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Biomedical subjects

R Haupt

Publications and source records attributed to R Haupt.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Liver diagnostics].

Prerequisite of a scientific and rational liver diagnostics is the knowledge of the physician of function and structure of the liver. The laboratory demand should always be an accomplishment of the physician and should be performed only upon such a scale that it is also followed by therapeutic consequences and/or consequences concerning the expert's opinion. The biochemical blood analysis gives information about the size of the injury to the parenchyma and about the disturbance of the various partial functions of the liver. In this case is to be taken into consideration that biochemical and histological parameters are no concurrent, but supplementing diagnostic methods. A progress in liver diagnostics is the use of the isoenzymes of the aspartate aminotransferase and the lactate dehydrogenase as well as of the enzymes of the metabolism of the connective tissue. With the entering into selected parameters of the liver diagnostics possibilities to the establishment of the disturbed liver metabolism by means of markers are shown and at the same time recommendations for the praxis of the liver diagnostics are derived.

Clinical Enzyme Tests↗
PubMed1985

[Histomorphologic picture of chronic non-A, non-B hepatitis].

Basing on several international studies on the light microscopic pattern of acute non-A, non-B hepatitis we tried to discover the histological criteria of its chronic course by means of a detailed analysis of 181 liver biopsies of 94 patients suffering from chronic non-A, non-B hepatitis (a homogeneous group without competing noxious agents). In accordance with the relevant literature we found a rate of chronic courses of about 60% with chronic persistent hepatitis (2/3) and chronic lobular hepatitis (1/3) predominating. A transition into liver cirrhosis was not stated. As changes typical of the chronic non-A, non-B hepatitis cell ballooning (89%), changes of cell nuclei (88%), eosinophilic changes of cytoplasm (73%), focal sinusoidal cell activation (92%) and microvesicular steatosis (59%) were ascertained with the chronological analysis showing that there were no changes of these criteria up to the 6th year of disease. Its cause is seen in an incomplete elimination of the hepatitis viruses as a result of inefficient immune defence.

Adult↗
PubMed1985

[Clinical and morphologic aspects of balloon catheter nephrostomy].

During 23 years in the County Hospitel St. Georg Leipzig 500 nephrostomies were performed. A definitive balloon catheter nephrostomy was performed 58 times. Exclusively the open transparenchymatous establishment was carried out. If no malignant basic disease shortens the survival time, the renal fistulae are tolerated for many years without greater restriction of the renal function. The longest time of observation of a fistulated solitary kidney is about 17 years. The complication rate is small and the psychic stress of the patient as well as the quality of life obtained are tolerable. A preoperative intensive talk with the patient with adequate explanation and alternative demonstration is necessary in every case. An epithelial lining of the channel of the fistula does not take place even after years. The squamous cell epithelium of the external skin and the urothelium of the renal calyces grow only a few centimeters into the fistula. This is lined by inflammatory granulation tissue.

Catheterization↗
PubMed1985

[Regional metastasis of bronchial cancer and therapeutic consequences. A contribution to the problem of the prognostic effectiveness of lymphadenectomy].

In 1003 patients suffering from bronchial carcinoma the authors examined the type of lymph node spread. Radical lymph nodeectomy takes 30 to 60 minutes more without increasing the survival time, only the rate of regional metastases is diminished. The fate of the patient is dependent on the spread of haemotogenous micrometastases. According to the authors opinion simple extirpation of the regional lymph nodes as an en-bloc-procedure will be sufficient.

Adenocarcinoma↗
PubMed1984

[Hepatic coma in fulminating viral hepatitis--treatment results in 1981 in a district hospital].

n the basis of clinical case reports on liver disintegration comata in foudroyant virus hepatitis the coma therapy was explained which was performed in the clinic for infectious and tropic diseases of the County Hospital St. Georg Leipzig in 1981 and this therapy was compared with the possibilities mentioned in literature. The aim of the article was to determine the present position of a county hospital in the great number of forms of therapy proposed. The basic therapy aimed at the reduction of neurotoxic protein metabolites and the application of intensive-medical therapeutic methods in interdisciplinary cooperation of internal specialist, specialist in dialysis and haemostaseologist are valuated as successful. The combined haemoperfusion/haemodialysis--two out of three patients treated survived--as a constituent of the present concept of therapy is assessed positively.

Adult↗
PubMed1984

[Small intestinal absorption in cancer patients--basis for enteral feeding therapy in oncology].

A deteriorating nutritional condition combined with the loss of body mass is one of the most noticeable symptoms of cancer. In order to answer the question to what extent absorption disorders in the small intestine are responsible for the malnutrition which develops, we studied 54 oncologic patients using modified D-xylose absorption tests. After the oral and intravenous administration of 10 g D-xylose at different times, the degree of absorption dependent on time was determined on the basis of a biophysical model. When accompanied by general nonspecific tumor symptoms, the frequency of absorption restrictions was increased. An established relation was found between the extent of small intestinal absorption, on the one hand, and the degree of spreading (staging) and the degree of histological differentiation of the carcinoma, on the other hand. Enteral absorption disorders represent a partial cause for the development of malnutrition in cancer patients and must be viewed as a result of a metabolic situation which is distinctly catabolic.

Adult↗
PubMed1984

[Surgical treatment of small-cell bronchial carcinoma].

The analysis of 284 resected small-cell bronchial cancers from 4 Lung clinics has shown that these represent 11% of all resected lung cancers. The 5-year survival rate was 24%. The male-to-female ratio was 9.5: 1. Two-thirds were detected by X-ray mass screening. The majority of them (60%) were peripheral tumors. 50% of the patients had a stage Ia cancer and showed a 5-year survival of 40%! This result speaks for the primary surgical therapy even for stage I small-cell bronchial cancers, and for a 6-month screening interval of the respective risk groups. Patients with stage II or III cancers showed a 5-year survival rate of only 10%. In such cases postoperative adjuvant chemotherapy should be carried out. But such a therapy seems to be little effective in stage Ia patients.

Antineoplastic Agents↗
PubMed1984

[Morphological studies on Jensen sarcoma in the rat under artificial short-term hyperglycemia].

Possible actions of artificial short-time hyperglycaemia, which is tested as an adjunctive measure in various therapeutical concepts of tumours (for instance in combination with oncolytic apathogenic Clostridia), were checked by histomorphological investigations in Jensen sarcoma of rats. The glucose-induced hyperglycaemia caused a considerable increase of the extend of necrosis in the whole tumour. These morphological findings gave evidence of the high tumour selectivity of the provable effects of artificial short-time hyperglycaemia.

Animals↗
PubMed1983

[Effect of a bicycle ergometry training program in the acute phase of viral hepatitis on its late prognosis].

37 patients with clinically and histologically ascertained acute virus hepatitis (51% virus hepatitis B) underwent a bicycle-ergometric load a short time after admission to hospital and 17 of them were subsequently submitted to a training from twice a day to 30 minutes with 70% of the submaximal steady state effect. After their discharge from hospital all patients were repeatedly examined in the outpatient department for on an average 2.7 years; 20 patients (8 in the load group, 12 in the comparative group) were submitted to a liver biopsy on an average after one year. In 11 of the other patients the result of a histological examination of the liver from the end of the clinical treatment was present. The comparison of the training group and the control group showed nearly the same percentage of cures for the two groups as well as no transitions into chronic hepatitis in the training group. Also clinical and biochemical relapses did not appear in the load group. In a follow-up observation up to five years in the training group did not appear any disadvantage concerning the complete cure of virus hepatitis so that we apparently do not fear any negative sequels of physical activity in the acute phase of virus hepatitis. A forced immobilisation of the body--after proved ineffectiveness of diet and medicamentous treatment last support of the therapeutic regime--thus seems no more be indicated, since it is also accompanied by impairing reduction of the bodily function.

Acute Disease↗