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Biomedical subjects

R Friedman

Publications and source records attributed to R Friedman.

At least 199 records · Page 11Linked to original sources
PubMed1981

Psychobiology of experimental hypertension: evaluation of the Dahl rat lines.

The Dahl salt-sensitive (DS) and salt-resistant (DR) rat lines were selectively bred to show opposite genetically determined blood pressure responses to excess sodium chloride ingestion. These animals have provided significant anatomical, physiological, and biochemical data concerning the pathological mechanisms of experimental hypertension. Research is also being conducted to determine the relevance of psychobiological and behavioral variables in these two lines. The rationale for the selection and maintenance of the Dahl model and the physiological, biochemical, and behavioral characteristics which distinguish DS and DR rats are presented. Although originally developed for the study of salt-induced hypertension, special attention is given to the application of this animal model in behavior genetic research, stressing its inherent advantages and limitations. The use of the Dahl model in psychobiological studies and the utility of the model for future behavioral, genetic, and psychophysiological research are also detailed.

Animals↗
PubMed1981

Gallium scintigraphy demonstration of an appendiceal mucocele: a proposed mechanism of uptake.

An appendiceal mucocele demonstrated intense early avidity for Ga-67, despite the lack of inflammatory cells to account for the uptake. It is proposed that the acid mucopolysaccharide component of the mucus within the lumen and lining cells accounted for the uptake of the gallium ion, in a similar manner to the uptake of its analogue, the ferric ion, as demonstrated by intense staining of mucus by the colloidal iron technique.

Aged↗
PubMed1981

Long-term effect of phenobarbital on cognitive function in children with febrile convulsions.

Psychometric tests were performed on 50 children with a history of febrile convulsions. Twenty-five of these had received daily phenobarbital for a mean of 35 months; 25 had received no phenobarbital. The two groups were matched for sex, age at the time of testing, race, and socioeconomic status. The tests used were the Wechsler Preschool and Primary Scale of Intelligence (WPPSI), the Matching Familiar Figures Test, and the Children's Embedded Figures Test. There were no significant differences in test results between the two groups.

Child↗
PubMed1980

Genetic influence on brain catecholamines: high brain noradrenaline in salt-sensitive rats.

1. Rats genetically sensitive to salt-induced hypertension showed higher levels of plasma noradrenaline and adrenaline than rats genetically resistant to hypertension. 2. The hypertension-sensitive rats had higher hypothalamic noradrenaline and lower adrenaline than resistant rats. 3. In response to a high salt diet brain-stem noradrenaline increased in sensitive rats and resistant rats exhibited a decrease on the same diet.

Animals↗
PubMed1979

Meningococcal sepsis with endophthalmitis.

Endophthalmitis is a rare complication of meningococcemia. A child had endophthalmitis as the initially occurring complaint. Although both eyes appeared inflamed, the pupil in the right eye was fixed and dilated, the fundus could not be seen, and a hypopyon was seen in the right anterior chamber. There was gradual improvement when the child received antibiotic therapy. Since the introduction of antimicrobial drugs, endophthalmitis has rarely been observed as a complication of meningococcal disease. However, this report is evidence that meningococcemia may occur with unusual sites of local infection.

Child, Preschool↗
PubMed1979

Differential development of salt-induced and renal hypertension in Dahl hypertension-sensitive rats after neonatal sympathectomy.

Rats with a genetic susceptibility to salt hypertension were given repeated neonatal injections of guanethidine. Vascular reactivity and tissue catecholamine concentrations indicated that a peripheral sympathectomy had been produced. Chemically sympathectomized rats had lower blood pressure than controls while fed a diet containing 0.4% NaCl. Furthermore, the dramatic rise in blood pressure exhibited by control rats fed a diet containing 8.0% NaCl was completely absent in sympathectomized rats similarly fed. The absence of salt-induced hypertension was observed regardless of whether the animals were anesthetized with ether or pentobarbital or had the blood pressures determined in an unanesthetized state. Finally, two-kidney Goldblatt hypertension did develop in sympathectomized rats, but to a level below intact rats similarly treated.

Angiotensin II↗