are generally compatible with previous work showing that adrenergic mechanisms operate during AT-induced responses. In contrast to previous reports, however, the adrenergic activity was predominantly associated with the effects of released histamine.

Adrenalectomy↗