[Normal ranges in uroflowmetry (author's transl)].
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Biomedical subjects
Publications and source records attributed to R Hartung.
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Goldfish (Carassius auratus) were exposed to outboard exhaust products in water or to toluene (a constituent of outboard motor exhaust water) via a continuous flow bioassay dosing apparatus. Various physiologic and pathologic changes were noted. In the blood a consistent decrease (p less than 0.05) in the partial pressure of oxygen, a significant increase (p less than 0.05) in the partial pressures of carbon dioxide, and significant decreases (p less than 0.05) in pH and oxygen saturation were found in many of the blood gas experiments. Laboratory experiments also indicated that these fish are capable of metabolizing toluene to hippuric acid (p less than 0.05). Exposure up to 30 days to these exhaust products produced gross and microscopic lesions in the high-, intermediate-, and low-dose fish. Grossly, livers were smaller and pale; intestines were empty of ingesta and feces; and gills were coated excessively with mucus. Microscopically, the livers of the exposed fish had a decreased cytoplasmic:nuclear ratio, gill filaments were fused, and some kidneys had tubular vacuolization.