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Biomedical subjects

R Glaser

Publications and source records attributed to R Glaser.

At least 253 records · Page 14Linked to original sources
PubMed1972

Hybridization of Burkitt lymphoblastoid cells.

Burkitt lymphoblastoid cell lines have been fused to mouse and human cell lines with the use of inactivated Sendai virus. The heterokaryons have developed into somatic cell hybrids of both parental cell types. Chromosome analyses confirm that cells now growing in selective medium are hybrids. Initial observations of preparations of the hybrid cells reveal that 5'-iododeoxyuridine can induce continued synthesis of Epstein-Barr virus antigens by these hybrid cells.

Animals↗
PubMed1972

Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells.

A Burkitt lymphoblastoid cell line, P3J-HR-1, was fused and hybridized to a human sternal marrow cell line. The somatic cell hybrids were negative when examined for Epstein-Barr virus (EBV) markers. When the hybrid cells were exposed to 5-iododeoxyuridine, both EBV-specific antigens and virus particles were induced as determined by the immunofluorescence test and by electron microscopy. The data presented suggest that the EBV genome can be transferred from a lymphoblastoid cell to another cell type during cell hybridization, that the EBV genome can persist in the hybrid cells for long periods of time, and that synthesis of the virus can be induced in the heterokaryons.

Antigens, Viral↗
PubMed1972

Absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2.

Hamster cells which transformed after exposure to herpes simplex virus type 2 previously irradiated with ultraviolet light were tested for the presence of hamster leukosis viruses or their virus-specific antigens. Three techniques that were used did not detect the presence of either hamster C-type particles or antigens commonly associated with such structures. The implication of these findings to current concepts of virus oncology is discussed.

Animals↗