Biomedical subjects
Publications and source records attributed to R Giurgea.
Administration of a unique dose of thiourea (7 mg per kg b.w.) in the 7th day of life to broiler chickens affects in different manners the jejunal absorption of glucose and that of leucine. Methionine supplementation of the fodder (1.5 g per kg) during 40 days affects--in an age-dependent manner--the glucose absorption, but not that of leucine.
Leucotrofina administration in Wistar rats induced in thymus an increase of total protein content and of protein synthesis from 14C-leucine, simultaneously with a raise in the AlAT activity. Adrenal glands were not affected. Leucotrofina administration on the background of Cyclophosphamide induced modifications restored at normal values some of the thymic parameters (total protein content and RNA content) but the ascorbic acid content in the adrenals remained lowered.
A 90-day Timorom treatment of rats of both sexes modified some of the carbohydrate metabolism parameters. Some of the modifications were different in male and female rats. Glycogen storage was increased, while liver GPa activity was decreased in the male rats, but those modifications ran in the opposite direction in the female rats. In our opinion, these different reactions of male and female rats to Timorom (containing a nonselective beta-adrenergic blocking agent--timolol) depended on the different ways by which the glycogen phosphorylase system is activated. Many of the biochemical modifications, obtained after the Timorom treatment, disappeared at the end of the first post-treatment month.
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In order to examine the regulatory function in glucidic metabolism of the pigeon pineal gland the authors used the model of complete pancreatectomy associated or not with pinealectomy and treatment with Epifizan. It results that the pineal gland has a hypoglycemic action and partially compensates the lack of the endocrine pancreas.
Adult Wistar rats of both sexes were treated with Cyclophosphamide (a Romanian product), for 12 month. The Cyclophosphamide was given in the food, in 3 different doses (0.31, 1.25, respectively 2.5 mg/kg body weight). The modifications produced in the thymus and blood plasma were dose and sex dependent, and they emphasize an alteration in the protein metabolism, which is not accompanied by an involuntion of the thymus itself.
Leucotrofina administration to chickens of two different ages (2,5 IU/chicken to 3 days old chickens, and 5 IU/individual to 21 days old chickens), associated with an antigen (1 / 1000 Bovine Serum Albumin) (0,25 ml, respectively 0.5 ml/animal in young and in older chickens) affected several blood serum parameters as: the antibodies concentration, the gamma-globulins, the total proteins, and the nitrogen of the free amino-acids content in a manner corresponding to the experimental model and to age the of the animals.
The administration of hydrocortisone-acetate to adult Wistar rats induced emphasized biochemical modifications in the thymus, together with the weight decrease of the gland. Liver was less affected and adrenal's function was suppressed, as shown by the increase of the ascorbic acid content. The treatment did not induce a stress situation.
A 10 days Leucotrofina or Timolimfotropina administration induced in Wistar rats a rise of glycemia and liver glycogen content, and a decrease of glycogen-phosphorylase a activity. These modifications lasted in time and may be due to an activation of the hepatic gluconcogenetic pathway, via a stimulated glucocorticoid production.
Adult male rats were treated for 10 days with a thymic extract (Leucotrofina-L, or Timolimfotropina-T, Ellem Milano, Italy), in a daily dose of 0.1 ml/100g body weight. 5 days after the end of the treatment, rats were sacrificed and liver was removed. The modifications in the liver were of the same direction for noth thymic extracts (an increase of the total protein content and of DNA concentration and a decrease of RNA concentration).
Thymocytes (isolated from the thymus of Wistar rats) were put in contact with the glucocorticoid hormones (hydrocortisone acetat, prednison, respectively superprednol) in the Warburg cup. The in vitro effects upon the biochemical parameters: total proteins, gammaglobulines, RNA, DNA, glucose and free nitrogen aminoacids, are more emphasized for both synthetic hormones than hydrocortisone, establishing a decreases in their levels.