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Biomedical subjects

R Frahm

Publications and source records attributed to R Frahm.

59 records · Page 4Linked to original sources
PubMed1979

Extraamniotic intermittent administration of prostaglandin F2 alpha during the first and second trimesters of pregnancy.

Extraamniotic application of prostaglandin F2 alpha (PGF2 alpha) was used for legal abortion in the series of 1012 women. The pregnancies were terminated by abortion between the 6th and 27th weeks of pregnancy. In 86.7% of the cases, intermittent extraamniotic application of PGF2 alpha led to complete or incomplete abortions. Of the 26 failures, nine were caused by technical difficulties. In 17 primigravidae, the cervical canal remained closed. There were no statistically related differences between the different weeks of the pregnancy with regard to success and failure rates. The mean PGF2 alpha dose and abortion time increased significantly (p less than 0.01) with increasing duration of pregnancy. 80% of the patients suffered from undesirable side effects. The morbidity rate for the period up to six weeks following the abortion was 3.2%.

Abortion, Incomplete↗
PubMed1977

[Therapeutic induction of abortion in the 1st and 2nd trimesters with intramuscular 15-methyl-prostaglandin F2 alpha].

The effectiveness of intramuscular 15-methyl-prostaglandin F2alpha (15-methyl-PGF2alpha) application for therapeutic abortion was studied in 16 women during the first and second trimester (12 to 17 weeks) of pregnancy. 250 microgram 15-methyl-PGF2alpha were administered initial and at intervals of 2 hours. Of the 16 subjects, 2 aborted completely, 13 aborted incompletely and 1 failed to abort. The mean abortion time for the 15 successful abortions was 11,25 hours and the mean 15-methyl-PGF2alpha dosage 1,35 mgs. Vomiting and diarrhea were the most prevalent side effects occurring in 12 of 16 patients. No serious complications occurred. In 9 women between 7 to 13 weeks of pregnancy a single intramuscular injection of 250 microgram 15-methyl-PGF2alpha was administered 11 to 13 hours prior to vacuum aspiration. All subjects had a gradual softening and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. All subjects had a gradual softning and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. Intramuscular administration of 15-methyl-PGF2alpha appears to be an effective abortifacient. Gastro-intestinal side effects can be reduced by antiemetic and antidiarrheal agents or lowering the initial dose of 15-methyl-PGF2alpha.

Abortion, Therapeutic↗
PubMed1976

[The problem of rifampicin therapy in pregnancy].

Report on a 24 years old first pregnant woman with chronic pyelonephritis, treated for 1 1/2 years, also during pregnancy, with high doses of rifampicin (1200 mgs/day). After normal delivery in the 42 th. week of pregnancy there were bleedings both in mother and newborn with demonstrable temporary disturbances in liver-function and coagulation system. Especially the coagulation factors produced in the liver were concerned. The complications after rifampicin carried out the conclusion that rifampicin should be given in pregnancy only with exact indication.

Blood Coagulation Disorders↗
PubMed1975

[Clomiphene--its use from stimulation test and for treatment of functional sterility].

There is reported on application of clomiphene (Clostilbegyt-EGYT Pharmaceutical Works, Budapest, Hungaria) in 17 patients for a clomiphene-stimulation-test and in 34 patients with functional sterility on 124 cycles. The dosage was between 50 to 150 mg p.d. for 5 to 7 days and was adapted individually. 12 patients responded to clomiphene-stimulation-test positively and in 4 ovarian hypoplasias and one Anorexia nervosa in acute phase, the clomiphene-stimulation-test was negatively. From the 34 patients with functional sterility 18 women were in 21 times gravid, 13 women could be delivered on term; in 8 cases it was an abortion. By reason of the findings after a clomiphene therapy a gravidity can be accepted, if the hyperthermic phase in the BBT existed for more than 25 days. For a repetition - treatment a dosage is recommended with 150 mg p.d. clomiphene for 7 days.

Adult↗