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Biomedical subjects

R G Fischer

Publications and source records attributed to R G Fischer.

At least 19 recordsLinked to original sources
PubMed1992

Prevalence and distribution of cervical dentine hypersensitivity in a population in Rio de Janeiro, Brazil.

The prevalence, distribution and possible causal factors of cervical dentine hypersensitivity were studied in a population from a Marine Dental Clinic in the city of Rio de Janeiro, Brazil. A total of 635 patients were examined for the presence of cervical dentine hypersensitivity by means of a questionnaire and intraoral tests (air and probe stimuli). There were 157 patients (25%) reporting to have hypersensitive teeth, but only 108 patients (17%) were diagnosed as having cervical dentine hypersensitivity. The prevalence of hypersensitivity was higher among females than males, but this difference was not statistically significant. Most females with hypersensitivity were aged 20-49 and most males were aged 40-59. Incisors and premolars had the highest prevalence of dentine hypersensitivity to air and probe stimuli, while molars had the lowest. The presence and history of dentine hypersensitivity were positively correlated with previous exposure to periodontal treatment. Only a few of the patients who claimed to have dentine hypersensitivity had tried treatment with desensitizing toothpastes or sought professional help.

Adolescent↗
PubMed1991

Clinical evaluation of pulp and dentine sensitivity after supragingival and subgingival scaling.

The exposure of dentinal tubules by the removal of root cementum on scaling procedures has been proposed to be a source of pulp injury and to cause dentine hypersensitivity. The aim of this study was to evaluate the sensitivity of the pulp and dentine after supragingival and subgingival scaling. Eleven patients with periodontally diseased mandibular incisors were selected. The subjects were divided into two groups according to marginal bone loss. The pulp sensitivity was evaluated by an electric pulp test. Dentine sensitivity was evaluated with two forms of controlled stimulations (probe and air-jet) and with a questionnaire. No changes in pulp sensitivity were found after scaling, but a clinically significant increase in dentine sensitivity to probe and/or air stimuli was observed in 6 patients. Five of these were also sensitive to daily life stimuli. A natural mechanism of desensitization seemed to have occurred two weeks after subgingival debridement. This study showed that supragingival and subgingival scaling might cause a more or less transient occurrence of dentine hypersensitivity.

Adult↗
PubMed1985

Severe contact dermatitis due to nitroglycerin patches.

As shown by the two cases described, contact dermatitis due to nitroglycerin patches can be severe. Patients should be counseled to rotate application sites daily and report to the physician any signs of skin irritation.

Administration, Topical↗
PubMedDate not supplied

Disposable insulin syringe reuse and aseptic practices in diabetic patients.

Diabetic patients are traditionally taught to discard plastic syringe/needle units after a single use and to employ aseptic technique for administering insulin injections. We surveyed 87 diabetic outpatients for compliance with aseptic recommendations. We then studied prospectively the effects of reusing disposable syringes in 56 diabetic patients who reused syringes a mean of 6.6 times for 8.3 months and an aggregate of 23,664 injections. Almost half (49%) of diabetic patients in a combined university clinic and private practice reused supposedly disposable insulin syringes a mean of 3.9 times. Compliance with standard aseptic precautions was poor, with only 29% of patients following recommended practices. No adverse effect of syringe reuse was identified. The authors conclude that diabetic patients frequently reuse disposable syringes, without apparent harmful effect.

Asepsis↗
PubMedDate not supplied

"Platinum-pyrimidine blues" and related complexes: a new class of potent antitumor agents.

The diaquo species of cis-dichlorodiammineplatinum (II) reacts with pyrimidines and substituted pyrimidines to form very soluble, deep blue complexes. These are believed to consist of mainly monomeric species containing one pyrimidine moiety liganded to each platinum. The structures of the complexes are largely uncertain at this time. We describe the methods of synthesis and characterization of approximately 70 such complexes, with a suggested classification scheme, incluse complexes show superior activity against the ascites Sarcoma 180 tumor in Swiss mice when compared to cis-dichlorodiammineplatinum (II). Initial screening test results and dose schedule-dependency results indicate we can achieve 100% cures in this tumor-host system. Activity is also shown against the Rauscher leukemia, Ehrlich ascites, and ADJ/PC6A tumors. Microscopic histopathologic studies of resulting kidney lesions show that the "platinum-uracil blue" complex causes only minor focal damage to the proximal convoluted tubules at a therapeutic dose level, rather than the generalized degenerative changes so prominent and dose limiting noted with cis-dichlorodiammineplatinum (II).

Animals↗