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Biomedical subjects

R Gonzalez

Publications and source records attributed to R Gonzalez.

At least 379 records · Page 21Linked to original sources
PubMed1980

Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells.

Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to isolated extracellular matrix. When analyzed by polyacrylamide gel electrophoresis in sodium dodecylsulfate solutions, the extracellular matrix was shown to be primarily composed of a protein of identical migration and molecular weight to fibronectin. Tumor-cell adhesion to fibronectin-coated polyvinyl surfaces mimicked the rapid rate of attachment of tumor cells to extracellular matrix, and tumor cells adherent to either extracellular matrix or fibronectin-coated polyvinyl dishes adopted an unusual, highly spread and flattened morphology with numerous small projections. These results suggest that fibronectin associated with the endothelial basement membrane may be, in part, responsible for establishing an adhesive gradient that could be important in malignant cell extravasation.

Animals↗
PubMed1980

Ultrasonic evaluation of hepatic and splenic trauma.

Blunt abdominal trauma comprises a major portion of surgical emergencies. These patients require imaging modalities that are rapid and accurate. In two patients with upper abdominal trauma, gray scale ultrasound was successfully used both for initial diagnosis and for monitoring the postoperative course.

Accidents, Traffic↗
PubMed1980

Obstructive uropathy, renal failure, and sepsis in the neonate--a surgical emergency.

Two infants who had obstructive uropathy accompanied by renal failure and sepsis are reported herein. Diagnostic and therapeutic techniques used to treat this type of surgical emergency are discussed in the order they were performed, as follows: (1) resuscitation for severe fluid and electrolyte disturbances; (2) gathering of cultures and initiation of antibiotic therapy; (3) the decision of whether or not dialysis is required, as well as when and how diagnostic evaluation should proceed; (4) the decision of whether dialysis is necessary or whether correction of obstructive uropathy can begin; and (5) the choice of the best operative procedure for this individual. This article emphasizes the necessity for a multidisciplinary team approach to these patients.

Acute Kidney Injury↗
PubMed1980

Butriptyline: improved gas-liquid chromatographic method using a nitrogen-phosphorus detector for its determination in serum.

We report a sensitive and specific method for the determination of butriptyline concentrations in serum by gas-liquid chromatography with a nitrogen phosphorus detector. The detection limit is 2 ng/ml, based on 3 ml of serum or plasma. The method has been validated in human volunteers receiving a single oral dose of 75 mg butriptyline hydrochloride.

Chromatography, Gas↗
PubMed1980

Enhanced atrioventricular nodal conduction in a patient with dual extranodal pathways.

A patient was admitted to the hospital with wide complex tachycardia and a history of recurrent palpitations. Electrophysiologic studies showed evidence of dual atrioventricular (AV) accessory pathways. One proved to be an anteroseptal (possible right anterior) pathway probably capable of only unidirectional conduction. The other pathway was in the posterior septum and conducted only in the retrograde direction. The tachycardia circuit involved anterograde conduction via either the AV node-His axis or the anteroseptal pathway and retroconduction over the posteroseptal accessory pathway. In addition, enhanced AV nodal conduction coupled with two accessory AV nodal pathways has rarely been described in English medical literature. Previous reports have carefully described anatomic, electrocardiographic, and electrophysiologic evidence of more than one accessory pathway in patients with the Wolff-Parkinson-White syndrome. The introduction of surgical techniques for ablation of an accessory pathway demands precision in the electrophysiologic evaluation of patients with ventricular preexcitation. Reported herein is a patient with the unique finding of two extranodal accessory pathways and enhanced atrioventricular (AV) nodal conduction (or AV nodal bypass).

Atrioventricular Node↗
PubMed1980

Diverticula of the male urethra.

Recently, we have seen 8 patients, ranging in age from 4 to 72 years, who each had a diverticulum of the anterior urethra. Our experience with these patients, combined with a thorough review of the literature, has demonstrated that while the cause and classification of these lesions often are controversial, multifaceted and confusing, the best treatment may be determined simply through accurate description of the size, thickness and anatomic location. Many diverticula, regardless of their cause, are contained within an intact corpus spongiosum and can be treated successfully transurethrally. Those diverticula that may leave a cavity too large to drain well, are too thick to cut transurethrally or lack adequate surrounding supportive tissue are treated bet by open surgical excision and urethral closure.

Adult↗
PubMed1980

Renal cancer invading the inferior vena cava: clinical review and anatomical approach.

Renal cell carcinoma invades the inferior vena cava in approximately 5 per cent of the patients. The only effective therapy for intravascular renal cell carcinoma is radical nephrectomy and complete removal of the tumor thrombus. To formulate a reasonable operative approach to intracaval renal cell carcinoma we have reviewed our experience with 6 cases as well as the experience of other investigators. In addition, we studied the collateral circulation of the renal veins as described by various anatomists, and to this information we have added our experience with inferior venacavography and with intraoperative and autopsy dissections. Herein we describe a new preoperative staging system for intravascular renal cell carcinoma. The operative approach to each stage is discussed in detail beneficial intraoperative maneuvers are described and illustrated.

Adenocarcinoma↗
PubMed1980

Ultrasound detection of uterine abnormalities after diethylstilbestrol (DES) exposure.

Diethylstilbestrol (DES) was widely prescribed to pregnant women from 1940 to 1960. This resulted in multiple benign abnormalities of the genital tract and occasional malignant transformation in women who had been exposed to DES in utero. Over 300 cases of clear cell adenocarcinoma of the vagina have been described to date. In this study, 18 DES-exposed women and 20 normal age-matched controls were studied with ultrasound. An estimated uterine volume of 49.4 cm3 +/- 25.5 SD was found in the exposed subjects, compared with 90 cm3 +/- 22 SD in the normal subjects. Three out of 18 women (16%) had a T-shaped uterus. Ultrasound can detect some of the uterine abnormalities which occur due to DES exposure.

Adult↗
PubMed1980

Vulvo-vaginal candidosis and its treatment with the new fungicidal substance econazole.

Thirty-five patients suffering from vulvo-vaginal candidosis were treated with econazole vaginal suppositories for 3 consecutive days, on a once-a-day schedule. In 80% of the cases clinical symptoms subsided and the mycological findings became negative. No side-effects were observed or reported, and the tolerability was excellent.

Candidiasis, Vulvovaginal↗
PubMed1979

The artificial bladder sphincter AS-721 for the treatment of incontinence in patients with neurogenic bladder.

An artificial sphincter was placed at the bladder neck in 9 male and 3 female patients with urinary incontinence and neurovesical dysfunction. Criteria for selection of patients included complete bladder emptying, absence of vesicoureteral reflux and normal upper urinary tracts. Of the 9 male patients 6 became continent, with an average followup of 25 months, and only 1 mechanical failure occurred. The results were less satisfactory in the 3 female patients, 2 of whom eventually required supravesical diversion. Artificial sphincters are valuable in the treatment of certain children and adults who are incontinent because the pelvic floor is damaged or denervated, even if they have neurovesical dysfunction.

Adolescent↗
PubMed1979

Rapid serogroup identification of Neisseria meningitidis by using antiserum agar: Prevalence of serotypes in a disease-free military population.

Nasopharyngeal cultures from 414 Marines were plated directly onto antiserum agar containing the antibiotics vancomycin, colistin, and nystatin for meningococcal isolation and serogroup identification. Meningococci were isolated from 267 Marines, giving a carrier prevalence of 64.5%. A total of 58% of the isolates could be placed into serogroups; of these 22.3% were group B, 4.7% were group C, 25.7% were group Y, 24.3% were group W135, and 23.0% were group 29E. No serogroup A organisms were recovered. Serotyping by agar gel double diffusion was performed on 148 strains. More than 70% of these strains were nontypable, and the disease-associated serotype 2 was present only in two group Y isolates. The same 148 isolates were also classified by major outer membrane protein patterns after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Polyacrylamide gel electrophoresis pattern IV was most common among all serogroups. The data demonstrate the effective use of antiserum agar for meningococcal surveillance and document the frequency of specific serotypes and polyacrylamide gel electrophoresis types among carrier isolates obtained from a nonrecruit military population.

Carrier State↗
PubMed1979

Deviation of the prostatic urethra in pelvic masses.

A cystourethrogram in the anteroposterior view can be useful for the diagnosis of a mass in the true pelvis in males, particularly when rectal examination is not possible. The technique is simple and rapid and has the same morbidity as simple urethral catheterization. This maneuver should be used whenever a pelvic mass is suspected in a male and physical findings fail to confirm its presence.

Adenocarcinoma↗
PubMed1978

Intermittent hydroephrosis. A cause of abdominal pain.

Intermittent hydronephrosis may appear as acute abdominal pain. Between episodes of pain, the patient may be asymptomatic, and the intravenous urogram usually will be normal. The condition is diagnosed from intravenous urograms taken either during an episode of pain or after hydronephrosis has been precipitated by hydration. There are many causes of intermittent hydronephrosis; however, the closed renal pelvis and nondistensible ureteropelvic junction are important factors in nearly all cases. Pyeloplasty is the best treatment and is usually curative.

Abdomen↗