Search PubMed⌕ Search

Biomedical subjects

R Hartung

Publications and source records attributed to R Hartung.

At least 163 records · Page 9Linked to original sources
PubMed1979

[Kinetics of the growth of Ca oxalate crystals from supersaturated solutions].

Several factors influencing the nucleation and growth of Ca-oxalate crystals from metastable and instable solutions were studied in some detail. Factors of interest were the absolute concentration of calcium respectively oxalate, the quotient oxalate/calcium, repeated additions of calcium and/or oxalate, the presence or absence of crystal seeds, the agitation respectively stagnation of the metastable Ca-oxalate solution, the duration of crystallization, etc. The striking findings are the eminent role of oxalate in the formation of big crystals and crystal aggregates, the distinct inhibition of crystal growth at higher and very high calcium concentrations, as well as the substantial crystal enlargement at the presistent oxalate load.

Calcium Oxalate↗
PubMed1979

[Transsexualism: indication and surgical treatment].

After the diagnosis of transsexuality is well definated and recognized in most western countries, the surgical transformation of the genital area is performed. Before surgical treatment an exact psychiatric clarification is absolutely essential. The operation is the last part of a long treatment. The surgical result in the more common female transsexual is quite reasonable. The treatment of the fewer male transsexuals is not solved completely, especially the reliable techniques for penis reconstructions are not very sufficient.

Castration↗
PubMed1979

[Urethral strictures following transurethral instrumentation: causes, prevention, results (author's transl)].

The paper discusses the multiple causes of developing urethral stricture after transurethral instrumentation. Methods are presented how these causes may be avoided with specially by on internal urethrotomy. 1660 cases of TUR show, that in 12,1% an internal urethrotomy was necessary to introduce a 24 F instrument. The frequency--distribution of the localisation of the sites of internal urethrotomy is presented. Follow-up shows that postoperative strictures have developed in 5,1% in cases without internal urethrotomy and only in 2,6% in cases where internal urethrotomy was performed before introducing the instrument for TUR.

Cystoscopy↗
PubMed1978

[Quantitative determination of phosphates in urinary calculi and their matrices].

The question whether the phosphate participates actively in the calculogenesis or whether it is only an accidental enclosure in the stone material can, in our opinion, only be answered by the quantitative determination of phosphorus in the stone material resp. in the organic stone matrix. The high enrichment of phosphorus in the stone material, in comparison with the urine, as well as its additional significant enrichment in the stone matrix, compared with the (crystalline) stone material, both deduced from our analytical data, nearly exclude a passive role of the phosphate in the calculogenesis. On the basis of our investigation we suppose that the phosphate crystalluriae, occurring spontaneously or induced, at moderate pH-values of urine, especially by Ca-oxalate, sometimes by urate crystalluriae, contribute to the crystal "density" in the urine, the sufficient crystal "density" being one of the preconditions for the formation of compact crystal aggregates; the other precondition is the presence of the reactive organic cement substance in a sufficient concentration. This active crystal agglomerating component is represented, in our conception, by partially hemolysed blood cells resp. by the cholesterol of their damaged membranes.

Humans↗
PubMed1978

[Factors which influence the size of calcium oxalat crystals during their formation from saturated solutions].

The nucleation and growth of Ca-oxalate crystals from metastable and instable solutions was studied in some detail to find out the dependence of the crystal size on the absolute calcium resp. oxalate concentration, further on their molar ratio, on the presence resp. absence of crystal seeds, on the agitation resp. stagnation of the Ca-oxalate solution, on the duration of crystallization and on the renewing of the Ca-oxalate containing supernatant, thus simulating a prolonged (dietary) oxalate load in vivo. The most important findings are the clear inhibition of crystal growth at higher and very high calcium concentrations (in contrary to the unhindered crystal enlargement at high oxalate concentrations), further the eminent role of the oxalate in the formation of big crystals and crystal aggregates, as well as the substantial crystal enlargement at the persistent oxalate load.

Calcium Oxalate↗
PubMed1978

[Correlations between the metastable solutions of calculus-forming salts and crystals from coexistent insoluble urinary components].

The correlations between the individual stone-forming systems, expecially the induction of heterogeneous crystallization from metastable solutions of one stone-forming system by preformed crystals of the other stone-forming system, were measured semiquantitatively by the Coulter-Counter-Size Distribution Analyzer technique. It has been found out that Ca-oxalate crystals may represent potent triggers and accelerators of the phosphate precipitation from metastable Ca-phosphate solutions. The importance of this phenomenon could be attributed especially to the induction of crystal rich phosphate crystalluria at moderate pH values (6,5--6,8) by the preceding Ca-oxalate crystalluria (,,starter "resp." primer "crystalluria). The favouring, promoting influence of uric acid on the stone formation and growth of Ca-oxalate crystals could be observed with the same experiments under changed conditions. This mechanism could be of some importance in the case when Ca-oxalate precipitates from the urine, saturated by uric acid, at low pH values (5,0--6,0). Uric acid resp. sodium urate crystals showed a moderate by clear favouring effect on the formation of Ca-phosphate crystals from metastable solutions. The influence of Ca-phosphate crystals upon the growth of Ca-oxalate crystals proved to be very limited.

Calcium Oxalate↗
PubMed1977

[Quantitative assessment of drug-induced prophylaxis of postoperative thromboembolism. Comparison of frequencies of deep vein thrombosis and pulmonary embolism using acetylsalicylic-acid, dextran, dihydroergotamine, low-dose heparin and the fixed combination of heparin and dihydroergotamine (author's transl)].

2136 patients in general surgery, gynaecology and urology were investigated by the 125I-fibrinogen-uptake-test for detection of postoperative deep vein thrombosis (DVT). They received at random one of low-dose heparin, dihydroergotamine, the fixed combination of both drugs (Heparin-Dihydergot), low molecular weight dextran and acetylsalicylic-acid (ASS). When DVT was detected repeated lung perfusion scintigraphies were carried out for diagnosis of embolic pulmonary perfusion defects. Results demonstrate the outstanding effect of Heparin-Dihydergot, which is not only 2-3 times better than the anti-thrombotic standard low-dose heparin but also eliminates almost completely the risk of postoperative embolism. The preventive efficacy of ASS and dextran must be considered to be poor and not comparable to that obtained when using heparin, dihydroergotamine or the combination. Now Heparin-Dihydergot is the new standard with which all prophylactic procedures should be compared.

Adult↗
PubMed1976

[Value and relevance of metabolic function tests in the diagnosis of primary hyperparathyroidism (author's transl)].

Calcium, phosphate and alcaline phosphatase levels were determined in the serum of 29 patients with suspected primary hyperparathyroidism. Phosphate clearance according to Kyle, 24 hours urine hydroxyproline excretion during collagen free diet, the excretion of cAMP in the 24 h urine during calcium restricted diet were examined with regard to the diagnostic value and relevance as compared to the consumption of laboratory and staff time. The elevation of the serum calcium levels are not specific and only of minor diagnostic value. It has been found that the highest diagnostic value is given by the Kyle-test using 15 mg Ca ions/kg body weight. No false positive results were recorded. The excretion of hydroxyproline and calcium are only of limited value. Serum alcaline phosphatase and cAMP excretion have no diagnostic significance whereas concentration of serum phosphate may have some value.

Alkaline Phosphatase↗
PubMed1976

[The bladder-stone punch--a new principle of visual lithotripsy (author's transl)].

Description of a bladder-stone lithotriptor which works similarly to a punch resectoscope. This 24 French instrument can be used in simultaneously with electrohydraulic lithotripsy (Urat I), i.e., stones of the size of a cherry can be simply punched, while all larger stones may be destroyed first by electrohydraulic lithotripsy and then cut into smaller pieces for removal with the punch. The instrument, with irrigation qualities and a sight like a resectoscope, allows a quick operation, so that lithotripsy and TUR of the prostate may be performed opportunely.

Cystoscopy↗
PubMed1976

[The controlled TUR: a new method for the measurement of intraoperative blood-loss during TUR (author's transl)].

The measurement of intraoperative blood-loss during TUR is concerned as a compulsory procedure for this kind of operation. After testing so far known methods for measuring blood-volume in blood-water-mixtures and demonstrating greater disadvantages of these methods, we developed a new photometer, which allows an immediate and exact estimation of the blood-loss. We compared this new method with other also exact but more complicated methods, had laboratory tests and tests in the daily operative routine and excluded possible mistakes.

Aged↗
PubMed1975

[The significance of uric acid in calcium oxalate nephrolithiasis].

The findings of serum diagnosis (urea nitrogen, creatinine, uric acid, calcium, phosphorus) in 247 patients with oxalate stone were divided according to sex, and the excretion of uric acid, calcium and phosphorus was estimated. Compared with the control group, the levels of serum uric acid and serum calcium were statistically significantly raised, the mean level not exceeding the normal range. The serum uric acid level was 25% above the normal range in men and 20% above in women, and in the upper range of normal in one third of each, men and women. The excretion of uric acid in women exceeds the normal level in 32% of cases and in 40% of the men, sometimes considerably. The connection between pathological uric acid levels in the serum and urine and the development of oxalate stone, as well as the therapeutic consequences are discussed.

Adult↗
PubMed1975

Lead. Possible toxicity in urban vs rural rats.

The degree of lead poisoning in wild rats from two environments has been studied. Wild rats captured in an urban area had markedly elevated tissue lead compared with values in rural rats. This elevation may have been caused by differences in factors affecting absorption of ingested lead or an elevated respiratory exposure to airborne lead, or both, and lead in precipitated dust. Changes in several biologic indexes (depression of delta-amino levulinic acid dehydratase in kidney and red blood cells, presence of renal intranuclear inclusion bodies, and increased kidney weight) confirmed lead-poisoning in urban rats.

Adult↗