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Biomedical subjects

R Grossman

Publications and source records attributed to R Grossman.

At least 109 records · Page 6Linked to original sources
PubMed1984

Nodular mediastinal amyloidosis.

A 67-year-old woman presented with supraclavicular lymphadenopathy, a large mediastinal mass, marrow plasmacytosis, and paraproteins, including free lambda light chains, in the serum and urine. Biopsies of the lesions demonstrated nodular amyloidosis, which was confirmed by ultrastructural and cytochemical analyses. Immunoperoxidase staining indicated that the amyloid was composed of lambda light chains. Nodular mediastinal amyloidosis is a rare manifestation of amyloidosis and appears to be a form of immunocytic amyloidosis.

Aged↗
PubMed1984

Left ventricular stroke volume determinations from radionuclide ventriculograms: the effects of photon attenuation.

To improve the accuracy of scintigraphic ventricular volume determination, which is limited by photon attenuation between the heart and the gamma camera, a method was developed for directly measuring the photon attenuation of radioactivity delivered as a bolus through a Swan-Ganz catheter into the right atrium. Comparison of the count rate recovered from this bolus with the total ex vivo measured activity determined by imaging an aliquot of the administered activity allowed calculation of the attenuation factor. Left ventricular stroke volumes determined scintigraphically by the count method in gated blood pool studies and then corrected with this attenuation factor correlated well with stroke volumes determined from thermodilution cardiac output and heart rate (r = 0.92; SEE, 6.1 ml). The agreement between the two measurements was markedly less when an average attenuation factor was employed for correction of scintigraphic volumes (r = 0.52; SEE, 14.8 ml). The results indicate that correction for photon attenuation is needed for accurate measurement of left ventricular volumes. Correction of left ventricular counts based on body weight or body surface area improves the accuracy of volume estimates.

Adult↗
PubMed1984

A survey of patient sources of prescription drug information.

A national telephone survey of 1,104 adults who had recently obtained a new prescription was undertaken to determine the nature and amount of drug information obtained. Sixty percent stated that physicians provided directions for use information with the pharmacy reported as about half as active. Only 3 to 6 per cent said they asked the physician or pharmacist for information. However, one in six respondents said they looked up the prescription in a drug reference book such as the Physicians Desk Reference.

Adolescent↗
PubMed1984

CT metrizamide myelography in multiple bilateral intrathoracic meningoceles.

An intrathoracic meningocele is a protrusion of spinal meninges through an intervertebral foramen into the thoracic cavity. The majority occur in association with neurofibromatosis, and bilateral or multiple lesions are rarely seen. In conventional radiography, small meningoceles may be hidden behind other mediastinal structures. To investigate paraspinal masses, computed tomography (CT) with intrathecal contrast material is likely to result in more frequent detection of unsuspected lateral meningoceles. This report details our experience with CT metrizamide myelography in a case of multiple bilateral intrathoracic meningoceles.

Aged↗
PubMed1980

The gastric cardia in double-contrast study: its dynamic image.

Difficulties in evaluating the gastric cardia are well known and may often be resolved with the double-contrast technique. Special views to show the cardia en face were obtained in 200 double-contrast examinations. Four basic patterns were recognized. Similar appearances could be reproduced by protruding or retracting the lower end of the esophagus during the radiography of intact stomachs obtained at autopsy. Influenced by muscle relaxants, swallowing, or deep breathing, cardia patterns were found to be interchangeable in the same patient and same examination. The disappearance of the protrusion pattern at the cardia in the course of swallowing is an important means of distinguishing normality from a tumor in this area. Any significant deviation from the normal geometry of the cardia as displayed by double contrast indicates an abnormality. Examples of abnormalities are illustrated.

Carcinoma↗
PubMed1979

Simple butyrate esterase stain for monocytes.

The esterases used to identify monocytes are best demonstrated using alpha-naphthyl butyrate as substrate. However, the reagents commonly used for this stain are time-consuming to prepare and are unstable. This report describes a quick, easy, and reproducible staining method using stable reagents which are readily available commercially but which may also be prepared in the laboratory.

Butyrates↗
PubMed1978

An unusual variant of membranous nephropathy with abundant crescent formation and recurrence in the transplanted kidney.

A patient with what initially appeared to be a typical membranous nephropathy had a progressive course to renal failure, nephrectomy, and transplantation. The nephrectomy specimen revealed abundant glomerular crescents and capsular synechiae. Post-transplantation the patient again developed a membranous nephropathy with florid crescents. Radioimmunoassay and indirect immunofluorescence tests failed to reveal anti-glomerular basement membrane antibody in the serum or kidney. It appears that there is a form of membranous nephropathy with crescent formation, unrelated to anti-GBM antibody, which has the capacity to recur after transplantation.

Adult↗
PubMed1976

The catecholamine pontine cellular groups locus coeruleus, A4, subcoeruleus in the primate Cebus apella.

The distrubution of CA neurons of areas A6 and A4 was delineated in Cebus apella monkey using the fluorescent histochemical technique of Falck and Hillarp. Cytospectroscopy was utilized for CA differentiation. The noradrenergic cellular regions A6, A4, and subcoeruleus have extensively increased in size in the Cebus as compared to the rat and appear to be separate nuclear regions. Area A4 is made up of two cellular subgroups: a more abundant lateral magnocellular area with cells as large as 45 mum and a smaller medial parvocellular group where the neurons are spindle-shaped and lie within 10-100 mum of the ependyma. The neuronal processes of A4 tend to be directed towards the flocculus and paraflocculus of the cerebellum. Some processes seem to enter the ependyma and others end subependymally. The functional significance of the pontine CA neurons is discussed.

Animals↗