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R Ferrando

Publications and source records attributed to R Ferrando.

138 records · Page 8Linked to original sources
PubMedDate not supplied

Animal feed additive regulation in the Common Market: rules, principles and ideas.

The fundamental factors which govern legislation relating to the use of additives are examined. The rules advocated are as follows: 1) All additives unless licensed remain strictly prohibited. 2) There must be a severe but realistic appraisal of additives to be authorised, taking into account the interests of the farmer and the health of the consumer, particularly in respect of cumulative toxicity and relay toxicity. 3) Periodic revision of licenses is necessary in the light of experience acquired and of new scientific knowledge. 4) Strict regulation of veterinary dispensing is necessary and it should not be possible to use prohibited additives through the lack of such a regulation. In other respects the veterinarian should prescribe substances which might leave residues only when there is adequate time for their disappearance before slaughter or in animals where the products are not for human consumption. 5) It should be possible to monitor all regulations. 6) It should be impossible to use compounds or drugs similar to those already authorized without new investigations and experiments on such additives. 7) Guidelines must be produced. Such European guidelines are now being discussed by a committee of experts. We hope that such guidelines will be studied by the FDA and a Joint Committee will be organised with the European Commission for relevant discussions.

Animal Feed↗
PubMedDate not supplied

Principles of a full 'relay toxicity' experiment and results conducted with carbadox, a feed additive used as growth promoter for growing swine.

Relay toxicity is a new approach which permits an evaluation of the harmlessness of residues found in tissue, for the human consumer. Farm animals, swine for example, received high quantities of the additive over a long period. The swine were sacrificed without any withdrawal. Their meat and liver were added to the feed ration of laboratory animals to study the eventual problems of residue and metabolites. The following experiments were performed using carbadox:--Levels of carbadox up to 200 ppm were added to the swine ration (a maximum of 20 ppm is authorized). The meat and dehydrated liver were given in doses of 20% and 10% respectively, in the rat feed for 2 years or 3 generations.--The fresh meat, frozen then thawed at the time of use, was distributed to dogs daily for 7 1/2 years. No abnormalities were found, either in the growth of the animals or in their descendants. No abnormalities were observed macroscopically or microscopically after sacrifice. Relay toxicity gives high coefficients of security when the additive is used without withdrawal up to the time of sacrifice. This study demonstrated that the use of carbadox in swine doesn't present any disadvantage to the human consumer.

Animals↗