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Biomedical subjects

R Happle

Publications and source records attributed to R Happle.

At least 343 records · Page 19Linked to original sources
PubMed1979

Roentgenographic and clinical signs in yellow nail syndrome.

The yellow nail syndrome is a rare condition consisting of thickened opaque yellow nails, lymphedema and respiratory symptoms such as bronchitis or pleural effusions. In a 25-year-old woman, presenting all clinical signs of this syndrome, lymphangiography revealed impaired lymphdrainage of both legs. Both, number and size of the lymph vessels and regional lymph nodes were found to be reduced and several extravasations of the contrast medium were noted. Lymphangiography may help to establish the diagnosis of yellow nail syndrome, especially if the assocation of clinical anomalies is incomplete.

Adult↗
PubMed1978

Dinitrochlorobenzene therapy for alopecia areata.

Ninety patients with alopecia areata were treated with weekly applications to one side of the head of dinitrochlorobenzene (DNCB) dissolved in acetone, the other side of the head serving as control region. In 80 patients (89%) hair regrew either exclusively on the treated side, or considerably faster and denser on this side. The difference was noted, in the majority of cases, within eight weeks. The initial response, however, could not be maintained in all of these patients. Persistent response was observed in 72 patients (80%). Peribulbar round cell infiltrates were found to be more constant and denser on the treated side, suggesting that topically applied DNCB affects the peribulbar infiltrate present in alopecia areata. Possibly, the therapeutic result is due to altered local immunoregulation.

Adolescent↗
PubMed1978

[Genetic interpretation of linear skin abnormalities].

For the linear distribution of congenital skin lesions, modern genetics offers several explanations. Localized linear nevi may be due to somatic mutations. Generalized linear nevi may be the result of early somatic mutations or of gametic half chromatid mutations. The generalized linear patterns of incontinentia pigmenti, focal dermal hypoplasia and sex-linked chondrodysplasia punctata may be explained by functional X-chromosome mosaicism. The same mechanism may account for a peculiar striation of bones observed in focal dermal hypoplasia. Exceptional cases of incontinentia pigmenti and focal dermal hypoplasia in males may be due in part to the gonosome constitution XXY, and in part to gametic half chromatid mutations.

Bone and Bones↗
PubMed1977

Paraproteinaemia in erythema elevatum diutinum.

Paraproteinaemia (IgGkappa) was observed in a 68 year-old patient with erythema elevatum diutinum. The association of this skin disease with paraproteinaemia as already reported by other authors may indicate a pathogenetic relationship.

Aged↗
PubMed1977

[Alopecia areata: successful half-side treatment with DNCB].

In 46 patients with alopecia areata, one side of the head was treated with weekly applications of DNCB, dissolved in acetone. The therapeutic aim was mild contact dermatitis. The other side of the head served as control region. A therapeutic effect was noted in 36 patients: 22 patients showed regrowth of hair exclusively on the treated side, and in 14 patients regrowth of hair was considerably faster and more dense on the treated side. In 8 patients no regrowth was observed, and in 2 patients regrowth occurred on both sides without any difference of intensity. The difference between both sides with regard to hair growth was seen in all of the 7 patients with moderate involvement and in 12 out of 13 patients with extensive involvement; but also in 17 out of 26 patients with alopecia areata totalis or fere totalis. The difference was noted, in the majority of cases, within 3 months. These results prove the efficacy of DNCB treatment of alopecia areata.

Adolescent↗
PubMed1977

Induction of hair growth in alopecia areata with D.N.C.B.

43 patients with alopecia areata were treated with weekly applications of dinitrochlorobenzene (D.N.C.B.), dissolved in acetone, on one side of the head, with the other side serving as control region. The therapeutic aim was a mild contact dermatitis. A significant difference of hair growth between the treated and untreated sides was observed in 33 patients. 21 patients showed regrowth of hair exclusively on the treated side, and in 12 patients regrowth was considerably faster and more dense on the treated side. In the majority of patients the difference was noted within 3 months.

Administration, Topical↗
PubMed1977

Membrane associated antigens of human malignant melanoma. III. Specificity of human sera reacting with cultured melanoma cells.

Sera from melanoma patients, healthy donors, pregnant women and patients with types of tumors other than melanoma were tested on various melanoma lines as well as on a cultured brain tumor and adult skin fibroblasts, using a microimmune adherence test. Positive reactions against all cell lines were found in serum from each group of donors. The degree of reactivity was dependent on the cell line used. Sequential absorption with AB Rh+ and pooled platelets of more than 200 donors either reduced the titer of sera or rendered a great part of the sera negative, demonstrating that antibodies against HL-A antigens and other tissue antigens were involved. The remaining positive sera were further absorbed with pooled cells from 6- to 8-week-old fetuses. This step abolished the reactivity of most sera, indicating the relatively high frequency of antibodies in males and females against fetal antigens expressed also on melanoma and other cells. In order to determine the specificity of the few remaining positive sera, absorptions with three different melanoma cell lines, a brain tumor and fibroblasts were carried out. The results showed only partial cross-reactivity between different cell lines. No evidence was obtained from this study for the existence of a common cross-reacting membrane-associated antigen on human malignant melanoma. Antigens that could be readily detected seemed mostly to be tumor-associated fetal antigens.

Antibodies, Neoplasm↗
PubMed1977

Surgical treatment of erythroplasia of Queyrat.

An operative technique is described for the treatment of large lesions of erythroplasia of the penis. The defect on the glans and on the coronary sulcus is covered by a flap prepared from the external part of the prepuce. This therapy has been effective and has given a good functional result.

Aged↗
PubMed1977

Striation of bones in focal dermal hypoplasia: manifestation of functional mosaicism?

Striation of the metaphyseal regions of the long bones, a characteristic feature of the focal dermal hypoplasia syndrome, may be explained by functional X chromosome mosaicism. The following arguments are in favour of this hypothesis: (I) The striation of bones coincides with the zones of osteogenesis. (2) The skin lesions are distributed in a linear pattern as well. (3) The syndrome is probably inherited as an X-linked dominant trait. Thus, the linear pattern of both skin and bone lesions could be due to random X inactivation.

Bone Diseases, Developmental↗
PubMed1977

Sex-linked chondrodysplasia punctata?

Widespread atrophic lesions and pigmentary disturbances of the skin distributed in a linear or whorled pattern, are seen in some patients with chondrodysplasia punctata of the Conradi-Hünermann type. Arguments are presented in favor of the hypothesis that this association of anomalies constitutes a distinct genetic disorder, which is inherited as an X-linked dominant trait lethal in hemizygous males.

Adolescent↗
PubMed1977

Systemic retinoid therapy of systematized verrucous epidermal nevus (with 1 colour plate).

In a patient with systematized verrucous epidermal nevus, marked improvement was obtained with oral administration of a new aromatic retinoid (Ro 10-9359). Mild cheilitis and thinning of scalp hair were the only side effects obser Withved. continuous treatment the good result was maintained for 10 months. Further investigation is needed to determine, whether long-term oral administration of this new drug is feasible.

Administration, Oral↗
PubMed1977

[Necroses following the use of Pyoktanin].

In a patient suffering from chronic balanitis, necrotic lesions of the glans penis and the internal part of the prepuce occurred when treated with 1% gentian violet. Necrosis after treatment with gentian violet is a rarely seen complication which should be borne in mind.

Adult↗
PubMed1976

[Focal dermal hypoplasia with apocrine nevi and striation of bones (author's transl)].

In a 22 year-old female patient affected with focal dermal hypoplasia, multiple apocrine nevi occurred in the sternal region; these nevi may be part of the syndrome. Roentgenograms of the long bones revealed marked longitudinal striations. This anomaly represents a characteristic and hitherto underestimated feature of the syndrome.

Abnormalities, Multiple↗