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Biomedical subjects

R E Page

Publications and source records attributed to R E Page.

At least 55 records · Page 3Linked to original sources
PubMed1994

Linkage analysis of sex determination in the honey bee (Apis mellifera).

A colony-level phenotype was used to map the major sex determination locus (designated X) in the honey bee (Apis mellifera). Individual queen bees (reproductive females) were mated to single drones (fertile males) by instrumental insemination. Haploid drone progeny of an F1 queen were each backcrossed to daughter queens from one of the parental lines. Ninety-eight of the resulting colonies containing back-cross progeny were evaluated for the trait 'low brood-viability' resulting from the production of diploid drones that were homozygous at X. DNA samples from the haploid drone fathers of these colonies were used individually in polymerase chain reactions (PCR) with 10-base primers. These reactions generated random amplified polymorphic DNA (RAPD) markers that were analyzed for cosegregation with the colony-level phenotype. One RAPD marker allele was shared by 22 of 25 drones that fathered low brood-viability colonies. The RAPD marker fragment was cloned and partially sequenced. Two primers were designed that define a sequence-tagged site (STS) for this locus. The primers amplified DNA marker fragments that cosegregated with the original RAPD marker. In order to more precisely estimate the linkage between X and the STS locus, another group of bees consisting of progeny from one of the low-brood viability colonies was used in segregation analysis. Four diploid drones and 181 of their diploid sisters (workers, nonfertile females) were tested for segregation of the RAPD and STS markers. The cosegregating RAPD and STS markers were codominant due to the occurrence of fragment-length alleles. The four diploid drones were homozygous for these markers but only three of the 181 workers were homozygotes (recombinants). Therefore the distance between X and the STS locus was estimated at 1.6 cM. An additional linked marker was found that was 6.6 cM from the STS locus.

Animals↗
PubMed1994

Duplication of the thumb. A 20-year retrospective review.

Thumb duplication is a common congenital abnormality accounting for 6.6% of all hand deformities. The object of the primary surgery is to achieve a thumb with aligned joint surfaces and epiphyses perpendicular to the long axis, central flexor and extensor tendons, and adequate collateral ligaments. Experienced surgeons with an understanding of the abnormal anatomy and knowledge of the numerous refinements in technique cannot guarantee a flawless result. Of 43 cases treated in this Unit during the period 1970-1989 49% were noted to have secondary deformities. Angulation at the IP and/or MP joints were the most commonly observed problems. Unsatisfactory results were seen with a greater frequency following correction of the more complex deformities.

England↗
PubMed1993

Cutaneous malignant peripheral nerve sheath tumour (MPNST) of the hand: a review of current literature.

Malignant peripheral nerve sheath tumours (MPNST) are spindle cell sarcomas normally situated in the deep soft tissues. Cutaneous MPNST is an uncommon variant, usually occurring in the head and neck. When it arises in the upper limb this tumour may pose a considerable diagnostic and therapeutic problem. We present a case of cutaneous MPNST arising in the hand. Tumour extension was exclusively perineural along three major nerve trunks from an interdigital origin. Current knowledge of the clinical behaviour of cutaneous MPNST is reviewed.

Amputation, Surgical↗
PubMed1989

Flexor tendon repair in zone 2 followed by controlled active mobilisation.

Over a two-year-period, 34 adult patients who had suffered zone two flexor tendon injuries to 38 fingers (70 tendons) were managed post-operatively by a regime of early active mobilisation. The results of this technique, assessed by the Strickland criteria after a mean follow-up period of 10.2 months, compared favourably with other more cumbersome methods.

Adolescent↗
PubMed1988

Carcinoma cuniculatum of the hand.

Carcinoma (epithelioma) cuniculatum is an uncommon variety of squamous cell carcinoma formerly considered to be limited to the foot. It has recently been reported in other parts of the body. We report a case in the hand and describe its management.

Carcinoma, Squamous Cell↗
PubMed1984

Immediate excision and skin graft of a friction burn in a replanted thumb with a note on its usefulness and indications.

A case is presented in which an area of friction burn was excised from the dorsum of a replanted thumb and the wound closed with a split-skin graft. In our experience successful revascularisation of similar injuries has often been followed by progressive venous failure. It is suggested that this technique, by decompressing the tissues, may prevent stagnation and propagation of thrombus, protect the interpositional graft and avoid subsequent venous failure with loss of the replanted digit.

Adult↗
PubMed1983

Microcirculation in hypertrophic burn scars.

Using the technique of capillary microscopy the microcirculation of post burn hypertrophic scars and grafts, at varying stages of maturity, have been documented. Sympathetic innervation of larger vessels beneath and within the scarred tissues could be found only in fully-matured scars, suggesting a link between the processes of scar reinnervation and maturation.

Adrenergic Fibers↗
PubMed1983

Management of the frostbitten hand.

Twenty cases of moderate and severe frostbite of the hands were analysed to establish trends in surgical treatment. Excision of large blisters and early mobilization in flamazine bags were found to be beneficial. In those patients whose initial skin changes did not extend to the base of the fingers only minor amputations were necessary. The small amounts of necrotic tissue did not interfere with hand movement and operation was therefore delayed until six or seven weeks, so that maximal digital length could be preserved. In contrast, those patients whose initial skin changes involved the whole length of the fingers or extended on to the hands, more proximal amputations were necessary and these amputations were performed at three to four weeks in order to remove the larger amounts of necrotic tissue and facilitate early mobilisation.

Adolescent↗
PubMed1982

Normal lip function in adults.

A superficial review of the literature revealed numerous types of surgical corrections for lip defects, but an in-depth search turned up little information on lip dimensions and functions. In the absence of a range of normal lip values, assessment of postoperative results is limited to the subjective impression of surgeon and patient. Using simple measuring techniques, some of the surgically important aspects of lip anatomy and function have been recorded, analyzed statistically, and presented as a range of normal values to facilitate objective comparison with abnormal and postoperative lip states.

Adult↗
PubMed1981

Hypospadias revisited.

A careful histological study of chordee tissue obtained in 30 consecutive cases of hypospadias has shown the presence of a considerable amount of smooth muscle. Preputial skin contains some elastic tissue. This feature may well provide significant advantages in the use of tubed preputial skin for urethral repair.

Humans↗
PubMed1980

The evolution of multiple mating behavior by honey bee queens (Apis mellifera L.).

A model is presented showing that natural selection operating at the individual level can adequately explain the evolution of multiple mating behavior by honey bee queens. Group selection need not be invoked. The fitness of a given female genotype is a function of the number of sex alleles in the population, the number of matings by an individual female and the specific parameters that determine the relationship of brood viability to individual fitness. Even though the exact relationship is not known, it is almost certainly not linear. A nonlinear relationship between worker brood viability and fitness and a significant genetic load associated with the sex-determination system in honey bees are the essential components of this model.

Animals↗