Postpartum aggression in mice: the influence of suckling stimulation.
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Biomedical subjects
Publications and source records attributed to R Gandelman.
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Testosterone propionate (TP) administered from Day 21 through Day 50 of life enhanced the aggressiveness of castrated and neonatally TP-treated juvenile male and female mice and, to a lesser extent, enhanced the aggressiveness of nonneonatally androgenized females. In addition, the enhanced aggressive behavior of juvenile male and female mice was directed principally toward juvenile male but not female opponents and was inhibited by the application of urine from juvenile females to the fur of juvenile male opponents. These experiments indicate that androgen and olfactory stimuli modulate the aggressive behavior of juvenile mice in a manner similar to that of adult animals.
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The daily administration of estradiol benzoate (EB) to lactating mice that previously exhibited aggression toward a male intruder reduced the amount of time subsequently spent fighting as well as the total number of animals that fought. EB treatment also depressed body weight of the dams and their lactation performance. Daily progesterone treatment only reduced lactation performance.
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A significant correlation was shown in Rockland-Swiss albino mice between the number of fetuses and maternal nest-building performance as assessed by the amount of nesting material gathered into the cage. The greater the number of fetuses, the more nesting material was gathered. A significant correlation first appeared on Day 4 and was maintained until Day 18 of gestation.
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